About: Human Bocavirus in Children Hospitalized for Acute Gastroenteritis: A Case-Control Study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Human Bocavirus in Children Hospitalized for Acute Gastroenteritis: A Case-Control Study
Creator	Cid, Bocavirus, Human Gastroenteritis, •
Source	PMC
abstract	Background. Human bocavirus (HBoV) was recently discovered in children with respiratory tract disease and gastroenteritis. The causative role of HBoV in human gastroenteritis remains uncertain, and, to our knowledge, no previous case-control study has studied the relationship between HBoV and gastroenteritis. Methods. We conducted a case-control study that examined stool samples from 397 children with diarrhea and from 115 asymptomatic control subjects. HBoV was detected using polymerase chain reaction. Real-time polymerase chain reaction was used to quantify the HBoV loads in case and control groups. Common enteric viruses were examined using enzyme-linked immunosorbent assays, polymerase chain reaction, and reverse-transcription polymerase chain reaction. Results. At least 1 viral agent was discovered in 60.2% of cases. HBoV was detected in 14 samples, and 9 were coinfected with either rotavirus (7 of 14 samples) or human calicivirus (2 of 14). Many (8 [57.1%] of 14) of the HBoV infections occurred during September-December 2006. Most (12 [85.7%]) of the HBoV-infected children were 7–18 months of age. The percentage of children with HBoV infection did not differ significantly between case patients and control subjects (3.5% vs. 3.5%), and the statistical analysis did not support a correlation between HBoV infection and more-severe clinical symptoms. The viral load differences between the 2 groups were not statistically significant (P = .09, by log-normal Student's t test). In addition, the VP1/VP2 partial gene of HBoV from case patients and control subjects showed minimal sequence variation. Conclusions. A single genetic lineage of HBoV was revealed in persons in China. Despite its high prevalence in stool samples, our study does not support a causative role of HBoV in gastroenteritis.
has issue date	2008-07-15(xsd:dateTime)
bibo:doi	10.1086/589244
bibo:pmid	18532891
has license	no-cc
sha1sum (hex)	3186f38a1e7c1edd1b6a1d17fef30a79b9124801
schema:url	https://doi.org/10.1086/589244
resource representing a document's title	Human Bocavirus in Children Hospitalized for Acute Gastroenteritis: A Case-Control Study
has PubMed Central identifier	PMC7107984
has PubMed identifier	18532891
schema:publication	Clin Infect Dis
resource representing a document's body	covid:3186f38a1e7c1edd1b6a1d17fef30a79b9124801#body_text
is schema:about of	named entity 'Human bocavirus' named entity 'respiratory tract' named entity 'CASE-CONTROL STUDY' named entity 'CHILDREN HOSPITALIZED' named entity 'ACUTE GASTROENTERITIS' named entity 'HUMAN BOCAVIRUS' named entity 'CASE-CONTROL STUDY' named entity 'HUMAN BOCAVIRUS' named entity 'CHILDREN' named entity 'HUMAN' named entity 'RECENTLY' named entity 'RESPIRATORY TRACT DISEASE' named entity 'ROLE' named entity 'PREVIOUS' named entity 'GASTROENTERITIS' named entity 'UNCERTAIN' named entity 'OUR' named entity 'BACKGROUND' named entity 'RELATIONSHIP' named entity 'KNOWLEDGE' covid:arg/3186f38a1e7c1edd1b6a1d17fef30a79b9124801 named entity 'discovered' named entity 'gastroenteritis' named entity 'gastroenteritis' named entity 'gastroenteritis' named entity 'case-control study' named entity 'respiratory tract disease' named entity 'Acute Gastroenteritis' named entity 'Case-Control Study' named entity 'Virological' named entity 'HBoV' named entity 'log-normal' named entity 'virus' named entity 'fever' named entity 'HBoV' named entity 'Gastroenteritis' named entity 'enteric viruses' named entity 'Qiagen' named entity 'DNA sequence' named entity 'gastroenteritis' named entity 'pathogen' named entity 'gastroenteritis' named entity 'phosphate-buffered saline' named entity 'gastroenteritis' named entity 'Student's t test' named entity 'rotavirus' named entity 'gastroenteritis' named entity 'HBoV' named entity 'base pair' named entity 'HBoV' named entity '1.2' named entity 'etiology' named entity 'HBoV' named entity 'genotype' named entity 'parvoviridae' named entity 'vomiting' named entity 'HBoV' named entity 'gastroenteritis' named entity 'HBoV' named entity 'gastroenteritis' named entity 'gastroenteritis' named entity 'HBoV' named entity 'gastroenteritis' named entity 'immune response' named entity 'HBoV' named entity 'PCR' named entity 'noroviruses' named entity 'control group' named entity 'enteric disease' named entity 'enteric viruses' named entity 'gastroenteritis' named entity 'Lanzhou University' named entity 'gene' named entity 'diarrhea' named entity 'gastroenteritis' named entity 'HBoV' named entity 'clinical symptoms' named entity 'HBoV' named entity 'HBoV'

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