About: Concordancia entre dos pruebas de detección rápida para la detección de anticuerpos contra el SARS-CoV-2

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About: Concordancia entre dos pruebas de detección rápida para la detección de anticuerpos contra el SARS-CoV-2 Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Concordancia entre dos pruebas de detección rápida para la detección de anticuerpos contra el SARS-CoV-2
Creator	García, Marta De La Iglesia, Jaime Fernández Vázquez, Pedro Fernández, Pedro Fernández-Villa, Tania Fregeneda, Juan Gómez, Manuel José, Sábada Llaneza García, Marta Majo García, Raúl Majo, Raúl Manuel Gómez, ; Marcos, Alicia Mendez Da Cuña, Patricia Sanz, López Silvia López Sanz, ; Silvia, García Sábada, Alicia
Source	Elsevier; Medline; PMC
abstract	Abstract Objective: To assess the agreement between two rapid detection tests (RDT) for antibodies against SARS-CoV-2 infection. Materials and methods: This was a cross-sectional study that used a random sample of non-hospitalized patients from the primary care management division of the Healthcare Area of Leon (58 RT-PCR-positive cases and 52 RT-PCR-negative cases). Information regarding symptoms was collected and all patients were simultaneously tested using two RDTs (Combined - cRDT and Differentiated - dRDT). The results of both tests were evaluated using the chi-square test and, for degree of agreement, the kappa coefficient. Results: About 52% of the participants were women (mean age: 48.2 ± 11.0 years). A total of 58.2% were positive for d-RDT and 41.2% were positive for c-RDT. In the subjects who were RT-PCR-positive, d-RDT was positive in 72.4% and c-RDT in 55.2%; in those who were RT-PCR-negative, the percentages were 42.3% and 26.9%, respectively. The kappa coefficient observed between the two RDTs was 0.644, and was higher in patients without a fever or anosmia (0.725) and lower in those with a fever or anosmia (0.524). Conclusions: There is good agreement between the tests used in this study. Given the sensitivity observed, they can be very useful as a complement to RT-PCR. Resumen Objetivo: Evaluar la concordancia entre dos pruebas de detección rápida (PDR) de anticuerpos en la infección por SARS-CoV-2. Materiales y métodos: Estudio transversal. Se utilizó una muestra aleatoria de pacientes no hospitalizados de la Gerencia de Atención Primaria del Área de Salud de León (58 con RT-PCR positiva y 52 con RT-PCR negativa). Se recogió información sobre síntomas y a todos se les realizó simultáneamente dos PDR (Combinada: PRD-C y Diferenciada: PRD-D). Los resultados de ambas pruebas fueron evaluados mediante chi-cuadrado y el grado de concordancia con el índice Kappa. Resultados: Un 52% de los participantes fueron mujeres (edad media: 48,2 ± 11,0 años). El 58,2% fue positivo a la PDR-D y 41,2% a la PDR-C. En los sujetos RT-PCR + la PDR-D fue positiva en el 72,4% y la PDR-C en el 55,2%; en el caso de los RT-PCR – en el 42,3% y 26,9% respectivamente. El índice Kappa observado entre las dos PDR fue del 0,644, siendo mayor en pacientes sin fiebre ni anosmia (0,725) y menor en aquellos con fiebre o anosmia (0,524). Conclusiones: Existe una buena concordancia entre los test utilizados en este estudio. Dada la sensibilidad obtenida, pueden ser de gran utilidad como complemento a las RT-PCR.
has issue date	2020-06-17(xsd:dateTime)
bibo:doi	10.1016/j.semerg.2020.06.009
bibo:pmid	32675000
has license	els-covid
sha1sum (hex)	32adb9c1bb517666452c0730e1e3bc05a1e8cbe3
schema:url	https://doi.org/10.1016/j.semerg.2020.06.009
resource representing a document's title	Concordancia entre dos pruebas de detección rápida para la detección de anticuerpos contra el SARS-CoV-2
has PubMed Central identifier	PMC7298458
has PubMed identifier	32675000
schema:publication	Semergen
resource representing a document's body	covid:32adb9c1bb517666452c0730e1e3bc05a1e8cbe3#body_text
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