About: Systematic, active surveillance for Middle East respiratory syndrome coronavirus in camels in Egypt

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About: Systematic, active surveillance for Middle East respiratory syndrome coronavirus in camels in Egypt Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Systematic, active surveillance for Middle East respiratory syndrome coronavirus in camels in Egypt
Creator	Kayali, Ghazi Bagato, Ola El-Shesheny, Rabeh Gomaa, Mokhtar Hassan, Nagla Kandeil, Ahmed Kutkat, Omnia Mahmoud, Sara El-Taweel, Ahmed Moatasim, Yassmin Shehata, Mahmoud Webby, Richard Ali, Mohamed Osman, Ahmed Atea, Mohamed Kayed, Ahmed Maatouq, Asmaa Mckenzie, Pamela
Source	Medline; PMC
abstract	Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe human infections and dromedary camels are considered an intermediary host. The dynamics of natural infection in camels are not well understood. Through systematic surveillance in Egypt, nasal, rectal, milk, urine and serum samples were collected from camels between June 2014 and February 2016. Locations included quarantines, markets, abattoirs, free-roaming herds and farmed breeding herds. The overall seroprevalence was 71% and RNA detection rate was 15%. Imported camels had higher seroprevalence (90% vs 61%) and higher RT-PCR detection rates (21% vs 12%) than locally raised camels. Juveniles had lower seroprevalence than adults (37% vs 82%) but similar RT-PCR detection rates (16% vs 15%). An outbreak in a breeding herd, showed that antibodies rapidly wane, that camels become re-infected, and that outbreaks in a herd are sustained for an extended time. Maternal antibodies titers were very low in calves regardless of the antibody titers of the mothers. Our results support the hypothesis that camels are a reservoir for MERS-CoV and that camel trade is an important route of introducing the virus into importing countries. Findings related to waning antibodies and re-infection have implications for camel vaccine development, disease management and zoonotic threat.
has issue date	2017-01-04(xsd:dateTime)
bibo:doi	10.1038/emi.2016.130
bibo:pmid	28050021
has license	cc-by
sha1sum (hex)	307179cebf2bf9f9107f745af8f2899db6c51ca9
schema:url	https://doi.org/10.1038/emi.2016.130
resource representing a document's title	Systematic, active surveillance for Middle East respiratory syndrome coronavirus in camels in Egypt
has PubMed Central identifier	PMC5285495
has PubMed identifier	28050021
schema:publication	Emerg Microbes Infect
resource representing a document's body	covid:307179cebf2bf9f9107f745af8f2899db6c51ca9#body_text
is schema:about of	named entity 'collected' named entity 'camels' named entity 'herds' named entity 'FINDINGS' named entity 'BREEDING' named entity 'ZOONOTIC' named entity 'SAMPLES' named entity 'IMPORTED' named entity 'DISEASE MANAGEMENT' named entity 'WANING' named entity 'SUSTAINED' named entity 'CAUSES' named entity 'QUARANTINES' named entity 'SUPPORT' named entity 'OUR' named entity 'ADULTS' named entity 'REGARDLESS' named entity 'DYNAMICS' named entity 'DROMEDARY' named entity 'NOT WELL' named entity 'UNDERSTOOD' named entity 'THREAT' named entity 'MATERNAL' named entity 'BUT' named entity 'LOCALLY' named entity 'TIME' named entity 'EXTENDED' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'MARKETS' named entity 'RATE' named entity 'RAISED' named entity 'SEVERE' named entity 'HAVE' named entity 'CONSIDERED' named entity 'DETECTION' named entity 'RELATED' named entity 'COLLECTED' named entity 'VACCINE DEVELOPMENT' named entity 'COUNTRIES' named entity 'SERUM' named entity 'CAMELS' named entity 'HERD' named entity 'ANTIBODY TITERS' named entity 'FREE' named entity 'TRADE' named entity 'RT-PCR' named entity 'ABATTOIRS' named entity 'SURVEILLANCE' named entity 'HIGHER' named entity 'OVERALL' named entity 'RESERVOIR' named entity 'RESULTS' named entity 'HYPOTHESIS' named entity 'MOTHERS' named entity 'CAMEL' named entity 'HUMAN' named entity 'MICROBES' named entity 'JUNE' named entity 'RECTAL' named entity 'VIRUS' named entity 'FEBRUARY' named entity 'LOCATIONS' named entity 'LOWER' named entity 'IMPORTANT'

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