About: Detection of Severe Acute Respiratory Syndrome Coronavirus in the Brain: Potential Role of the Chemokine Mig in Pathogenesis

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About: Detection of Severe Acute Respiratory Syndrome Coronavirus in the Brain: Potential Role of the Chemokine Mig in Pathogenesis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Detection of Severe Acute Respiratory Syndrome Coronavirus in the Brain: Potential Role of the Chemokine Mig in Pathogenesis
Creator	Xu, Jun Zhong, Nanshan Li, Zhijie Li, Li Jiang, Yong Wu, Xinwei Li, Yong Zhang, Jingqiang Deng, Peng Liu, Jinghua Ding, Yanqing Zhong, Shuqing
source	Medline; PMC
abstract	Background. Previous studies have shown that common human coronavirus might be neurotropic, although it was first isolated as a pathogen of the respiratory tract. We noticed that a few patients with severe acute respiratory syndrome (SARS) experienced central nervous symptoms during the course of illness. In the present study, we isolated a SARS coronavirus strain from a brain tissue specimen obtained from a patient with SARS with significant central nervous symptoms. Methods. Using transmission electronic microscopy and nested reverse transcription–polymerase chain reaction, the causative pathogen was identified in cultures of a brain tissue specimen obtained from the patient with SARS. Histopathologic examination of the brain tissue was performed using the methods of immunohistochemistry analysis and double immunofluorescence staining. Fifteen cytokines and chemokines were detected in the blood of the patient with SARS by means of a bead-based multiassay system. Results. A fragment specific for SARS human coronavirus was amplified from cultures of the brain suspension, and transmission electronic microscopy revealed the presence of an enveloped virus morphologically compatible with a coronavirus isolated in the cultures. Pathologic examination of the brain tissue revealed necrosis of neuron cells and broad hyperplasia of gliocytes. Immunostaining demonstrated that monokine induced by interferon-Γ (Mig) was expressed in gliocytes with the infiltration of CD68(+) monocytes/macrophages and CD3(+) T lymphocytes in the brain mesenchyme. Cytokine/chemokine assay revealed that levels of interferon-Γ–inducible protein 10 and Mig in the blood were highly elevated, although the levels of other cytokines and chemokines were close to normal. Conclusions. This study provides direct evidence that SARS human coronavirus is capable of infecting the central nervous system, and that Mig might be involved in the brain immunopathology of SARS.
has issue date	2005-10-15(xsd:dateTime)
bibo:doi	10.1086/444461
bibo:pmid	16163626
has license	no-cc
sha1sum (hex)	306145655e3e9adaf8ceceed760b8372292fae8e
schema:url	https://doi.org/10.1086/444461
resource representing a document's title	Detection of Severe Acute Respiratory Syndrome Coronavirus in the Brain: Potential Role of the Chemokine Mig in Pathogenesis
has PubMed Central identifier	PMC7107994
has PubMed identifier	16163626
schema:publication	Clin Infect Dis
resource representing a document's body	covid:306145655e3e9adaf8ceceed760b8372292fae8e#body_text
is schema:about of	named entity 'CHEMOKINE' named entity 'cultures' named entity 'causative' named entity 'chain reaction' named entity 'OCTOBER' named entity '80%' named entity 'SARS' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS' named entity 'CID' named entity 'NEUROTROPIC' named entity 'CENTRAL' named entity 'ELECTRONIC' named entity 'THE BRAIN' named entity 'BLOOD' named entity 'NESTED' named entity 'MIGHT BE' named entity 'HAVE' named entity 'PERFORMED' named entity 'PATIENTS' named entity 'PRESENT' named entity 'STRAIN' named entity 'DETECTED' named entity 'IMMUNOHISTOCHEMISTRY' named entity 'REVERSE TRANSCRIPTION' named entity 'ANALYSIS' named entity 'IMMUNOFLUORESCENCE STAINING' named entity 'EXPERIENCED' named entity 'MIG' named entity 'TRANSMISSION' named entity 'STUDIES' named entity 'COURSE OF ILLNESS' named entity 'FIFTEEN' named entity 'THE BRAIN' named entity 'POTENTIAL' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'BASED' named entity 'HISTOPATHOLOGIC EXAMINATION' named entity 'SYSTEM' named entity 'DOUBLE' named entity 'SIGNIFICANT' named entity 'PREVIOUS' named entity 'POLYMERASE CHAIN REACTION' named entity 'CAUSED BY' named entity 'BRAIN DAMAGE' named entity 'MEDIATOR' named entity 'CHEMOKINES' named entity 'BEAD' named entity 'CULTURES' named entity 'HUMAN CORONAVIRUS' named entity 'NERVOUS SYMPTOMS' named entity 'SARS CORONAVIRUS' named entity 'PATHOGEN' named entity 'PATIENT' named entity 'BRAIN TISSUE' named entity 'RESPIRATORY TRACT' named entity 'MICROSCOPY' named entity 'SPECIMEN OBTAINED' named entity 'CYTOKINES' named entity 'ISOLATED' named entity 'USING' named entity 'METHODS' named entity 'IDENTIFIED' named entity 'STUDY' named entity 'TISSUE SPECIMEN' named entity 'ROLE' named entity 'PATHOGENESIS' named entity 'COMMON' named entity 'SARS' named entity 'DETECTION' named entity 'MEANS'

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