About: A public antibody lineage that potently inhibits malaria infection by dual binding to the circumsporozoite protein

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About: A public antibody lineage that potently inhibits malaria infection by dual binding to the circumsporozoite protein Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A public antibody lineage that potently inhibits malaria infection by dual binding to the circumsporozoite protein
Creator	Lanzavecchia, Antonio Sallusto, Federica Foglierini, Mathilde Varani, Luca Corradin, Giampietro Barbieri, Sonia Piccoli, Luca Tan, Joshua Abdulla, Salim Marcandalli, Jessica Perez, Laurent Daubenberger, Claudia Jongo, Said Zenklusen, Isabelle Wilson, Ian Fregni, Chiara Hoffman, Stephen Kappe, Stefan Oyen, David Sack, Brandon Sim, Kim
Source	Medline; PMC
abstract	Immunization with attenuated Plasmodium falciparum sporozoites (PfSPZ) has been shown to be protective, but the features of the antibody response induced by this treatment remain unclear. To investigate this response at high resolution, we isolated IgM and IgG monoclonal antibodies from Tanzanian volunteers who were immunized by repeated injection of irradiated PfSPZ and who were found to be protected from controlled human malaria infection (CHMI) with infectious homologous PfSPZ. All IgG monoclonals isolated bound to P. falciparum circumsporozoite protein (PfCSP) and recognized distinct epitopes in the N-terminus, NANP repeat region, and C-terminus. Strikingly, the most effective antibodies, as assessed in a humanized mouse model, bound not only to the repeat region, but also to a minimal peptide at the PfCSP N-terminal junction that is not in the RTS,S vaccine. These dual-specific antibodies were isolated from different donors and used VH3-30 or VH3-33 alleles carrying tryptophan or arginine at position 52. Using structural and mutational data, we describe the elements required for germline recognition and affinity maturation. Our study provides potent neutralizing antibodies and relevant information for lineage-targeted vaccine design and immunization strategies.
has issue date	2018-03-19(xsd:dateTime)
bibo:doi	10.1038/nm.4513
bibo:pmid	29554084
has license	no-cc
sha1sum (hex)	3184616f8c024012a6d2d460222d2fb5e56fd98a
schema:url	https://doi.org/10.1038/nm.4513
resource representing a document's title	A public antibody lineage that potently inhibits malaria infection by dual binding to the circumsporozoite protein
has PubMed Central identifier	PMC5893353
has PubMed identifier	29554084
schema:publication	Nat Med
resource representing a document's body	covid:3184616f8c024012a6d2d460222d2fb5e56fd98a#body_text
is schema:about of	named entity 'LINEAGE' named entity 'TREATMENT' named entity 'DOCUMENTS' named entity 'INDUCED' named entity 'DUAL' named entity 'ATTENUATED' named entity 'DATA' named entity 'COPY' named entity 'BUT' named entity 'UNCLEAR' named entity 'CONTENT' named entity 'MALARIA' named entity 'BINDING' named entity 'INFECTION' named entity 'FEATURES' named entity 'ANTIBODY' named entity 'PURPOSES' named entity 'MAY VIEW' named entity 'SUBJECT' named entity 'RESEARCH' named entity 'PUBLIC' named entity 'ACADEMIC' named entity 'ANTIBODY RESPONSE' named entity 'SPOROZOITES' named entity 'IMMUNIZATION' named entity 'USE' named entity 'PRINT' named entity 'USERS' named entity 'CONDITIONS' named entity 'CIRCUMSPOROZOITE PROTEIN' named entity 'PLASMODIUM FALCIPARUM' named entity 'TEXT' named entity 'features' named entity 'response' named entity 'attenuated' named entity 'sporozoites' named entity 'malaria infection' named entity 'IgG' named entity 'motif' named entity 'NANP' named entity 'IgM' named entity 'peptides' named entity 'vaccination' named entity 'virus' named entity 'amide backbone' named entity 'gene' named entity 'fluorescence' named entity 'peptide' named entity 'high affinity' named entity 'model organism' named entity 'SWISS-MODEL' named entity 'antibody' named entity 'peptide' named entity 'light chains' named entity 'IgD' named entity 'ENVIGO' named entity 'Fab' named entity 'Ac-1' named entity 'antibodies' named entity 'vaccine design' named entity 'antibody response'

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