About: Bronchiectasis and cough: An old relationship in need of renewed attention

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Bronchiectasis and cough: An old relationship in need of renewed attention
Creator	Aogáin, M Aogáin, Micheál Chotirmall, Chotirmall, S Sanjay, Haresh
Source	Elsevier; Medline; PMC
abstract	Bronchiectasis is an increasingly recognised respiratory condition with limited therapeutic options and a complex spectrum of clinical manifestations that invariably includes chronic cough. As the primary presentation of bronchiectasis in most cases, chronic cough and its mechanistic underpinnings are of central importance but remain poorly understood in this setting. Bronchiectasis is also increasingly identified as an underlying cause of chronic cough highlighting the interrelationship between the two conditions that share overlapping clinical features. Several therapeutic approaches have illustrated positive effects on bronchiectasis-associated cough, however, more focused treatment of heterogeneous cough subtypes may yield better outcomes for patients. A current challenge is the identification of bronchiectasis and cough endophenotypes that may allow improved patient stratification and more targeted therapeutic matching of the right treatment to the right patient. Here we discuss the complex disease phenotypes of bronchiectasis and their interrelationship with cough while considering current and emerging treatment options. We discuss some key cough promoters in bronchiectasis including infection, allergy and immune dysfunction.
has issue date	2019-06-06(xsd:dateTime)
bibo:doi	10.1016/j.pupt.2019.101812
bibo:pmid	31176801
has license	no-cc
sha1sum (hex)	30d3ac84fd85ded68229c2c79ce13a189cf187f0
schema:url	https://doi.org/10.1016/j.pupt.2019.101812
resource representing a document's title	Bronchiectasis and cough: An old relationship in need of renewed attention
has PubMed Central identifier	PMC7110869
has PubMed identifier	31176801
schema:publication	Pulm Pharmacol Ther
resource representing a document's body	covid:30d3ac84fd85ded68229c2c79ce13a189cf187f0#body_text
is schema:about of	named entity 'central' named entity 'immune dysfunction' named entity 'mechanistic' named entity 'identified' named entity 'emerging' named entity 'approaches' named entity 'ATTENTION' named entity 'FOCUSED' named entity 'THEIR' named entity 'TO THE RIGHT' named entity 'OUTCOMES' named entity 'STRATIFICATION' named entity 'POORLY' named entity 'YIELD' named entity 'TARGETED' named entity 'ASSOCIATED' named entity 'PRESENTATION' named entity 'POSITIVE' named entity 'ALLOW' named entity 'PHENOTYPES' named entity 'IMPROVED' named entity 'TREATMENT' named entity 'BETTER' named entity 'DISCUSS' named entity 'SETTING' named entity 'OPTIONS' named entity 'AND COUGH' named entity 'CHRONIC COUGH' named entity 'OVERLAPPING' named entity 'APPROACHES' named entity 'ENDOPHENOTYPES' named entity 'UNDERLYING' named entity 'BUT' named entity 'ITS' named entity 'BRONCHIECTASIS' named entity 'NEED' named entity 'IMMUNE DYSFUNCTION' named entity 'COMPLEX DISEASE' named entity 'THERAPEUTIC' named entity 'SPECTRUM' named entity 'HAVE' named entity 'SUBTYPES' named entity 'CAUSE' named entity 'IDENTIFIED' named entity 'INFECTION' named entity 'CASES' named entity 'TREATMENT OPTIONS' named entity 'CHALLENGE' named entity 'PRIMARY' named entity 'COMPLEX' named entity 'LIMITED' named entity 'UNDERSTOOD' named entity 'CENTRAL' named entity 'PATIENTS' named entity 'A CURRENT' named entity 'COUGH' named entity 'CLINICAL MANIFESTATIONS' named entity 'MATCHING' named entity 'KEY' named entity 'IDENTIFICATION' named entity 'ALLERGY' named entity 'HERE' named entity 'HETEROGENEOUS' named entity 'PROMOTERS' named entity 'CHRONIC COUGH' named entity 'CONSIDERING' named entity 'CONDITIONS' named entity 'EFFECTS' named entity 'OLD' named entity 'RELATIONSHIP' named entity 'RIGHT' named entity 'INCLUDING' named entity 'CLINICAL FEATURES' named entity 'HIGHLIGHTING' named entity 'RESPIRATORY CONDITION' named entity 'CURRENT' named entity 'PATIENT'

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