About: Mechanism of inhibiting type I interferon induction by hepatitis B virus X protein

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mechanism of inhibiting type I interferon induction by hepatitis B virus X protein
Creator	Tang, Hong Jiang, Junyi
Source	Medline; PMC
abstract	Hepatitis B virus (HBV) is regarded as a stealth virus, invading and replicating efficiently in human liver undetected by host innate antiviral immunity. Here, we show that type I interferon (IFN) induction but not its downstream signaling is blocked by HBV replication in HepG2.2.15 cells. This effect may be partially due to HBV X protein (HBx), which impairs IFNβ promoter activation by both Sendai virus (SeV) and components implicated in signaling by viral sensors. As a deubiquitinating enzyme (DUB), HBx cleaves Lys63-linked polyubiquitin chains from many proteins except TANK-binding kinase 1 (TBK1). It binds and deconjugates retinoic acid-inducible gene I (RIG I) and TNF receptor-associated factor 3 (TRAF3), causing their dissociation from the downstream adaptor CARDIF or TBK1 kinase. In addition to RIG I and TRAF3, HBx also interacts with CARDIF, TRIF, NEMO, TBK1, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon (IKKi) and interferon regulatory factor 3 (IRF3). Our data indicate that multiple points of signaling pathways can be targeted by HBx to negatively regulate production of type I IFN. ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s13238-010-0141-8 and is accessible for authorized users.
has issue date	2011-01-08(xsd:dateTime)
bibo:doi	10.1007/s13238-010-0141-8
bibo:pmid	21213104
has license	no-cc
sha1sum (hex)	2fccf11537c01e016013bf21914363768e8505d6
schema:url	https://doi.org/10.1007/s13238-010-0141-8
resource representing a document's title	Mechanism of inhibiting type I interferon induction by hepatitis B virus X protein
has PubMed Central identifier	PMC4875076
has PubMed identifier	21213104
schema:publication	Protein Cell
resource representing a document's body	covid:2fccf11537c01e016013bf21914363768e8505d6#body_text
is schema:about of	named entity 'HBx' named entity 'SeV' named entity 'deubiquitinating enzyme' named entity 'TANK-binding kinase 1' named entity 'HBx' named entity 'light' named entity 'HUMAN LIVER' named entity 'CLEAVES' named entity 'CELLS' named entity 'TYPE I INTERFERON' named entity 'IFN' named entity 'RETINOIC ACID' named entity 'gene' named entity 'TRAF3' named entity 'TBK1' named entity 'innate' named entity 'HBV' named entity 'stealth' named entity 'points' named entity 'interferon' named entity 'replication' named entity 'host' named entity 'causing' named entity 'IFNβ' named entity 'inhibiting' named entity 'innate antiviral immunity' named entity 'human liver' named entity 'HBx' named entity 'TNF receptor-associated factor 3' named entity 'HBx' named entity 'gene enhancer' named entity 'IFNβ' named entity 'type I IFN' named entity 'IFN' named entity 'stealth virus' named entity 'signaling pathways' named entity 'kinase' named entity 'HBV' named entity 'deubiquitinating enzyme' named entity 'hepatitis B virus' named entity 'dissociation' named entity 'NEMO' named entity 'genome' named entity 'nuclear factor-kappaB' named entity 'dimerization' named entity 'type I IFN' named entity 'IRF3' named entity 'HBx' named entity 'TRIM25' named entity 'dimerization' named entity 'type I IFN' named entity 'HBx' named entity 'ubiquitin' named entity 'Coronaviruses' named entity 'green fluorescent protein' named entity 'HepG2' named entity 'retinoic acid' named entity 'MDA5' named entity 'deubiquitinating enzyme' named entity 'HBx' named entity 'HBV' named entity 'Assay' named entity 'HepG2' named entity 'TBK1' named entity 'nucleotide oligomerization domain' named entity 'STAT1' named entity 'GST' named entity 'Reaction products' named entity 'ubiquitin' named entity 'methyltransferase' named entity 'lysis buffer' named entity 'HBx' named entity 'HBx' named entity 'infection' named entity 'transcription' named entity 'glutathione' named entity 'pathogens' named entity 'HEK293T cells' named entity 'ubiquitination' named entity 'ubiquitination'

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