About: Glycyrrhizin improves p75NTR-associated sciatic nerve regeneration in a BALB/c mouse model

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About: Glycyrrhizin improves p75NTR-associated sciatic nerve regeneration in a BALB/c mouse model Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Glycyrrhizin improves p75NTR-associated sciatic nerve regeneration in a BALB/c mouse model
Creator	Jia, Yu-Xi Jiang, Ri-Hua Li, Jin-Ran Mao, Cui-Ying Yin, Wei-Tian
Source	PMC
abstract	Glycyrrhizin has a role in immune regulation in the central nervous system, but its impact on sciatic nerve injury had not previously been reported. In this study, a BALB/c mouse model of sciatic nerve injury was used to explore the role of glycyrrhizin in sciatic nerve repair and its underlying mechanism. Glycyrrhizin with intragastric gavage of 10 and 20 mg/kg weight per day (mid- and high-dose, respectively) inhibited p75 neurotrophin receptor (p75NTR) expression at the protein and mRNA levels versus the 5 mg/kg (low-dose) group and control (0.9% NaCl solution) at one, two, four and eight weeks following sciatic nerve injury, and simultaneously improved the action potential amplitude and motor nerve conductive velocity. Combined Marsland, Glees and Erikson’s silver stain and Luxol fast blue staining results indicated that high- and mid-dose glycyrrhizin promoted improved sciatic nerve myelination compared with the low-dose or control groups eight weeks after injury. Immunofluorescence staining demonstrated that glycyrrhizin had an inhibitory effect to a certain degree on local hypertrophic scar and inflammatory responses in the mouse model. In conclusion, glycyrrhizin can promote sciatic nerve regeneration and functional repair, in which doses of 10 and 20 mg/kg per day are more effective than lower doses, and such regeneration is associated with the downregulation of p75NTR.
has issue date	2014-02-14(xsd:dateTime)
bibo:doi	10.3892/etm.2014.1546
bibo:pmid	24940400
has license	cc-by
sha1sum (hex)	3207d738e32216ee810dcb38fdbdf73d47eafaca
schema:url	https://doi.org/10.3892/etm.2014.1546
resource representing a document's title	Glycyrrhizin improves p75NTR-associated sciatic nerve regeneration in a BALB/c mouse model
has PubMed Central identifier	PMC3991491
has PubMed identifier	24940400
schema:publication	Exp Ther Med
resource representing a document's body	covid:3207d738e32216ee810dcb38fdbdf73d47eafaca#body_text
is schema:about of	named entity 'sciatic nerve injury' named entity 'explore' named entity 'glycyrrhizin' named entity 'regeneration' named entity 'weeks' named entity 'levels' named entity 'day' named entity 'myelination' named entity 'degree' named entity 'Glycyrrhizin' named entity 'LUXOL FAST BLUE' named entity 'FUNCTIONAL' named entity 'INFLAMMATORY RESPONSES' named entity 'MEDICINE' named entity 'GLYCYRRHIZIN' named entity 'EXPERIMENTAL' named entity 'GAVAGE' named entity 'VELOCITY' named entity 'COMBINED' named entity 'EXPRESSION' named entity 'IMMUNE' named entity 'MOUSE MODEL' named entity 'USED' named entity 'SCIATIC NERVE INJURY' named entity 'MOUSE MODEL' named entity 'RESULTS' named entity 'CONTROL' named entity 'NERVE REPAIR' named entity 'MECHANISM' named entity 'CONCLUSION' named entity 'WEIGHT' named entity 'GLYCYRRHIZIN' named entity 'INHIBITED' named entity 'EFFECTIVE' named entity '27S' named entity 'ASSOCIATED' named entity 'BALB' named entity 'P75NTR' named entity 'IMPROVES' named entity 'SCIATIC NERVE' named entity 'MRNA' named entity 'PER DAY' named entity 'GROUP' named entity 'HIGH-DOSE' named entity 'ITS' named entity 'ACTION POTENTIAL' named entity 'REPORTED' named entity 'UNDERLYING' named entity 'BUT' named entity 'MODEL OF' named entity 'IMPROVED' named entity 'INHIBITORY EFFECT' named entity 'NACL' named entity 'PREVIOUSLY' named entity 'CERTAIN' named entity 'P75NTR' named entity 'PROTEIN ' named entity 'MG%' named entity 'MOTOR NERVE' named entity 'P75 NEUROTROPHIN RECEPTOR' named entity 'INDICATED' named entity 'REGENERATION' named entity 'HYPERTROPHIC SCAR' named entity 'COMPARED' named entity 'CONTROL GROUPS' named entity 'SCIATIC NERVE' named entity 'DEGREE' named entity 'REGULATION' named entity 'INTRAGASTRIC' named entity 'AMPLITUDE' named entity 'ASSOCIATED WITH' named entity 'STAINING' named entity 'SOLUTION' named entity 'NERVE REGENERATION' named entity 'DOSE' named entity 'DOSES' named entity 'IMMUNOFLUORESCENCE STAINING'

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