About: Lower respiratory tract myeloid cells harbor SARS-CoV-2 and display an inflammatory phenotype

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About: Lower respiratory tract myeloid cells harbor SARS-CoV-2 and display an inflammatory phenotype Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Lower respiratory tract myeloid cells harbor SARS-CoV-2 and display an inflammatory phenotype
Creator	Morris, Alison Watkins, Simon Bjorkman, Pamela Watson, Alan Kitsios, Georgios Bain, William Lee, Janet Ladinsky, Mark Mcverry, Bryan Methe, Barbara Peñaloza, Hernán Ross, Mark St Croix, Claudette Stolz, Donna Sullivan, Mara Van Der Geest, Rick
Source	MedRxiv; Medline
abstract	SARS-CoV-2 pneumonia may induce an aberrant immune response with brisk recruitment of myeloid cells into the lower respiratory tract, which may contribute to morbidity and mortality. We describe endotracheal aspirate samples from seven patients with SARS-CoV-2 pneumonia requiring mechanical ventilation. We note SARS-CoV-2 virions within lower respiratory tract myeloid cells shown by electron tomography, immunofluorescence confocal imaging, and immuno-electron microscopy. Endotracheal aspirates are primarily composed of mononuclear and polymorphonuclear leukocytes. These myeloid cells that harbor virus are frequently positive for CD14 and/or CD16 and most display an inflammatory phenotype marked by expression of IL-6 and tissue factor mRNA transcript and protein expression.
has issue date	2020-08-14(xsd:dateTime)
bibo:doi	10.1101/2020.08.11.20171967
bibo:pmid	32817968
has license	medrxiv
sha1sum (hex)	316a1b031f1e9e5b4bad5fa45616b165debf83da
schema:url	https://doi.org/10.1101/2020.08.11.20171967
resource representing a document's title	Lower respiratory tract myeloid cells harbor SARS-CoV-2 and display an inflammatory phenotype
has PubMed identifier	32817968
schema:publication	medRxiv : the preprint server for health sciences
resource representing a document's body	covid:316a1b031f1e9e5b4bad5fa45616b165debf83da#body_text
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