About: On the origin and continuing evolution of SARS-CoV-2

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	On the origin and continuing evolution of SARS-CoV-2
Creator	Zhang, Hong Qian, Zhaohui Cui, Jie Li, Xiang Song, Yuhe Duan, Yuange Lu, Jian Tang, Xiaolu Wang, Yirong Wu, Changcheng Wu, Xinkai Yao, Xinmin
Source	PMC
abstract	The SARS-CoV-2 epidemic started in late December 2019 in Wuhan, China, and has since impacted a large portion of China and raised major global concern. Herein, we investigated the extent of molecular divergence between SARS-CoV-2 and other related coronaviruses. Although we found only 4% variability in genomic nucleotides between SARS-CoV-2 and a bat SARS-related coronavirus (SARSr-CoV; RaTG13), the difference at neutral sites was 17%, suggesting the divergence between the two viruses is much larger than previously estimated. Our results suggest that the development of new variations in functional sites in the receptor-binding domain (RBD) of the spike seen in SARS-CoV-2 and viruses from pangolin SARSr-CoVs are likely caused by mutations and natural selection besides recombination. Population genetic analyses of 103 SARS-CoV-2 genomes indicated that these viruses evolved into two major types (designated L and S), that are well defined by two different SNPs that show nearly complete linkage across the viral strains sequenced to date. Although the L type (∼70%) is more prevalent than the S type (∼30%), the S type was found to be the ancestral version. Whereas the L type was more prevalent in the early stages of the outbreak in Wuhan, the frequency of the L type decreased after early January 2020. Human intervention may have placed more severe selective pressure on the L type, which might be more aggressive and spread more quickly. On the other hand, the S type, which is evolutionarily older and less aggressive, might have increased in relative frequency due to relatively weaker selective pressure. These findings strongly support an urgent need for further immediate, comprehensive studies that combine genomic data, epidemiological data, and chart records of the clinical symptoms of patients with coronavirus disease 2019 (COVID-19).
has issue date	2020-03-03(xsd:dateTime)
bibo:doi	10.1093/nsr/nwaa036
has license	cc-by
sha1sum (hex)	32758c2c2d6d9a18702e6198c3aedd80e2788d78
schema:url	https://doi.org/10.1093/nsr/nwaa036
resource representing a document's title	On the origin and continuing evolution of SARS-CoV-2
has PubMed Central identifier	PMC7107875
schema:publication	Natl Sci Rev
resource representing a document's body	covid:32758c2c2d6d9a18702e6198c3aedd80e2788d78#body_text
is schema:about of	named entity 'SARS-COV-2' named entity 'ORIGIN' named entity 'SARS-CoV-2' named entity 'EVOLUTION' named entity 'INVESTIGATED' named entity 'CORONAVIRUSES' named entity 'DIVERGENCE' named entity 'MAJOR' named entity 'STARTED' named entity 'IMPACTED' named entity 'RAISED' named entity 'PORTION' named entity '2019' named entity 'RELATED' named entity 'LARGE' named entity 'MOLECULAR' named entity 'CHINA' named entity 'EPIDEMIC' named entity 'CONCERN' named entity 'CONTINUING' named entity 'DECEMBER' named entity 'EXTENT OF' named entity 'WUHAN' named entity 'LATE' named entity 'SARS-COV-2' named entity 'GLOBAL' covid:arg/32758c2c2d6d9a18702e6198c3aedd80e2788d78 named entity 'extent' named entity 'China' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'protein sequence' named entity 'GISAID' named entity 'alleles' named entity 'ORFs' named entity 'alleles' named entity 'genome' named entity 'SARS-CoV' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'nucleotides' named entity 'viruses' named entity 'SARS-CoV-2' named entity 'concatenated coding' named entity 'SARS-CoV-2' named entity 'codon' named entity 'codons' named entity 'molecular mechanism' named entity 'Coronaviruses' named entity 'structural analysis' named entity 'nucleotides' named entity 'SARS-CoV' named entity 'genome sequences' named entity 'SARS-CoV-2 virus' named entity 'chimpanzees' named entity 'macaques' named entity 'SARS-CoV-2' named entity 'Guangxi' named entity 'DNA sequencing' named entity 'reference genome' named entity 'metagenomic sequencing' named entity 'follow-up' named entity 'SNPs' named entity 'epidemiological' named entity 'infection' named entity 'SARS-CoV-2' named entity 'orthologous sequences' named entity 'SARS-CoV-2' named entity 'sequenced genomes' named entity 'phylogenetic tree' named entity 'coronavirus disease 2019'

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