About: Natural selection supports escape from concerted evolution of a recently duplicated CEACAM1 paralog in the ruminant CEA gene family

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Natural selection supports escape from concerted evolution of a recently duplicated CEACAM1 paralog in the ruminant CEA gene family Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Natural selection supports escape from concerted evolution of a recently duplicated CEACAM1 paralog in the ruminant CEA gene family
Creator	Kammerer, Robert Zimmermann, Wolfgang Hänske, Jana Mansfeld, Martin Friedrich, Christin Grenkowitz, Franziska Hammacher, Tim Maksimov, Pavlo Dau, Tung
Source	PMC
abstract	Concerted evolution is often observed in multigene families such as the CEA gene family. As a result, sequence similarity of paralogous genes is significantly higher than expected from their evolutionary distance. Gene conversion, a “copy paste” DNA repair mechanism that transfers sequences from one gene to another and homologous recombination are drivers of concerted evolution. Nevertheless, some gene family members escape concerted evolution and acquire sufficient sequence differences that orthologous genes can be assigned in descendant species. Reasons why some gene family members can escape while others are captured by concerted evolution are poorly understood. By analyzing the entire CEA gene family in cattle (Bos taurus) we identified a member (CEACAM32) that was created by gene duplication and cooption of a unique transmembrane domain exon in the most recent ancestor of ruminants. CEACAM32 shows a unique, testis-specific expression pattern. Phylogenetic analysis indicated that CEACAM32 is not involved in concerted evolution of CEACAM1 paralogs in ruminants. However, analysis of gene conversion events revealed that CEACAM32 is subject to gene conversion but remarkably, these events are found in the leader exon and intron sequences but not in exons coding for the Ig-like domains. These findings suggest that natural selection hinders gene conversion affecting protein sequences of the mature protein and thereby support escape of CEACAM32 from concerted evolution.
has issue date	2020-02-25(xsd:dateTime)
bibo:doi	10.1038/s41598-020-60425-4
bibo:pmid	32099040
has license	cc-by
sha1sum (hex)	2e45e30b65fd34a5727e967dda22436bffc2b57e
schema:url	https://doi.org/10.1038/s41598-020-60425-4
resource representing a document's title	Natural selection supports escape from concerted evolution of a recently duplicated CEACAM1 paralog in the ruminant CEA gene family
has PubMed Central identifier	PMC7042247
has PubMed identifier	32099040
schema:publication	Sci Rep
resource representing a document's body	covid:2e45e30b65fd34a5727e967dda22436bffc2b57e#body_text
is schema:about of	named entity 'concerted evolution' named entity 'family' named entity 'sequence similarity' named entity 'Nevertheless' named entity 'natural selection' named entity 'higher' named entity 'protein' named entity 'Ig-like domains' named entity 'gene' named entity 'paralog' named entity 'ceA' named entity 'intron' named entity 'exons' named entity 'gene' named entity 'Phylogenetic analysis' named entity 'ruminants' named entity 'CEA' named entity 'ruminant' named entity 'ruminants' named entity 'sequence similarity' named entity 'concerted evolution' named entity 'exon' named entity 'cattle' named entity 'gene conversion' named entity 'DNA repair' named entity 'gene conversion' named entity 'gene duplication' named entity 'Concerted evolution' named entity 'concerted evolution' named entity 'concerted evolution' named entity 'protein sequences' named entity 'intron sequences' named entity 'gene' named entity 'Ig-like domains' named entity 'gene family' named entity 'nucleotides' named entity 'bovine' named entity 'exons' named entity 'recombination' named entity 'natural selection' named entity 'exons' named entity 'exon' named entity 'CEACAM1' named entity 'gene family' named entity 'CEA' named entity 'Bison bison' named entity 'bovine' named entity 'exon' named entity 'ligand-binding' named entity 'mya' named entity 'agarose gel electrophoresis' named entity 'cDNA' named entity 'tRNA' named entity 'cytoplasmic domain' named entity 'CEACAM1' named entity 'CEACAM1' named entity 'gene' named entity 'wgs' named entity 'protein sequence' named entity 'ligand-binding domain' named entity 'testis' named entity 'immune receptor' named entity 'ITAM' named entity 'paralog' named entity 'adhesins' named entity 'PCR' named entity 'CEACAM16' named entity 'cDNA' named entity 'virus' named entity 'Giraffa' named entity 'phylogenetic' named entity 'bovine' named entity 'coding sequence'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software