About: Enhancement of the immunogenicity of an infectious bronchitis virus DNA vaccine by a bicistronic plasmid encoding nucleocapsid protein and interleukin-2

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About: Enhancement of the immunogenicity of an infectious bronchitis virus DNA vaccine by a bicistronic plasmid encoding nucleocapsid protein and interleukin-2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Enhancement of the immunogenicity of an infectious bronchitis virus DNA vaccine by a bicistronic plasmid encoding nucleocapsid protein and interleukin-2
Creator	Zhou, Sheng Wang, Hongning Tang, Mengjun Tian, Guobao
Source	Elsevier; Medline; PMC
abstract	A DNA vaccine against infectious bronchitis virus (IBV) can induce specific humoral and cell-mediated immunity. However, compared to conventional vaccines, DNA vaccines usually induce poor antibody responses. To develop a more potent IBV DNA vaccine formulations, a monocistronic vector encoding the nucleocapsid protein of IBV and a bicistronic vector separately encoding the nucleocapsid protein and immune-stimulatory interleukin-2 were constructed. When the DNA vaccines were administered to the quadriceps muscle of chickens, the induced humoral and cellular responses were evaluated. There was a significant difference in ELISA antibody levels elicited by either monocistronic or bicistronic DNA vaccines. The percentage of CD3(+), CD3(+)CD8(+) and CD3(+)CD4(+) subgroups of peripheral blood T-lymphocytes in chickens immunized with bicistronic DNA vaccine were higher than those in chickens immunized with monocistronic DNA vaccine. When chickens were challenged with a virulent strain of IBV, the protective efficacy could be enhanced significantly after immunization with bicistronic DNA vaccine. These results demonstrated that bicistronic DNA vaccine is an effective approach to increase IBV DNA vaccine immunogenicity.
has issue date	2008-03-07(xsd:dateTime)
bibo:doi	10.1016/j.jviromet.2008.01.017
bibo:pmid	18329109
has license	no-cc
sha1sum (hex)	2feee102eda67b8b2839d523ecb483ad42b53bd7
schema:url	https://doi.org/10.1016/j.jviromet.2008.01.017
resource representing a document's title	Enhancement of the immunogenicity of an infectious bronchitis virus DNA vaccine by a bicistronic plasmid encoding nucleocapsid protein and interleukin-2
has PubMed Central identifier	PMC7119663
has PubMed identifier	18329109
schema:publication	J Virol Methods
resource representing a document's body	covid:2feee102eda67b8b2839d523ecb483ad42b53bd7#body_text
is schema:about of	named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'ENHANCEMENT' named entity 'potent' named entity 'There' named entity 'cellular' named entity 'induced' named entity 'chickens' named entity 'monocistronic' named entity 'IBV' named entity 'antibody' named entity 'infectious bronchitis' named entity 'IMMUNOGENICITY' named entity 'IMMUNIZED' named entity 'A DNA' named entity 'DNA VACCINE' named entity 'CD8' named entity 'EFFECTIVE' named entity 'THESE' named entity 'DIFFERENCE' named entity 'CONVENTIONAL' named entity 'HIGHER' named entity 'PERCENTAGE' named entity 'PROTEIN ' named entity 'DEMONSTRATED' named entity 'CD4' named entity 'SIGNIFICANT' named entity 'EVALUATED' named entity 'IMMUNOGENICITY' named entity 'VACCINES' named entity 'COMPARED' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'IMMUNIZATION' named entity 'VECTOR' named entity 'INTERLEUKIN-2 ' named entity 'CONSTRUCTED' named entity 'EITHER' named entity 'SPECIFIC' named entity 'RESULTS' named entity 'CELL-MEDIATED IMMUNITY' named entity 'RESPONSES' named entity 'TO INCREASE' named entity 'MONOCISTRONIC' named entity 'INDUCED' named entity 'NUCLEOCAPSID PROTEIN' named entity 'COULD BE' named entity 'CD3' named entity 'POOR' named entity 'USUALLY' named entity 'ANTIBODY' named entity 'CELLULAR' named entity 'ELICITED BY' named entity 'ELISA' named entity 'T-LYMPHOCYTES' named entity 'DNA VACCINE' named entity 'INTERLEUKIN-2' named entity 'PROTEIN ' named entity 'ENCODING' named entity 'VIRULENT STRAIN' named entity 'INDUCE' named entity 'EFFICACY' named entity 'QUADRICEPS MUSCLE' named entity 'ENCODING' named entity 'SUBGROUPS' named entity 'CHICKENS' named entity 'LEVELS' named entity 'WAS A' named entity 'NUCLEOCAPSID PROTEIN' named entity 'PERIPHERAL BLOOD' named entity 'APPROACH' named entity 'ADMINISTERED' named entity 'DNA VACCINES' named entity 'ENHANCED' named entity 'VIRUS DNA' named entity 'PLASMID' covid:arg/2feee102eda67b8b2839d523ecb483ad42b53bd7 named entity 'quadriceps muscle' named entity 'infectious bronchitis' named entity 'bicistronic'

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