About: Ethanol Extract of Sanguisorbae Radix Inhibits Mast Cell Degranulation and Suppresses 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Skin Lesions

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About: Ethanol Extract of Sanguisorbae Radix Inhibits Mast Cell Degranulation and Suppresses 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Skin Lesions Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Ethanol Extract of Sanguisorbae Radix Inhibits Mast Cell Degranulation and Suppresses 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Skin Lesions
Creator	Cho, Won-Kyung Yang, Ju-Hye Yoo, Jae-Myung Ma, Jin Yeul, Jin
Source	Medline; PMC
abstract	Sanguisorbae Radix (SR) is well known as herbal medicine named “Zi-Yu” in Korea, which is the dried roots of Sanguisorba officinalis L. (Rosacease). We investigated the underlying mechanism on the inhibition of atopic dermatitis (AD) of an ethanol extract of SR (ESR) using 2,4-dinitrochlorobenzene- (DNCB-) induced AD mice model. Oral administration of ESR significantly suppressed DNCB-induced AD-like symptoms such as scratching behavior, ear thickness, epidermal thickness, and IgE levels. To investigate the effects of ESR treatment on degranulation of IgE/Ag-activated mouse bone marrow-derived mast cells (BMMCs), we measured the release of β-hexosaminidase (β-HEX, degranulation marker). ESR decreased the infiltration of eosinophils and mast cells into the AD skin lesions. Furthermore, ESR significantly inhibited degranulation of IgE/Ag-activated BMMCs. We have demonstrated that ESR decreased AD symptoms in mice and inhibits degranulation of IgE/Ag-activated mast cells. Our study suggests that ESR may serve as a potential therapeutic candidate for the treatment of AD symptoms.
has issue date	2016-03-15(xsd:dateTime)
bibo:doi	10.1155/2016/2947390
bibo:pmid	27065570
has license	cc-by
sha1sum (hex)	2d85ecf540b138ba2c5dd735bcf986c58ede052e
schema:url	https://doi.org/10.1155/2016/2947390
resource representing a document's title	Ethanol Extract of Sanguisorbae Radix Inhibits Mast Cell Degranulation and Suppresses 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Skin Lesions
has PubMed Central identifier	PMC4811174
has PubMed identifier	27065570
schema:publication	Mediators Inflamm
resource representing a document's body	covid:2d85ecf540b138ba2c5dd735bcf986c58ede052e#body_text
is schema:about of	named entity '2C4' named entity 'ETHANOL' named entity 'dried' named entity 'demonstrated' named entity 'investigated' named entity 'SUPPRESSES' covid:arg/2d85ecf540b138ba2c5dd735bcf986c58ede052e named entity 'HEXOSAMINIDASE' named entity 'INDUCED' named entity 'KOREA' named entity 'MOUSE BONE MARROW' named entity 'MODEL' named entity 'MAST CELLS' named entity 'INVESTIGATED' named entity 'ESR' named entity 'EAR THICKNESS' named entity 'TO INVESTIGATE' named entity 'UNDERLYING' named entity 'ROOTS' named entity 'IGE LEVELS' named entity 'USING' named entity 'EOSINOPHILS' named entity 'ACTIVATED' named entity 'HAVE' named entity 'ETHANOL' named entity 'POTENTIAL' named entity 'THICKNESS' named entity 'DEGRANULATION' named entity 'SANGUISORBA OFFICINALIS L.' named entity 'EPIDERMAL' named entity 'SYMPTOMS' named entity 'IGE' named entity 'TREATMENT' named entity 'RELEASE' named entity 'DEMONSTRATED' named entity 'CANDIDATE' named entity 'RADIX' named entity '2C4' named entity 'STUDY' named entity 'SUPPRESSED' named entity 'ATOPIC DERMATITIS' named entity 'ORAL ADMINISTRATION' named entity 'LIKE' named entity 'DERIVED' named entity 'DNCB' named entity 'INDUCED' named entity 'NAMED' named entity 'LIKE' named entity 'DINITROCHLOROBENZENE' named entity 'EXTRACT' named entity 'SKIN LESIONS' named entity 'ATOPIC DERMATITIS' named entity 'MAST CELL DEGRANULATION' named entity 'RADIX' named entity 'KNOWN' named entity 'MARKER' named entity 'DRIED' named entity 'MEASURED' named entity 'ESR DECREASED' named entity 'INHIBITION' named entity 'SERVE' named entity 'INFILTRATION' named entity 'HEX' named entity 'EFFECTS' named entity 'EXTRACT' named entity 'OUR' named entity 'SCRATCHING' named entity 'BEHAVIOR' named entity 'INHIBITED' named entity 'MICE' named entity 'THERAPEUTIC' named entity 'MECHANISM' named entity 'SKIN LESIONS' named entity 'HERBAL MEDICINE' named entity 'DINITROCHLOROBENZENE' named entity 'degranulation' named entity 'IgE'

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