About: Autophagy enhances the replication of Peste des petits ruminants virus and inhibits caspase-dependent apoptosis in vitro

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Autophagy enhances the replication of Peste des petits ruminants virus and inhibits caspase-dependent apoptosis in vitro Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Autophagy enhances the replication of Peste des petits ruminants virus and inhibits caspase-dependent apoptosis in vitro
Creator	Yang, Bo Chen, Shuying Jia, Peilong Qi, Xuefeng Wang, Jingyu Wang, Ting Xue, Qinghong Wang, Xueping Xue, Tianxia
Source	PMC
abstract	Peste des petits ruminants (PPR) is an acute and highly contagious disease in small ruminants that causes significant economic losses in developing countries. An increasing number of studies have demonstrated that both autophagy and apoptosis are important cellular mechanisms for maintaining homeostasis, and they participate in the host response to pathogens. However, the crosstalk between apoptosis and autophagy in host cells during PPRV infection has not been clarified. In this study, autophagy was induced upon virus infection in caprine endometrial epithelial cells (EECs), as determined by the appearance of double- and single-membrane autophagy-like vesicles, LC3-I/LC3-II conversion, and p62 degradation. We also found that PPRV infection triggered a complete autophagic response, most likely mediated by the non-structural protein C and nucleoprotein N. Moreover, our results suggest that autophagy not only promotes the replication of PPRV in EECs but also provides a potential mechanism for inhibiting PPRV-induced apoptosis. Inhibiting autophagosome formation by wortmannin and knocking down the essential autophagic proteins Beclin-1 and ATG7 induces caspase-dependent apoptosis in EECs in PPRV infection. However, inhibiting autophagosome and lysosome fusion by NH(4)Cl and chloroquine did not increase the number of apoptotic cells. Collectively, these data are the first to indicate that PPRV-induced autophagy inhibits caspase-dependent apoptosis and thus contributes to the enhancement of viral replication and maturity in host cells.
has issue date	2018-08-01(xsd:dateTime)
bibo:doi	10.1080/21505594.2018.1496776
bibo:pmid	30067475
has license	cc-by
sha1sum (hex)	3133b38c4350e52953e57b9fc8f0290ab133cc0a
schema:url	https://doi.org/10.1080/21505594.2018.1496776
resource representing a document's title	Autophagy enhances the replication of Peste des petits ruminants virus and inhibits caspase-dependent apoptosis in vitro
has PubMed Central identifier	PMC6086290
has PubMed identifier	30067475
schema:publication	Virulence
resource representing a document's body	covid:3133b38c4350e52953e57b9fc8f0290ab133cc0a#body_text
is schema:about of	named entity 'essential' named entity 'apoptotic cells' named entity 'number' named entity 'cells' named entity 'However' named entity 'response' named entity 'host' named entity 'caprine' named entity 'virus' named entity 'CAPRINE' named entity 'AUTOPHAGY' named entity 'ENDOMETRIAL' named entity 'NON-' named entity 'INHIBITING' named entity 'CHLOROQUINE' named entity 'INDUCED' named entity 'CASPASE-DEPENDENT APOPTOSIS' named entity 'CELLS' named entity 'infection' named entity 'EECs' named entity 'autophagosome' named entity 'data' named entity 'maturity' named entity 'autophagy' named entity 'fusion' named entity 'apoptosis' named entity 'autophagy' named entity 'host cells' named entity 'autophagy' named entity 'apoptosis' named entity 'lysosome' named entity 'autophagic response' named entity 'wortmannin' named entity 'endometrial' named entity 'apoptotic cells' named entity 'caspase-dependent apoptosis' named entity 'Beclin-1' named entity 'autophagic' named entity 'Peste des petits ruminants' named entity 'caspase-dependent apoptosis' named entity 'Peste des petits ruminants' named entity 'virus' named entity 'infection' named entity '0.01' named entity 'infection' named entity 'foetal bovine serum' named entity 'Bio-Rad' named entity 'protein' named entity 'infection' named entity 'haemagglutinin' named entity 'rapamycin' named entity 'phosphate-buffered saline' named entity 'autophagosome' named entity 'autophagic' named entity 'hpi' named entity 'qPCR' named entity 'Beijing' named entity 'nucleocapsid' named entity 'PPRV' named entity 'Caprine' named entity 'PPRV' named entity 'autophagy' named entity 'primary antibody' named entity 'LAMP1' named entity 'China' named entity 'PPRV' named entity 'autophagosome' named entity 'genus' named entity 'TUNEL' named entity 'ATG7' named entity 'flow cytometry' named entity 'autophagosome' named entity 'caspase-9'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software