About: Stem cell-based Lung-on-Chips: The best of both worlds?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Stem cell-based Lung-on-Chips: The best of both worlds?
Creator	Hiemstra, Pieter Barrile, Riccardo Conegliano, David Nawroth, Janna Van Riet, Sander Villenave, Remi
Source	Elsevier; Medline; PMC
abstract	Abstract Pathologies of the respiratory system such as lung infections, chronic inflammatory lung diseases, and lung cancer are among the leading causes of morbidity and mortality, killing one in six people worldwide. Development of more effective treatments is hindered by the lack of preclinical models of the human lung that can capture the disease complexity, highly heterogeneous disease phenotypes, and pharmacokinetics and pharmacodynamics observed in patients. The merger of two novel technologies, Organs-on-Chips and human stem cell engineering, has the potential to deliver such urgently needed models. Organs-on-Chips, which are microengineered bioinspired tissue systems, recapitulate the mechanochemical environment and physiological functions of human organs while concurrent advances in generating and differentiating human stem cells promise a renewable supply of patient-specific cells for personalized and precision medicine. Here, we discuss the challenges of modeling human lung pathophysiology in vitro, evaluate past and current models including Organs-on-Chips, review the current status of lung tissue modeling using human pluripotent stem cells, explore in depth how stem-cell based Lung-on-Chips may advance disease modeling and drug testing, and summarize practical consideration for the design of Lung-on-Chips for academic and industry applications.
has issue date	2019-02-01(xsd:dateTime)
bibo:doi	10.1016/j.addr.2018.07.005
bibo:pmid	30009883
has license	els-covid
sha1sum (hex)	2f6704757eb7997842cf68d55dcc1206e4003bb5
schema:url	https://doi.org/10.1016/j.addr.2018.07.005
resource representing a document's title	Stem cell-based Lung-on-Chips: The best of both worlds?
has PubMed Central identifier	PMC7172977
has PubMed identifier	30009883
schema:publication	Advanced Drug Delivery Reviews
resource representing a document's body	covid:2f6704757eb7997842cf68d55dcc1206e4003bb5#body_text
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