About: Replication-competent vesicular stomatitis virus vaccine vector protects against SARS-CoV-2-mediated pathogenesis in mice

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About: Replication-competent vesicular stomatitis virus vaccine vector protects against SARS-CoV-2-mediated pathogenesis in mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Replication-competent vesicular stomatitis virus vaccine vector protects against SARS-CoV-2-mediated pathogenesis in mice
Creator	Zhao, Haiyan Bloyet, Louis-Marie Diamond, Michael Case, James Chen, R Fox, Julie Fremont, Daved Harvey, S Ma, H Whelan, Sean Holtzman, E Holtzman, Michael Mccune, Broc Winkler, Emma Adams, M Kafai, Natasha Case, J Chen, Rita Fox, J Harvey, Ian Kafai, N Keeler, Shamus Rothlauf, Paul Rothlauf, P Shrihari, Swathi Smith, Brittany Whelan, D Adams, Lucas Ma, Meisheng Keeler, I Winkler, L Zhao, L.-M
Source	Elsevier; Medline; PMC
abstract	SUMMARY Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused millions of human infections and an effective vaccine is critical to mitigate coronavirus-induced disease 2019 (COVID-19). Previously, we developed a replication-competent vesicular stomatitis virus (VSV) expressing a modified form of the SARS-CoV-2 spike gene in place of the native glycoprotein gene (VSV-eGFP-SARS-CoV-2). Here, we show that vaccination with VSV-eGFP-SARS-CoV-2 generates neutralizing immune responses and protects mice from SARS-CoV-2. Immunization of mice with VSV-eGFP-SARS-CoV-2 elicits high antibody titers that neutralize SARS-CoV-2 and target the receptor binding domain that engages human angiotensin converting enzyme-2 (ACE2). Upon challenge with a human isolate of SARS-CoV-2, mice expressing human ACE2 and immunized with VSV-eGFP-SARS-CoV-2 show profoundly reduced viral infection and inflammation in the lung, indicating protection against pneumonia. Passive transfer of sera from VSV-eGFP-SARS-CoV-2-immunized animals also protects naïve mice from SARS-CoV-2 challenge. These data support development of VSV-eGFP-SARS-CoV-2 as an attenuated, replication-competent vaccine against SARS-CoV-2.
has issue date	2020-07-30(xsd:dateTime)
bibo:doi	10.1016/j.chom.2020.07.018
bibo:pmid	32798445
has license	els-covid
sha1sum (hex)	30fa8caead381bdbf8e5f044ebd1ad6f7d3225ba
schema:url	https://doi.org/10.1016/j.chom.2020.07.018
resource representing a document's title	Replication-competent vesicular stomatitis virus vaccine vector protects against SARS-CoV-2-mediated pathogenesis in mice
has PubMed Central identifier	PMC7391951
has PubMed identifier	32798445
schema:publication	Cell Host Microbe
resource representing a document's body	covid:30fa8caead381bdbf8e5f044ebd1ad6f7d3225ba#body_text
is schema:about of	named entity 'glycoprotein' named entity 'SARS-CoV-2' named entity 'Severe acute respiratory syndrome coronavirus 2' named entity 'immune responses' named entity 'Microbe' named entity 'pathogenesis' named entity 'mice' named entity 'mice' named entity 'doi' named entity 'doi' named entity 'Replication' named entity 'mice' named entity 'vesicular stomatitis virus' named entity 'vaccine' named entity 'SARS-CoV-2' named entity 'mice' named entity 'eGFP' named entity 'eGFP' named entity 'passive transfer' named entity 'spleen' named entity 'SARS-CoV-2' named entity 'BALB/c' named entity 'spleen' named entity 'SARS-CoV-2' named entity 'VSV' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'IgG2b' named entity 'mice' named entity 'titer' named entity 'immunogenic' named entity 'VSV' named entity 'mice' named entity 'RBD' named entity 'mice' named entity 'IgG' named entity 'murine' named entity 'ACE2' named entity 'viral RNA' named entity 'VSV' named entity 'IgG' named entity 'viral RNA' named entity 'SARS-CoV-2' named entity 'VSV' named entity 'eGFP' named entity 'eGFP' named entity 'RBD' named entity 'positive-sense' named entity 'SARS-CoV-2'

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