About: Interferon Regulatory Factor-1 Mediates Alveolar Macrophage Pyroptosis During LPS-Induced Acute Lung Injury in Mice

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About: Interferon Regulatory Factor-1 Mediates Alveolar Macrophage Pyroptosis During LPS-Induced Acute Lung Injury in Mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interferon Regulatory Factor-1 Mediates Alveolar Macrophage Pyroptosis During LPS-Induced Acute Lung Injury in Mice
Creator	Huang, Li Li, Yuanyuan Pan, Pinhua Qin, Qingwu Su, Xiaoli Tan, Hongyi Wu, Dongdong Zhang, Lemeng
Source	PMC
abstract	Previously, we demonstrated that pyroptosis in alveolar macrophages (AMs) plays an essential role in lipopolysaccharide (LPS)-induced acute lung injury. However, the underlying mechanism remains largely unclear. Here, we show that the absence of interferon regulatory factor 1 (IRF-1) in genetic knock-out mice strongly abrogates pyroptosis in AMs and alleviates the LPS-induced lung injury and systemic inflammation. Our study demonstrates that IRF-1 contributes to caspase-1 activation and apoptosis-associated speck-like protein containing a caspase activation and recruitment domain pyroptosome formation in AMs and leads to downstream inflammatory cytokine release, including that of IL-1β, IL-18, and HMGB1. The nuclear translocation of IRF-1 is linked to the presence of toll-like receptor 4 (TLR4). Our findings suggest that pyroptosis and the downstream inflammatory response in AMs induced by LPS is a process that is dependent on TLR4-mediated up-regulation of IRF-1. In summary, IRF-1 plays a key role in controlling caspase-1-dependent pyroptosis and inflammation.
has issue date	2016-08-15(xsd:dateTime)
bibo:doi	10.1097/shk.0000000000000595
bibo:pmid	26939040
has license	cc-by-nc-nd
sha1sum (hex)	2d5eaeaa1aa523394ce7697d3cbe98381a2c1559
schema:url	https://doi.org/10.1097/shk.0000000000000595
resource representing a document's title	Interferon Regulatory Factor-1 Mediates Alveolar Macrophage Pyroptosis During LPS-Induced Acute Lung Injury in Mice
has PubMed Central identifier	PMC4978602
has PubMed identifier	26939040
schema:publication	Shock
resource representing a document's body	covid:2d5eaeaa1aa523394ce7697d3cbe98381a2c1559#body_text
is schema:about of	named entity 'CASPASE-1' named entity 'ALVEOLAR MACROPHAGES' named entity 'PLAYS' named entity 'TOLL-LIKE RECEPTOR 4' named entity 'DEMONSTRATED' named entity 'STUDY' named entity 'CONTAINING' named entity 'INFLAMMATORY CYTOKINE' named entity 'CYTOKINE RELEASE' named entity 'IL-18' named entity 'LUNG INJURY' named entity 'SUGGEST' named entity 'MEDIATED' named entity 'SYSTEMIC INFLAMMATION' named entity 'INFLAMMATION' named entity 'MECHANISM' named entity 'ACUTE LUNG INJURY' named entity 'LIPOPOLYSACCHARIDE' named entity 'KEY' named entity 'IRF-1' named entity 'The' named entity 'TLR4' named entity 'cytokine' named entity 'recruitment' named entity 'AMs' named entity 'PYROPTOSIS' named entity 'INDUCED' named entity 'TLR4' named entity 'ABSENCE OF' named entity 'HMGB1' named entity 'KNOCK-OUT' named entity 'LPS' named entity 'ACTIVATION' named entity 'CASPASE ACTIVATION AND RECRUITMENT DOMAIN' named entity 'OUR' named entity 'INDUCED' named entity 'PREVIOUSLY' named entity 'APOPTOSIS' named entity 'FORMATION' named entity 'ACUTE LUNG INJURY' named entity 'INTERFERON REGULATORY FACTOR-1' named entity 'MICE' named entity 'CONTROLLING' named entity 'PYROPTOSIS' named entity 'PROTEIN ' named entity 'LEADS' named entity 'PROCESS' named entity 'IS A' named entity 'IL-1B' named entity 'PRESENCE OF' named entity 'LPS' named entity 'DOWNSTREAM' named entity 'UP-REGULATION' named entity 'MEDIATES' named entity 'ALVEOLAR MACROPHAGE' named entity 'UNCLEAR' named entity 'IRF-1' named entity 'INTERFERON REGULATORY FACTOR 1' named entity 'INFLAMMATORY RESPONSE' named entity 'INCLUDING' named entity 'HERE' named entity 'GENETIC' named entity 'ROLE' named entity 'UNDERLYING' named entity 'LARGELY' named entity 'SUMMARY' named entity 'DEPENDENT' named entity 'ESSENTIAL' named entity 'MICE' named entity 'FINDINGS' named entity 'ASSOCIATED' named entity 'AMS' named entity 'NUCLEAR TRANSLOCATION' covid:arg/2d5eaeaa1aa523394ce7697d3cbe98381a2c1559

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