About: Utility of animal and in vivo experimental infection of humans with rhinoviruses in the development of therapeutic agents for viral exacerbations of asthma and chronic obstructive pulmonary disease

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About: Utility of animal and in vivo experimental infection of humans with rhinoviruses in the development of therapeutic agents for viral exacerbations of asthma and chronic obstructive pulmonary disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Utility of animal and in vivo experimental infection of humans with rhinoviruses in the development of therapeutic agents for viral exacerbations of asthma and chronic obstructive pulmonary disease
Creator	Turner, Ronald Branigan, Patrick Del Vecchio, Alfred Barnathan, Elliot Flavin, Susan Silkoff, Philip
source	Elsevier; Medline; PMC
abstract	There is an association with acute viral infection of the respiratory tract and exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Although these exacerbations are associated with several types of viruses, human rhinoviruses (HRVs) are associated with the vast majority of disease exacerbations. Due to the lack of an animal species that is naturally permissive for HRVs to use as a facile model system, and the limitations associated with animal models of asthma and COPD, studies of controlled experimental infection of humans with HRVs have been used and conducted safely for decades. This review discusses how these experimental infection studies with HRVs have provided a means of understanding the pathophysiology underlying virus-induced exacerbations of asthma and COPD with the goal of developing agents for their prevention and treatment.
has issue date	2014-11-13(xsd:dateTime)
bibo:doi	10.1016/j.pupt.2014.10.005
bibo:pmid	25445932
has license	no-cc
sha1sum (hex)	2eaa2a813ac6ff1fc901cf8eadc3b44e13d71d6a
schema:url	https://doi.org/10.1016/j.pupt.2014.10.005
resource representing a document's title	Utility of animal and in vivo experimental infection of humans with rhinoviruses in the development of therapeutic agents for viral exacerbations of asthma and chronic obstructive pulmonary disease
has PubMed Central identifier	PMC7110859
has PubMed identifier	25445932
schema:publication	Pulm Pharmacol Ther
resource representing a document's body	covid:2eaa2a813ac6ff1fc901cf8eadc3b44e13d71d6a#body_text
is schema:about of	named entity 'THERAPEUTIC AGENTS' named entity 'acute' named entity 'infection' named entity 'agents' named entity 'chronic obstructive pulmonary disease' named entity 'MAJORITY' named entity 'PREVENTION' named entity 'COPD' named entity 'HOW' named entity 'RHINOVIRUSES' named entity 'ASTHMA' named entity 'VIRUSES' named entity 'USE' named entity 'THEIR' named entity 'ANIMAL SPECIES' named entity 'CHRONIC OBSTRUCTIVE PULMONARY DISEASE' named entity 'RESPIRATORY TRACT' named entity 'DUE TO' named entity 'STUDIES' named entity 'MEANS' named entity 'REVIEW' named entity 'MODEL SYSTEM' named entity 'ANIMAL' named entity 'CHRONIC OBSTRUCTIVE PULMONARY DISEASE' named entity 'VIRAL' named entity 'ASTHMA' named entity 'IN VIVO' named entity 'DEVELOPING' named entity 'PATHOPHYSIOLOGY' named entity 'LIMITATIONS' named entity 'LACK' named entity 'THESE' named entity 'TREATMENT' named entity 'DISEASE' named entity 'VIRAL INFECTION' named entity 'ACUTE' named entity 'VIRUS' named entity 'EXPERIMENTAL INFECTION' named entity 'ASSOCIATED WITH' named entity 'DEVELOPMENT' named entity 'RHINOVIRUSES' named entity 'USED' named entity 'UNDERLYING' named entity 'HUMANS' named entity 'PROVIDED' named entity 'UNDERSTANDING' named entity 'INDUCED' named entity 'GOAL' named entity 'ANIMAL MODELS ' named entity 'HUMANS' named entity 'ASSOCIATION' named entity 'HUMAN' named entity 'UTILITY' named entity 'EXPERIMENTAL INFECTION' named entity 'CONTROLLED' named entity 'TYPES' named entity 'HAVE' named entity 'COPD' named entity 'animal' named entity 'conducted' named entity 'studies' named entity 'prevention' named entity 'infection' named entity 'asthma' named entity 'asthma' named entity 'chronic obstructive pulmonary disease' named entity 'asthma' named entity 'infection' named entity 'HRV' named entity 'pneumonia' named entity 'lung function' named entity 'proteomic' named entity 'virus' named entity 'COPD exacerbations' named entity 'infection' named entity 'infection'

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