About: An Immunopharmacoinformatics Approach in Development of Vaccine and Drug Candidates for West Nile Virus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	An Immunopharmacoinformatics Approach in Development of Vaccine and Drug Candidates for West Nile Virus
Creator	Hossain, Mohammad Khan, Sadiq, Abdul Das, Keshob Frolov, Andrej Hashem, Abu Keya, Chaman Omar, Taimur Rakib-Uz-Zaman, S Salimullah, Md Singla, Rajeev Yadav, Dharmendra
source	PMC
abstract	An outbreak of West Nile Virus (WNV) like the recent Ebola can be more epidemic and fatal to public health throughout the world. WNV possesses utmost threat as no vaccine or drug is currently available for its treatment except mosquito control. The current study applied the combined approach of immunoinformatics and pharmacoinformatics to design potential epitope-based vaccines and drug candidates against WNV. By analyzing the whole proteome of 2994 proteins, the WNV envelope glycoprotein was selected as a therapeutic target based on its highest antigenicity. After proper assessment “KSFLVHREW” and “ITPSAPSYT” were found to be the most potential T and B-cell epitopes, respectively. Besides, we have designed and validated four novel drugs from a known WNV inhibitor, AP30451 by adopting computational approaches. Toxicity assessment and drug score confirmed the effectiveness of these drug candidates. This in silico research might greatly facilitate the wet lab experiments to develop vaccine and drug against WNV.
has issue date	2018-07-06(xsd:dateTime)
bibo:doi	10.3389/fchem.2018.00246
bibo:pmid	30035107
has license	cc-by
sha1sum (hex)	2daa7e4d82eecdff82b6ea2bf5f1986b9a9fa8ef
schema:url	https://doi.org/10.3389/fchem.2018.00246
resource representing a document's title	An Immunopharmacoinformatics Approach in Development of Vaccine and Drug Candidates for West Nile Virus
has PubMed Central identifier	PMC6043868
has PubMed identifier	30035107
schema:publication	Front Chem
resource representing a document's body	covid:2daa7e4d82eecdff82b6ea2bf5f1986b9a9fa8ef#body_text
is schema:about of	named entity 'BASED' named entity 'THERAPEUTIC TARGET' named entity 'APPLIED' named entity 'ASSESSMENT' named entity 'ANALYZING' named entity 'LAB' named entity 'vaccine' named entity 'public health' named entity 'epidemic' named entity 'WNV' named entity 'West Nile Virus' named entity 'glycoprotein' named entity '5.45' named entity 'neutralizing antibodies' named entity 'bioinformatics' named entity 'malaria' named entity 'protein' named entity 'infection' named entity 'cognitive dysfunction' named entity 'epitopes' named entity 'Söding' named entity 'peptide' named entity 'epitope' named entity 'WNV' named entity 'dengue' named entity 'vaccine' named entity 'toxicity' named entity 'oral bioavailability' named entity 'permeability' named entity 'carcinogenic' named entity '3D protein structure' named entity 'West Nile virus' named entity 'MHC-I molecules' named entity 'vaccine' named entity 'ADMET' named entity 'epitopes' named entity 'MHC-I molecules' named entity 'Antigenicity' named entity 'mutation' named entity 'stereochemistry' named entity 'Cytotoxic' named entity 'epitope' named entity 'molecule' named entity 'glycoproteins' named entity 'hydrophilicity' named entity 'amino acid residues' named entity 'binding affinity' named entity 'bioinformatics' named entity 'epitope' named entity 'IC50' named entity 'WNV' named entity 'vaccine' named entity 'viral disease' named entity 'viral disease' named entity 'conformation' named entity 'irritative' named entity 'Bangladesh' named entity 'binding affinity' named entity 'Germany' named entity 'antigenic protein' named entity 'MHC' named entity '3D structure' named entity 'UniProtKB' named entity 'infection' named entity 'WNV' named entity 'PyMol' named entity 'YASARA' named entity 'infection' named entity 'allergenicity' named entity 'HLA-B'

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