About: Increased serum levels of sCD14 and sCD163 indicate a preponderant role for monocytes in COVID-19 immunopathology

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About: Increased serum levels of sCD14 and sCD163 indicate a preponderant role for monocytes in COVID-19 immunopathology Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Increased serum levels of sCD14 and sCD163 indicate a preponderant role for monocytes in COVID-19 immunopathology
Creator	Martinón-Torres, Federico Luis, José José, María Isabel, Ana Javier, José Alcalde, ; Allut, García Antela López, ; Bautista, Juan Bello, ; Bernal, Del Blanco, Riveiro Carballa, Gómez Castellano, Treviño Castiñeiras, Barbeito Casuso, Regueiro Cebey López, ; Cebey-López, M Collazo, Redondo Conde, ; Cuadrado, Valdés Currás-Tuala, M Dacosta-Urbieta, De La Cruz, Navarro Devesa, ; Escudero, Álvarez Esteban, Díaz Fernández Villaverde, ; Fernández, Serén Franco, López Freixo, Pérez Fuentes, Lendoiro García, Ben García, Carral García, Rey Giráldez Vázquez, ; González Barcala, ; Guerra, ; Guirao, Aguilera Gómez-Carballa, Iglesias, Vilas Javier, Francisco Jesús, María Lago, López Lasheras, Viz Leboráns Iglesias, ; Lence Massa, ; Liñares, Beatriz Luis, María, Gloria Masid, Núñez Miguel, José Muñiz, Taboada Nieto, Coira Orayyou, Sadiki Paz, Saborido Pazo Núñez, ; Pena, Trastoy Pischedda, ; Pose Reino, ; Prada Hervella, ; Pérez, ; Rey Vázquez, ; Rial, Gómez Rivero Calle, ; Rivero-Calle, Rivero-Velasco C, Rodríguez Núñez, ; Rodríguez, Galbán Rodríguez, Piñeiro Rodríguez-Núñez N, Rodríguez-Tenreiro Sánchez, ; Romero, Portela Saito Villanueva, ; Salas, A Sanmartín, Souto Santalla, Domínguez Seco, Pardo Soledad, María Tuala, Currás Urbieta, Dacosta Varela García, ; Velasco, Rivero Verdes, Queiro Vicente, García Victoria, María
Source	MedRxiv
abstract	Background. Emerging evidence indicates a potential role for monocyte in COVID-19 immunopathology. We investigated two soluble markers of monocyte activation, sCD14 and sCD163, in covid19 patients with the aim of characterizing their potential role in monocyte-macrophage disease immunopathology. To the best of our knowledge, this is the first study of its kind. Methods. Fifty-nine SARS-Cov-2 positive hospitalized patients, classified according to ICU or non-ICU admission requirement, were prospectively recruited and analyzed by ELISA for levels of sCD14 and sCD163, along with other laboratory parameters, and compared to a healthy control group. Results. sCD14 and sCD163 levels were significantly higher among COVID-19 patients, independently of ICU admission requirement, compared to the control group. We found a significant correlation between sCD14 levels and other inflammatory markers, particularly Interleukin-6, in the non-ICU patients group. sCD163 showed a moderate positive correlation with the time at sampling from admission, increasing its value over time, independently of severity group. Conclusions. Monocyte-macrophage activation markers are increased and correlate with other inflammatory markers in SARS-Cov-2 infection, in association to hospital admission. These data suggest a potentially preponderant role for monocyte-macrophage activation in the development of immunopathology of covid19 patients.
has issue date	2020-06-04(xsd:dateTime)
bibo:doi	10.1101/2020.06.02.20120295
has license	medrxiv
sha1sum (hex)	2ed18e33f71a7afe6f7f78dd1882d6d17ba85cbc
schema:url	https://doi.org/10.1101/2020.06.02.20120295
resource representing a document's title	Increased serum levels of sCD14 and sCD163 indicate a preponderant role for monocytes in COVID-19 immunopathology
resource representing a document's body	covid:2ed18e33f71a7afe6f7f78dd1882d6d17ba85cbc#body_text

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