About: Mutations, Recombination and Insertion in the Evolution of 2019-nCoV

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Mutations, Recombination and Insertion in the Evolution of 2019-nCoV
Creator	Niu, Peihua Tan, Wenjie Wang, Wenling Lu, Roujian Ye, Fei Han, Na Wu, Guizhen Jiang, Taijiao Peng, Yousong Zhao, Xiang Cheng, Genhong Zhang, Shilei Guo, Haitao Wang, Lulan Wu, Aiping Gold, Sarah Ding, Xiao Wang, Xianyue Aliyari, Saba Chen, Janet Ji, Chengyang Lenh, Emily Vikram, Ellee Wang, Jingfeng Zhou, Hangyu Zou, Angela
source	BioRxiv; MedRxiv; Medline
abstract	The 2019 novel coronavirus (2019-nCoV or SARS-CoV-2) has spread more rapidly than any other betacoronavirus including SARS-CoV and MERS-CoV. However, the mechanisms responsible for infection and molecular evolution of this virus remained unclear. We collected and analyzed 120 genomic sequences of 2019-nCoV including 11 novel genomes from patients in China. Through comprehensive analysis of the available genome sequences of 2019-nCoV strains, we have tracked multiple inheritable SNPs and determined the evolution of 2019-nCoV relative to other coronaviruses. Systematic analysis of 120 genomic sequences of 2019-nCoV revealed co-circulation of two genetic subgroups with distinct SNPs markers, which can be used to trace the 2019-nCoV spreading pathways to different regions and countries. Although 2019-nCoV, human and bat SARS-CoV share high homologous in overall genome structures, they evolved into two distinct groups with different receptor entry specificities through potential recombination in the receptor binding regions. In addition, 2019-nCoV has a unique four amino acid insertion between S1 and S2 domains of the spike protein, which created a potential furin or TMPRSS2 cleavage site. Our studies provided comprehensive insights into the evolution and spread of the 2019-nCoV. Our results provided evidence suggesting that 2019-nCoV may increase its infectivity through the receptor binding domain recombination and a cleavage site insertion. Novel 2019-nCoV sequences revealed the evolution and specificity of betacoronavirus with possible mechanisms of enhanced infectivity.
has issue date	2020-03-02(xsd:dateTime)
bibo:doi	10.1101/2020.02.29.971101
bibo:pmid	32511312
has license	medrxiv
sha1sum (hex)	2ea102f58147dab02e4dea90eb90dbc67149f678
schema:url	https://doi.org/10.1101/2020.02.29.971101
resource representing a document's title	Mutations, Recombination and Insertion in the Evolution of 2019-nCoV
has PubMed identifier	32511312
schema:publication	bioRxiv
resource representing a document's body	covid:2ea102f58147dab02e4dea90eb90dbc67149f678#body_text
is schema:about of	named entity '2019-nCoV' named entity 'coronavirus' named entity 'SARS-CoV-2' named entity 'betacoronavirus' named entity 'SARS-CoV' named entity 'Recombination' named entity 'Evolution' named entity '2019-nCoV' named entity 'Taiwan' named entity 'clade' named entity 'peer-reviewed' named entity 'doi' named entity 'clade' named entity 'doi' named entity 'peer-reviewed' named entity 'SNP' named entity 'SARS' named entity 'bioRxiv' named entity 'SARS' named entity 'bat' named entity 'maximum likelihood' named entity 'United States' named entity 'GenBank' named entity 'WHO' named entity 'preprint' named entity 'viruses' named entity 'genomes' named entity 'start and stop codons' named entity 'Nepal' named entity 'preprint' named entity 'viruses' named entity 'China' named entity 'receptor recognition' named entity 'peer-reviewed' named entity 'December 24' named entity 'evolved convergently' named entity 'SNPs' named entity 'genomes' named entity 'recombination' named entity 'furin' named entity 'nucleotide' named entity 'preprint' named entity 'preprint' named entity 'membrane fusion' named entity 'structural analysis' named entity 'upper respiratory tract' named entity 'epidemiological' named entity 'multiple sequence alignment' named entity '2019-nCoV' named entity 'preprint' named entity '2019-nCoV' named entity 'furin' named entity 'genomes' named entity 'genotype' named entity 'preprint' named entity 'peer-reviewed' named entity 'Amino acid'

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