About: Management of HIV-infected patients in the intensive care unit

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Management of HIV-infected patients in the intensive care unit
Creator	Tattevin, Pierre Azoulay, Élie Bouadma, Lila Barbier, François Miller, Robert Szychowiak, Piotr Galicier, Lionel Mariotte, Éric Mer, Mervin
source	PMC
abstract	The widespread use of combination antiretroviral therapies (cART) has converted the prognosis of HIV infection from a rapidly progressive and ultimately fatal disease to a chronic condition with limited impact on life expectancy. Yet, HIV-infected patients remain at high risk for critical illness due to the occurrence of severe opportunistic infections in those with advanced immunosuppression (i.e., inaugural admissions or limited access to cART), a pronounced susceptibility to bacterial sepsis and tuberculosis at every stage of HIV infection, and a rising prevalence of underlying comorbidities such as chronic obstructive pulmonary diseases, atherosclerosis or non-AIDS-defining neoplasms in cART-treated patients aging with controlled viral replication. Several patterns of intensive care have markedly evolved in this patient population over the late cART era, including a steady decline in AIDS-related admissions, an opposite trend in admissions for exacerbated comorbidities, the emergence of additional drivers of immunosuppression (e.g., anti-neoplastic chemotherapy or solid organ transplantation), the management of cART in the acute phase of critical illness, and a dramatic progress in short-term survival that mainly results from general advances in intensive care practices. Besides, there is a lack of data regarding other features of ICU and post-ICU care in these patients, especially on the impact of sociological factors on clinical presentation and prognosis, the optimal timing of cART introduction in AIDS-related admissions, determinants of end-of-life decisions, long-term survival, and functional outcomes. In this narrative review, we sought to depict the current evidence regarding the management of HIV-infected patients admitted to the intensive care unit.
has issue date	2020-02-03(xsd:dateTime)
bibo:doi	10.1007/s00134-020-05945-3
bibo:pmid	32016535
has license	no-cc
sha1sum (hex)	310b92439db3ed9ec3a094bac7782b297b99751d
schema:url	https://doi.org/10.1007/s00134-020-05945-3
resource representing a document's title	Management of HIV-infected patients in the intensive care unit
has PubMed Central identifier	PMC7095039
has PubMed identifier	32016535
schema:publication	Intensive Care Med
resource representing a document's body	covid:310b92439db3ed9ec3a094bac7782b297b99751d#body_text
is schema:about of	named entity 'tuberculosis' named entity 'presentation' named entity 'controlled' named entity 'functional' named entity 'narrative review' named entity 'LIFE' named entity 'DECLINE' named entity 'SEVERE' named entity 'ACUTE PHASE' named entity 'SHORT-TERM' named entity 'FATAL DISEASE' named entity 'CRITICAL ILLNESS' named entity 'PROGNOSIS' named entity 'PATIENTS' named entity 'NARRATIVE REVIEW' named entity '28I' named entity 'determinants' named entity 'progress' named entity 'care' named entity 'additional' named entity 'prognosis' named entity 'rapidly' named entity 'solid' named entity 'limited' named entity 'pulmonary diseases' named entity 'decline' named entity 'intensive care' named entity 'infection' named entity 'critical illness' named entity 'severe' named entity 'chronic condition' named entity 'clinical presentation' named entity 'neoplasms' named entity 'life expectancy' named entity 'chronic condition' named entity 'immunosuppression' named entity 'antiretroviral' named entity 'cART' named entity 'HIV infection' named entity 'prognosis' named entity 'cART' named entity 'intensive care' named entity 'bacterial sepsis' named entity 'viral replication' named entity 'HIV-infected patients' named entity 'integrase inhibitors' named entity 'ethambutol' named entity 'ICU' named entity 'anthracycline' named entity 'esophagitis' named entity 'MSD' named entity 'viral load' named entity 'trimethoprim' named entity 'neurologic disorders' named entity 'focal signs' named entity 'resistant strains' named entity 'cART' named entity 'acid-fast bacilli' named entity 'end-organ' named entity 'intestinal tract' named entity 'basal ganglia' named entity 'CD4 cells' named entity 'hemodynamic' named entity 'cavitation' named entity 'supportive care' named entity 'intensive care unit' named entity 'comorbid conditions' named entity 'rituximab' named entity 'HIV infection' named entity 'NHL' named entity 'glucose-6-phosphate dehydrogenase deficiency' named entity 'antacids' named entity 'acute HIV infection'

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