About: Human Neutralizing Monoclonal Antibody Inhibition of Middle East Respiratory Syndrome Coronavirus Replication in the Common Marmoset

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About: Human Neutralizing Monoclonal Antibody Inhibition of Middle East Respiratory Syndrome Coronavirus Replication in the Common Marmoset Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Human Neutralizing Monoclonal Antibody Inhibition of Middle East Respiratory Syndrome Coronavirus Replication in the Common Marmoset
Creator	Cui, Sheng Qin, Chuan Jin, Qi Chen, Cong Wang, Jianmin Lv, Qi Bao, Linlin Chen, Zhe Xue, Ying Li, Fengdi Gao, Xiaopan Gu, Songzhi Zou, Tingting
Source	Medline; PMC
abstract	Middle East respiratory syndrome coronavirus (MERS-CoV) infection in humans is highly lethal, with a fatality rate of 35%. New prophylactic and therapeutic strategies to combat human infections are urgently needed. We isolated a fully human neutralizing antibody, MCA1, from a human survivor. The antibody recognizes the receptor-binding domain of MERS-CoV S glycoprotein and interferes with the interaction between viral S and the human cellular receptor human dipeptidyl peptidase 4 (DPP4). To our knowledge, this study is the first to report a human neutralizing monoclonal antibody that completely inhibits MERS-CoV replication in common marmosets. Monotherapy with MCA1 represents a potential alternative treatment for human infections with MERS-CoV worthy of evaluation in clinical settings.
has issue date	2017-06-15(xsd:dateTime)
bibo:doi	10.1093/infdis/jix209
bibo:pmid	28472421
has license	no-cc
sha1sum (hex)	30b4b3db4476c5df7a3797c56537a46b4db61eac
schema:url	https://doi.org/10.1093/infdis/jix209
resource representing a document's title	Human Neutralizing Monoclonal Antibody Inhibition of Middle East Respiratory Syndrome Coronavirus Replication in the Common Marmoset
has PubMed Central identifier	PMC7107363
has PubMed identifier	28472421
schema:publication	J Infect Dis
resource representing a document's body	covid:30b4b3db4476c5df7a3797c56537a46b4db61eac#body_text
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