About: Molecular epidemiology and environmental contamination during an outbreak of parainfluenza virus 3 in a haematology ward

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Molecular epidemiology and environmental contamination during an outbreak of parainfluenza virus 3 in a haematology ward
Creator	Lee, K.-H Choi, S.-H Chong, Y Kim, J Kim, S.-H Kim, Y Lee, J.-H Lee, S.-O Park, J Sung, H Woo, J Jin, C Kim, S.-M Kim, T Koo, B Shin, Y
source	Elsevier; Medline; PMC
abstract	Summary Background Although fomites or contaminated surfaces have been considered as transmission routes, the role of environmental contamination by human parainfluenza virus type 3 (hPIV-3) in healthcare settings is not established. Aim To describe an hPIV-3 nosocomial outbreak and the results of environmental sampling to elucidate the source of nosocomial transmission and the role of environmental contamination. Methods During an hPIV-3 outbreak between May and June 2016, environmental surfaces in contact with clustered patients were swabbed and respiratory specimens used from infected patients and epidemiologically unlinked controls. The epidemiologic relatedness of hPIV-3 strains was investigated by sequencing of the haemagglutinin–neuraminidase and fusion protein genes. Findings Of 19 hPIV-3-infected patients, eight were haematopoietic stem cell recipients and one was a healthcare worker. In addition, four had upper and 12 had lower respiratory tract infections. Of the 19 patients, six (32%) were community-onset infections (symptom onset within <7 days of hospitalization) and 13 (68%) were hospital-onset infections (≥7 days of hospitalization). Phylogenetic analysis identified two major clusters: five patients, and three patients plus one healthcare worker. Therefore, seven (37%) were classified as nosocomial transmissions. hPIV-3 was detected in 21 (43%) of 49 environmental swabs up to 12 days after negative respiratory polymerase chain reaction conversion. Conclusion At least one-third of a peak season nosocomial hPIV-3 outbreak originated from nosocomial transmission, with multiple importations of hPIV-3 from the community, providing experimental evidence for extensive environmental hPIV-3 contamination. Direct contact with the contaminated surfaces and fomites or indirect transmission from infected healthcare workers could be responsible for nosocomial transmission.
has issue date	2017-12-31(xsd:dateTime)
bibo:doi	10.1016/j.jhin.2017.09.003
bibo:pmid	28893615
has license	els-covid
sha1sum (hex)	2ff940ef204a3572ed71f29123f221f199edcb2d
schema:url	https://doi.org/10.1016/j.jhin.2017.09.003
resource representing a document's title	Molecular epidemiology and environmental contamination during an outbreak of parainfluenza virus 3 in a haematology ward
has PubMed Central identifier	PMC7114920
has PubMed identifier	28893615
schema:publication	Journal of Hospital Infection
resource representing a document's body	covid:2ff940ef204a3572ed71f29123f221f199edcb2d#body_text
is schema:about of	named entity 'Molecular epidemiology' named entity 'ENVIRONMENTAL CONTAMINATION' named entity 'OUTBREAK' named entity 'HAEMATOLOGY' named entity 'PARAINFLUENZA VIRUS 3' named entity 'MOLECULAR EPIDEMIOLOGY' named entity 'WARD' named entity 'Molecular epidemiology' named entity 'parainfluenza virus 3' named entity 'haematology' named entity 'Dacron' named entity 'haematology' named entity 'epidemiology' named entity 'nucleotide' named entity 'morbidity' named entity 'Asan Medical Center' named entity 'scientific evidence' named entity 'immunocompromised' named entity 'PCR' named entity 'gene' named entity 'epidemiologically' named entity 'remote control' named entity 'Human parainfluenza viruses' named entity 'confidence interval' named entity 'infectivity' named entity 'stethoscopes' named entity 'transport medium' named entity 'isolation room' named entity 'B virus' named entity 'serotypes' named entity 'malignancies' named entity 'PCR' named entity 'fomites' named entity 'epidemiology' named entity 'nasal prongs' named entity 'aspirates' named entity 'control patients' named entity 'haematology' named entity 'lower respiratory tract infections' named entity 'human metapneumovirus' named entity 'viral RNA' named entity 'sputum' named entity '229E' named entity 'nosocomial' named entity 'infection' named entity 'virus' named entity 'fusion protein' named entity 'rhinorrhoea' named entity 'healthcare worker' named entity 'epidemiologically' named entity 'haematology' named entity 'gene' named entity 'LRTI' named entity 'viral shedding' named entity 'pathogens' named entity 'malignancies' named entity 'haematopoietic stem cell transplantation' named entity 'galactomannan' named entity 'contaminated surfaces' named entity 'polymerase chain reaction' named entity 'healthcare workers' named entity 'aseptically' named entity 'agarose gel electrophoresis' named entity 'nosocomial' named entity 'disinfection' named entity 'immunocompromised host'

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