About: Smp76, a Scorpine-Like Peptide Isolated from the Venom of the Scorpion Scorpio maurus palmatus, with a Potent Antiviral Activity Against Hepatitis C Virus and Dengue Virus

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About: Smp76, a Scorpine-Like Peptide Isolated from the Venom of the Scorpion Scorpio maurus palmatus, with a Potent Antiviral Activity Against Hepatitis C Virus and Dengue Virus Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Smp76, a Scorpine-Like Peptide Isolated from the Venom of the Scorpion Scorpio maurus palmatus, with a Potent Antiviral Activity Against Hepatitis C Virus and Dengue Virus
Creator	Hotta, Hak Abdel-Rahman, Mohamed Aoki-Utsubo, Chie Moustafa, Mohsen Sarhan, Moustafa Possani, Lourival El-Bitar, Alaa Moustafa, A Hak Hotta, · Lourival, · Mohsen, · Possani, D Quintero-Hernandez, Veronica
Source	PMC
abstract	Growing global viral infections have been a serious public health problem in recent years. This current situation emphasizes the importance of developing more therapeutic antiviral compounds. Hepatitis C virus (HCV) and dengue virus (DENV) belong to the Flaviviridae family and are an increasing global health threat. Our previous study reported that the crude venom of Scorpio maurus palmatus possessed anti-HCV and anti-DENV activities in vitro. We report here the characterization of a natural antiviral peptide (scorpion-like peptide Smp76) that prevents HCV and DENV infection. Smp76 was purified from S. m. palmatus venom and contains 76 amino acids with six residues of cysteine. Smp76 antiviral activity was evaluated using a cell culture technique utilizing Huh7it-1, Vero/SLAM, HCV (JFH1, genotype 2a) and DENV (Trinidad 1751, type 2). A potential antiviral activity of Smp76 was detected in culture cells with an approximate IC(50) of 0.01 μg/ml. Moreover, Smp76 prevents HCV infection and suppresses secondary infection, by inactivating extra-cellular infectious particles without affecting viral replication. Interestingly, Smp76 is neither toxic nor hemolytic in vitro at a concentration 1000-fold higher than that required for antiviral activity. Conclusively, this report highlights novel anti-HCV and anti-DENV activities of Smp76, which may lay the foundation for developing a new therapeutic intervention against these flaviviruses.
has issue date	2019-07-06(xsd:dateTime)
bibo:doi	10.1007/s10989-019-09888-2
bibo:pmid	32435168
has license	no-cc
sha1sum (hex)	30ac11a4580b79272e55dd4911aada1ecf72485c
schema:url	https://doi.org/10.1007/s10989-019-09888-2
resource representing a document's title	Smp76, a Scorpine-Like Peptide Isolated from the Venom of the Scorpion Scorpio maurus palmatus, with a Potent Antiviral Activity Against Hepatitis C Virus and Dengue Virus
has PubMed Central identifier	PMC7223391
has PubMed identifier	32435168
schema:publication	Int J Pept Res Ther
resource representing a document's body	covid:30ac11a4580b79272e55dd4911aada1ecf72485c#body_text
is schema:about of	named entity 'antiviral' named entity 'activity' named entity 'Venom' named entity 'Scorpion' named entity 'HAVE' named entity 'FAMILY' named entity 'INFECTION' named entity 'PUBLIC HEALTH' named entity 'TYPE 2' named entity 'SITUATION' named entity 'SLAM' named entity 'problem' named entity 'Vero' named entity 'Flaviviridae' named entity 'activities' named entity 'concentration' named entity 'natural' named entity 'therapeutic' named entity 'Peptide' named entity 'HCV' named entity 'infection' named entity 'amino acids' named entity 'peptide' named entity 'venom' named entity 'antiviral' named entity 'HCV' named entity 'HCV' named entity 'DENV' named entity 'Flaviviridae' named entity '0.01' named entity 'antiviral' named entity 'HCV' named entity 'Dengue Virus' named entity 'Antiviral Activity' named entity 'homologs' named entity 'Keyence' named entity 'microbicide' named entity 'Africa' named entity 'HCV' named entity 'DENV' named entity 'HCV' named entity 'Roche' named entity 'AMPs' named entity 'RNA' named entity 'hepatoma' named entity 'peptide' named entity 'MBP' named entity 'infection' named entity 'disulfide bonds' named entity 'peptide' named entity 'viral entry' named entity 'peptides' named entity 'single-stranded RNA' named entity 'protein' named entity 'immunofluorescence assay' named entity 'oligonucleotides' named entity 'cultured cell' named entity 'hemolysis' named entity 'Protein' named entity 'antiviral activity' named entity 'recombinant' named entity 'Pandinus imperator' named entity 'HCV' named entity 'measles virus' named entity 'protein' named entity 'microplate reader' named entity 'C-terminal' named entity 'California' named entity 'HCV'

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