About: Diagnosis of severe scrub typhus infection by next-generation sequencing:a case report

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Diagnosis of severe scrub typhus infection by next-generation sequencing:a case report
Creator	Ruan, Zhan-Wei Chen, Rui Chen, Jie Cui, Peng Dai, Qi-He Li, You-Peng Mo, Xiao-Jie Ye, Bing-Bing Zheng, Xu-Dong
Source	PMC
abstract	BACKGROUND: Scrub typhus is an acute febrile illness, which was caused by Orientia tsutsugamushi and transmitted through the bite of chiggers. The diagnosis of scrub typhus could be missed diagnosis due to the absence of the pathognomonic eschar. CASE PRESENTATION: A 76-year-old man was hospitalized with fever and kidney injury and was diagnosed of hemorrhagic fever with renal syndrome first. However, the situation of the illness deteriorated into refractory septic shock and multiple organ dysfunction rapidly,although the treatment of anti-sepsis was used in 3rd-5th day. Orientia tsutsugamushi was determined to be the causative pathogen by Next-generation sequencing of his plasma sample in 6th day. Then, the patient was treated with doxycycline and azithromycin and recovered quickly. CONCLUSIONS: Next-generation sequencing was a new diagnostic technology and could identify scrub typhus in accurately and fast without the pathognomonic eschar.
has issue date	2020-04-07(xsd:dateTime)
bibo:doi	10.1186/s12879-020-04991-y
bibo:pmid	32264829
has license	cc-by
sha1sum (hex)	2f53957baf0d35623ad97fd89c434e305aa54cc4
schema:url	https://doi.org/10.1186/s12879-020-04991-y
resource representing a document's title	Diagnosis of severe scrub typhus infection by next-generation sequencing:a case report
has PubMed Central identifier	PMC7137524
has PubMed identifier	32264829
schema:publication	BMC Infect Dis
resource representing a document's body	covid:2f53957baf0d35623ad97fd89c434e305aa54cc4#body_text
is schema:about of	named entity 'presentation' named entity 'severe' named entity 'Diagnosis' named entity 'ACUTE FEBRILE ILLNESS' named entity '6TH' named entity 'FAST' named entity 'kidney' named entity 'hemorrhagic fever' named entity 'azithromycin' named entity 'illness' named entity 'scrub typhus' named entity 'diagnosis' named entity 'determined' named entity 'eschar' named entity 'illness' named entity 'accurately' named entity 'next-generation sequencing' named entity 'kidney injury' named entity 'scrub typhus' named entity 'fever' named entity 'pathognomonic' named entity 'hemorrhagic fever with renal syndrome' named entity 'scrub typhus' named entity 'PCR' named entity 'pancreatitis' named entity 'plasma' named entity 'septic shock' named entity 'doxycycline' named entity 'pathogen' named entity 'diagnostic methods' named entity 'scrub typhus' named entity 'bacteria' named entity 'multiple organ dysfunction' named entity 'alanine aminotransferase' named entity 'coughing' named entity 'eschar' named entity 'pathogens' named entity 'TNF-α' named entity 'primer' named entity 'acute renal failure' named entity 'pseudomonas' named entity 'platelet' named entity 'NGS' named entity 'haemorrhagic fever with renal syndrome' named entity 'mice' named entity 'airway' named entity 'NGS' named entity 'serum creatinine' named entity 'Tissue biopsy' named entity 'intestinal absorption' named entity 'Orientia tsutsugamushi' named entity 'genome' named entity 'eschar' named entity 'Asia-Pacific' named entity 'Acinetobacter' named entity 'MODS' named entity 'antibody' named entity 'NGS' named entity 'Orientia tsutsugamushi' named entity 'urine' named entity 'indirect fluorescent antibody' named entity 'parasites' named entity 'platelet' named entity 'NGS' named entity 'Human Immunodeficiency Virus' named entity 'MODS' named entity 'bone marrow' named entity 'follow-up' named entity 'staphylococcus' named entity 'sputum' named entity 'epidemic' named entity 'serum creatinine' named entity 'antibiotics'

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