About: Clinical course and prognostic factors of COVID-19 infection in an elderly hospitalized population

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About: Clinical course and prognostic factors of COVID-19 infection in an elderly hospitalized population Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical course and prognostic factors of COVID-19 infection in an elderly hospitalized population
Creator	Blanco, Francisco Cachán, María Estirado, Eva García-Iglesias, Francisca González-Alegre, Teresa Hernández-Blanco, Clara Hontañón, Victor Jaras-Hernández, María Lahoz, Carlos Martínez-Prieto, Mónica Menéndez-Saldaña, Araceli Mostaza, Jose Varas, Marta
Source	Elsevier; Medline; PMC
abstract	INTRODUCTION: Older subjects have a higher risk of COVID-19 infection and a greater mortality. However, there is a lack of studies evaluating the characteristics of this infection at advanced age. PATIENTS AND METHODS: We studied 404 patients ≥ 75 years (mean age 85.2 ± 5.3 years, 55% males), with PCR-confirmed COVID-19 infection, attended in two hospitals in Madrid (Spain). Patients were followed-up until they were discharged from the hospital or until death. RESULTS: Symptoms started 2 to 7 days before admission, and consisted of fever (64%), cough (59%), and dyspnea (57%). A total of 145 patients (35.9%) died a median of 9 days after hospitalization. In logistic regression analysis, predictive factors of death were age (OR 1.086; 1.015-1.161 per year, p = 0.016), heart rate (1.040; 1.018-1.061 per beat, p < 0.0001), a decline in renal function during hospitalization (OR 7.270; 2.586-20.441, p < 0.0001) and worsening dyspnea during hospitalization (OR 73.616; 30.642-176.857, p < 0.0001). Factors predicting survival were a female sex (OR 0.271; 0.128-0.575, p = 0.001), previous treatment with RAAS inhibitors (OR 0.459; 0.222-0.949, p = 0.036), a higher oxygen saturation at admission (OR 0.901; 0.842-0.963 per percentage point increase, p = 0.002), and a greater platelet count (OR 0.995; 0.991-0.999 per 10(6)/L, p = 0.025). CONCLUSION: Elderly patients with COVID-19 infection have a similar clinical course to younger individuals. Previous treatment with RAAS inhibitors, and demographic, clinical and laboratory data influence prognosis.
has issue date	2020-07-27(xsd:dateTime)
bibo:doi	10.1016/j.archger.2020.104204
bibo:pmid	32771883
has license	no-cc
sha1sum (hex)	2ff5ededdbc5cee27e7131873851eda1bcf475d2
schema:url	https://doi.org/10.1016/j.archger.2020.104204
resource representing a document's title	Clinical course and prognostic factors of COVID-19 infection in an elderly hospitalized population
has PubMed Central identifier	PMC7383171
has PubMed identifier	32771883
schema:publication	Arch Gerontol Geriatr
resource representing a document's body	covid:2ff5ededdbc5cee27e7131873851eda1bcf475d2#body_text
is schema:about of	named entity 'administration' named entity 'Writing' named entity 'factors' named entity 'Varas' named entity 'Writing' named entity 'Investigation' named entity 'Data curation' named entity 'infection' named entity 'chronic renal failure' named entity 'immunoregulation' named entity 'prognosis' named entity 'ARDS' named entity 'renal failure' named entity 'COVID-19 infection' named entity 'creatinine' named entity 'cough' named entity 'immunosuppressive treatment' named entity 'neutrophils' named entity 'LDH' named entity 'arrhythmia' named entity 'CRP' named entity 'dyspnea' named entity 'mmHg' named entity 'older patients' named entity 'follow-up' named entity 'immunological responses' named entity 'PCR' named entity 'platelet count' named entity 'RAAS' named entity 'CRP' named entity 'older age' named entity 'nasal congestion' named entity 'respiratory failure' named entity 'older age' named entity 'platelet count' named entity 'ARDS' named entity 'Mortality rate' named entity 'Demographic' named entity 'oxygen saturation' named entity 'hypertension' named entity 'ARDS' named entity 'inflammatory response' named entity 'hypertension' named entity 'ischemic' named entity 'comorbidities' named entity 'nausea' named entity 'comorbidities' named entity 'AST' named entity 'prognosis' named entity 'comorbidities' named entity 'platelet count' named entity 'oxygen saturation' named entity 'fraction of inspired oxygen' named entity 'dyspnea' named entity 'ICU' named entity 'renal function' named entity 'May 10' named entity 'Fever' named entity 'oxygen saturation' named entity '90/60' named entity 'elderly people' named entity 'shortness of breath' named entity 'RAAS' named entity 'diarrhea' named entity 'cough' named entity 'regression analysis' named entity 'emergency ward' named entity 'COVID-19 infection' named entity 'congestive heart failure'

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