About: MERS-CoV infection is associated with downregulation of genes encoding Th1 and Th2 cytokines/chemokines and elevated inflammatory innate immune response in the lower respiratory tract

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: MERS-CoV infection is associated with downregulation of genes encoding Th1 and Th2 cytokines/chemokines and elevated inflammatory innate immune response in the lower respiratory tract Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	MERS-CoV infection is associated with downregulation of genes encoding Th1 and Th2 cytokines/chemokines and elevated inflammatory innate immune response in the lower respiratory tract
Creator	Assiri, Abdullah Al-Eisa, Kholoud Alosaimi, Bandar Khojah, Taghreed Naeem, Asif Alamri, Aref Aldosari, Kamel Alsharef, Ali Hamed, Maaweya Alqahtani, Saeed Enani, Mushira
Source	Elsevier; Medline; PMC
abstract	Abstract MERS-CoV, a highly pathogenic virus in humans, is associated with high morbidity and case fatality. Inflammatory responses have a significant impact on MERS-CoV pathogenesis and disease outcome. However, CD4+ T-cell induced immune responses during acute MERS-CoV infection are barely detectable, with potent inhibition of effector T cells and downregulation of antigen presentation. The local pulmonary immune response, particularly the Th1 and Th2-related immune response during acute severe MERS-CoV infection is not fully understood. In this study, we offer the first insights into the pulmonary gene expression profile of Th1 and Th2-related cytokines/chemokines (Th1 & Th2 responses) during acute MERS-CoV infection using RT2 Profiler PCR Arrays. We also quantified the expression level of primary inflammatory cytokines/chemokines. Our results showed a downregulation of Th2, inadequate (partial) Th1 immune response and high expression levels of inflammatory cytokines IL-1α and IL-1β and the neutrophil chemoattractant chemokine IL-8 (CXCL8) in the lower respiratory tract of MERS-CoV infected patients. Moreover, we identified a high viral load in all included patients. We also observed a correlation between inflammatory cytokines, Th1, and Th2 downregulation and the case fatality rate. Th1 and Th2 response downregulation, high expression of inflammatory cytokines, and high viral load may contribute to lung inflammation, severe infection, the evolution of pneumonia and ARDS, and a higher case fatality rate. Further study of the molecular mechanisms underlying the Th1 and Th2 regulatory pathways will be vital for active vaccine development and the identification of novel therapeutic strategies.
has issue date	2020-02-29(xsd:dateTime)
bibo:doi	10.1016/j.cyto.2019.154895
bibo:pmid	31706200
has license	els-covid
sha1sum (hex)	319663b2ac3cd9beb28724b6a3f4e2e6b0c2c59a
schema:url	https://doi.org/10.1016/j.cyto.2019.154895
resource representing a document's title	MERS-CoV infection is associated with downregulation of genes encoding Th1 and Th2 cytokines/chemokines and elevated inflammatory innate immune response in the lower respiratory tract
has PubMed Central identifier	PMC7128721
has PubMed identifier	31706200
schema:publication	Cytokine
resource representing a document's body	covid:319663b2ac3cd9beb28724b6a3f4e2e6b0c2c59a#body_text
is schema:about of	named entity 'highly' named entity 'high' named entity 'case fatality rate' named entity 'response' named entity 'high' named entity 'development' named entity 'pathogenesis' named entity 'molecular mechanisms' named entity 'chemokines' named entity 'downregulation' named entity 'local' named entity 'innate immune response' named entity 'DOWNREGULATION' named entity 'ELEVATED' named entity 'INFECTION' named entity 'TH2' named entity 'INCLUDED' named entity 'INFLAMMATORY RESPONSES' named entity 'CASE FATALITY RATE' named entity 'UNDERLYING' named entity 'SEVERE' named entity 'USING' named entity 'MOLECULAR' named entity 'EVOLUTION' named entity 'VIRAL LOAD' named entity 'DETECTABLE' named entity 'THERAPEUTIC' named entity 'HAVE' named entity 'PNEUMONIA' named entity 'IMMUNE RESPONSE' named entity 'ARDS' named entity 'DISEASE OUTCOME' named entity 'ACTIVE' named entity 'CASE' named entity 'ASSOCIATED WITH' named entity 'TH2 RESPONSE' named entity 'EFFECTOR T CELLS' named entity 'PRIMARY' named entity 'IL-1' named entity 'PATHOGENIC' named entity 'STRATEGIES' named entity 'VITAL' named entity 'ACUTE' named entity 'CYTOKINES' named entity 'REGULATORY' named entity 'CONTRIBUTE ' named entity 'INDUCED' named entity 'SEVERE INFECTION' named entity 'CD4' named entity 'RESULTS' named entity 'RESPONSES' named entity 'OFFER' named entity 'VACCINE DEVELOPMENT' named entity 'OBSERVED' named entity 'IDENTIFIED' named entity 'CHEMOATTRACTANT' named entity 'UNDERSTOOD' named entity 'INADEQUATE ' named entity 'SIGNIFICANT' named entity 'VIRUS' named entity 'INHIBITION' named entity 'IMPACT' named entity 'EXPRESSION LEVEL' named entity 'ANTIGEN PRESENTATION' named entity 'INFLAMMATORY' named entity 'LOWER RESPIRATORY TRACT' named entity 'TH2' named entity 'ASSOCIATED WITH' named entity 'TH1' named entity 'HIGHLY' named entity 'PCR ARRAYS'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software