About: Clinical features of human metapneumovirus genotypes in children with acute lower respiratory tract infection in Changsha, China

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical features of human metapneumovirus genotypes in children with acute lower respiratory tract infection in Changsha, China
Creator	Duan, Zhao-Jun Zhang, Bing Xiao, Ni-Guang Yu, Tian Zeng, Sai-Zhen Zhong, Li-Li
Source	Medline; PMC
abstract	To explore the epidemiological and clinical features of different human metapneumovirus (hMPV) genotypes in hospitalized children. Reverse transcription polymerase chain reaction (RT‐PCR) or PCR was employed to screen for both hMPV and other common respiratory viruses in 2613 nasopharyngeal aspirate specimens collected from children with lower respiratory tract infections from September 2007 to February 2011 (a period of 3.5 years). The demographics and clinical presentations of patients infected with different genotypes of hMPV were compared. A total of 135 samples were positive for hMPV (positive detection rate: 5.2%). Co‐infection with other viruses was observed in 45.9% (62/135) of cases, and human bocavirus was the most common additional respiratory virus. The most common symptoms included cough, fever, and wheezing. The M gene was sequenced for 135 isolates; of these, genotype A was identified in 72.6% (98/135) of patients, and genotype B was identified in 27.4% (37/135) of patients. The predominant genotype of hMPV changed over the 3.5‐year study period from genotype A2b to A2b or B1 and then to predominantly B1. Most of clinical features were similar between patients infected with different hMPV genotypes. These results suggested that hMPV is an important viral pathogen in pediatric patients with acute lower respiratory tract infection in Changsha. The hMPV subtypes A2b and B1 were found to co‐circulate. The different hMPV genotypes exhibit similar clinical characteristics. J. Med. Virol. 87:1839–1845, 2015. © 2015 Wiley Periodicals, Inc.
has issue date	2015-05-14(xsd:dateTime)
bibo:doi	10.1002/jmv.24249
bibo:pmid	25950091
has license	no-cc
sha1sum (hex)	2ed419ef5b9e2d4ba54f2f64a39c34cd06917431
schema:url	https://doi.org/10.1002/jmv.24249
resource representing a document's title	Clinical features of human metapneumovirus genotypes in children with acute lower respiratory tract infection in Changsha, China
has PubMed Central identifier	PMC7167189
has PubMed identifier	25950091
schema:publication	J Med Virol
resource representing a document's body	covid:2ed419ef5b9e2d4ba54f2f64a39c34cd06917431#body_text
is schema:about of	named entity 'respiratory' named entity 'genotypes' named entity 'human metapneumovirus' named entity 'respiratory tract infections' named entity 'infected' named entity 'genotype' named entity 'RT-PCR' named entity 'total' named entity 'epidemiological' named entity 'samples' named entity 'viruses' named entity 'isolates' named entity 'Features' named entity 'lower respiratory tract infection' named entity 'cough' named entity 'gene' named entity 'PCR' named entity 'hMPV' named entity '3.5' named entity 'virus' named entity 'viruses' named entity 'genotypes' named entity 'A2b' named entity 'fever' named entity 'genotypes' named entity 'viruses' named entity 'China' named entity 'Changsha' named entity 'respiratory tract' named entity 'virus' named entity 'hMPV' named entity 'hMPV' named entity 'lower respiratory tract infection' named entity 'HCoV-HKU1' named entity 'hMPV' named entity 'A2a' named entity 'Hunan' named entity '5.2' named entity 'hMPV' named entity 'rhonchi' named entity 'hMPV' named entity 'fever' named entity 'nucleotide sequences' named entity 'infection' named entity 'amino acid sequences' named entity 'HRV' named entity 'Hunan Province' named entity 'infection' named entity 'human populations' named entity 'viruses' named entity 'pediatric patients' named entity 'rales' named entity 'genotype' named entity 'Paramyxoviridae' named entity 'multivariate analyses' named entity 'DNASTAR' named entity 'HCoV-NL63' named entity 'statistically significant' named entity 'epidemiological' named entity 'Nasopharyngeal' named entity 'granulocytopenia' named entity 'aspirates' named entity 'coinfection' named entity '28 days' named entity 'epidemiological' named entity 'HCoV-HKU1' named entity 'fever' named entity 'lower respiratory tract infection' named entity 'South Korea' named entity 'hMPV' named entity 'rhonchus' named entity 'lung' named entity 'genotype' named entity 'Southern China' named entity 'Promega' named entity 'PCR'

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