About: Unique and Conserved Features of Genome and Proteome of SARS-coronavirus, an Early Split-off From the Coronavirus Group 2 Lineage

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About: Unique and Conserved Features of Genome and Proteome of SARS-coronavirus, an Early Split-off From the Coronavirus Group 2 Lineage Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Unique and Conserved Features of Genome and Proteome of SARS-coronavirus, an Early Split-off From the Coronavirus Group 2 Lineage
Creator	Thiel, Volker Guan, Yi Ziebuhr, John Poon, Leo Spaan, Willy Gorbalenya, Alexander Snijder, Eric Rozanov, Mikhail Bredenbeek, Peter Dobbe, Jessika
Source	Elsevier; Medline; PMC
abstract	Abstract The genome organization and expression strategy of the newly identified severe acute respiratory syndrome coronavirus (SARS-CoV) were predicted using recently published genome sequences. Fourteen putative open reading frames were identified, 12 of which were predicted to be expressed from a nested set of eight subgenomic mRNAs. The synthesis of these mRNAs in SARS-CoV-infected cells was confirmed experimentally. The 4382- and 7073 amino acid residue SARS-CoV replicase polyproteins are predicted to be cleaved into 16 subunits by two viral proteinases (bringing the total number of SARS-CoV proteins to 28). A phylogenetic analysis of the replicase gene, using a distantly related torovirus as an outgroup, demonstrated that, despite a number of unique features, SARS-CoV is most closely related to group 2 coronaviruses. Distant homologs of cellular RNA processing enzymes were identified in group 2 coronaviruses, with four of them being conserved in SARS-CoV. These newly recognized viral enzymes place the mechanism of coronavirus RNA synthesis in a completely new perspective. Furthermore, together with previously described viral enzymes, they will be important targets for the design of antiviral strategies aimed at controlling the further spread of SARS-CoV.
has issue date	2003-08-29(xsd:dateTime)
bibo:doi	10.1016/s0022-2836(03)00865-9
bibo:pmid	12927536
has license	els-covid
sha1sum (hex)	31c0669af6f86903dc621787dbe547167c0980da
schema:url	https://doi.org/10.1016/s0022-2836%2803%2900865-9
resource representing a document's title	Unique and Conserved Features of Genome and Proteome of SARS-coronavirus, an Early Split-off From the Coronavirus Group 2 Lineage
has PubMed Central identifier	PMC7159028
has PubMed identifier	12927536
schema:publication	Journal of Molecular Biology
resource representing a document's body	covid:31c0669af6f86903dc621787dbe547167c0980da#body_text
is schema:about of	named entity 'viral' named entity 'gene' named entity 'SARS-CoV' named entity 'unique' named entity 'subunits' named entity 'replicase' named entity 'GENOME' named entity 'CORONAVIRUS GROUP 2' named entity 'PROTEINS' named entity 'DESIGN' named entity 'VIRAL' named entity 'PREDICTED' named entity 'VIRAL ENZYMES' named entity 'RNA SYNTHESIS' named entity 'NUMBER OF' named entity 'PUBLISHED' named entity 'SYNTHESIS' named entity 'OPEN READING FRAMES' named entity 'TOTAL NUMBER' named entity 'GENOME ORGANIZATION' named entity 'IMPORTANT' named entity 'INFECTED' named entity 'EARLY' named entity 'CONTROLLING' named entity 'CONSERVED' named entity 'CONFIRMED' named entity 'RELATED' named entity 'ENZYMES' named entity 'THESE' named entity 'FEATURES' named entity 'UNIQUE' named entity 'CORONAVIRUS' named entity 'LINEAGE' named entity 'SPLIT' named entity 'CONSERVED' named entity 'PROTEOME' named entity 'STRATEGIES' named entity 'GROUP 2' named entity 'BEING' named entity 'AMINO ACID RESIDUE' named entity 'COMPLETELY' named entity 'REPLICASE' named entity 'UNIQUE' named entity 'PREVIOUSLY' named entity 'SET' named entity 'NEWLY' named entity 'PROTEINASES' named entity 'PERSPECTIVE' named entity 'TOROVIRUS' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS' named entity 'SARS' named entity 'DISTANT' named entity 'GENE' named entity 'NESTED' named entity 'USING' named entity 'DESCRIBED' named entity 'TARGETS' named entity 'RECENTLY' named entity 'FOURTEEN' named entity 'SPREAD' named entity 'RNA PROCESSING' named entity 'MRNAS' named entity 'CELLULAR' named entity 'STRATEGY' named entity 'TO BE CLEAVED' named entity 'SARS-COV' named entity 'IDENTIFIED' named entity 'SEQUENCES' named entity 'DISTANTLY' named entity 'FEATURES' named entity 'ANTIVIRAL' named entity 'MECHANISM'

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