About: Clinical characteristics and outcome of Penicillium marneffei infection among HIV-infected patients in northern Vietnam

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About: Clinical characteristics and outcome of Penicillium marneffei infection among HIV-infected patients in northern Vietnam Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical characteristics and outcome of Penicillium marneffei infection among HIV-infected patients in northern Vietnam
Creator	Horby, Peter Taylor, Walter Nguyen, Kinh Nguyen, Thi Nguyen, Trung Le, Thuy Larsson, Mattias Ha, Lien Dao, Trinh Fl, Heiman Ha, Minh
Source	PMC
abstract	OBJECTIVE: This study reports the clinical characteristics and outcome of HIV-associated Penicilliummarneffei infection in northern Vietnam. METHODS: We conducted a retrospective chart review of all patients with laboratory confirmed Penicilliummarneffei infection admitted to the National Hospital for Tropical Diseases in Hanoi, Vietnam, between July 2006 and September 2009. RESULTS: 127 patients with P. marneffei infection were identified. All were HIV-infected; median CD4+ T-cell count was 24 cells/μl (IQR:12-48); 76% were men. Common clinical features were fever (92.9%), skin lesions (82.6%), hepatomegaly (61.4%), lymphadenopathy (40.2%), weight loss (59.1%) and cough (49.6%). Concurrent opportunistic infections were present in 22.0%; half of those had tuberculosis. Initial treatment regimens were: itraconazole or ketoconazole capsule (77.2%), amphotericin B (20.5%), and fluconazole (1.6%). In-hospital mortality was 12.6% and showed no significant difference in patients treated with itraconazole (or ketoconazole) and amphotericin B (p = 0.43). Dyspnea, ascites, and increased LDH level were independent predictors of mortality. No seasonality was observed. CONCLUSION: The clinical features, treatments and outcomes of HIV-associated P. marneffei infection in northern Vietnam are similar to those reported in other endemic regions. Dyspnea was an important predictor of mortality. More patients were treated with itraconazole than amphotericin B and no significant difference in treatment outcome was observed. It would be of clinical value to compare the efficacy of oral itraconazole and amphotericin B in a clinical trial.
has issue date	2012-08-16(xsd:dateTime)
bibo:doi	10.1186/1742-6405-9-24
bibo:pmid	22897817
has license	cc-by
sha1sum (hex)	31ee8253e60f86c73a61998eafc1f555a4d14e0b
schema:url	https://doi.org/10.1186/1742-6405-9-24
resource representing a document's title	Clinical characteristics and outcome of Penicillium marneffei infection among HIV-infected patients in northern Vietnam
has PubMed Central identifier	PMC3439243
has PubMed identifier	22897817
schema:publication	AIDS Res Ther
resource representing a document's body	covid:31ee8253e60f86c73a61998eafc1f555a4d14e0b#body_text
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