About: MHC class I allele diversity in cynomolgus macaques of Vietnamese origin

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About: MHC class I allele diversity in cynomolgus macaques of Vietnamese origin Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	MHC class I allele diversity in cynomolgus macaques of Vietnamese origin
Creator	Li, Shuang Zhuo, Min Huang, Shuting Huang, Xia Zhu, Mingjun
Source	PMC
abstract	Cynomolgus macaques (Macaca fascicularis, Mafa) have been used as important experimental animal models for carrying out biomedical researches. The results of biomedical experiments strongly depend on the immunogenetic background of animals, especially on the diversity of major histocompatibility complex (MHC) alleles. However, there is much less information available on the polymorphism of MHC class I genes in cynomolgus macaques, than is currently available for humans. In this study, we have identified 40 Mafa-A and 60 Mafa-B exons 2 and 3 sequences from 30 unrelated cynomolgus macaques of Vietnamese origin. Among these alleles, 28 are novel. As for the remaining 72 known alleles, 15 alleles are shared with other cynomolgus macaque populations and 32 are identical to alleles previously reported in other macaque species. A potential recombination event was observed between Mafa-A1091:02 and Mafa-A1057:01. In addition, the Mafa-A1 genes were found to be more diverse than human HLA-A and the functional residues for peptide binding sites (PBS) or TCR binding sites (TBS) in Mafa-A1 have greater variability than that for non-PBS or non-TBS regions. Overall, this study provides important information on the diversity of Mafa-A and Mafa-B alleles from Vietnamese origin, which may help researchers to choose the most appropriate animals for their studies.
has issue date	2019-11-04(xsd:dateTime)
bibo:doi	10.7717/peerj.7941
bibo:pmid	31720104
has license	cc-by
sha1sum (hex)	2d2670b7397637426c285d293f7e5671d95e0e80
schema:url	https://doi.org/10.7717/peerj.7941
resource representing a document's title	MHC class I allele diversity in cynomolgus macaques of Vietnamese origin
has PubMed Central identifier	PMC6836755
has PubMed identifier	31720104
schema:publication	PeerJ
resource representing a document's body	covid:2d2670b7397637426c285d293f7e5671d95e0e80#body_text
is schema:about of	named entity 'CREATIVE COMMONS' named entity 'major histocompatibility complex (MHC)' named entity 'HLA-A' named entity 'ORIGIN' named entity 'MHC CLASS I ALLELE' named entity 'SHARED' named entity 'STUDY' named entity 'FUNCTIONAL' covid:arg/2d2670b7397637426c285d293f7e5671d95e0e80 named entity 'GREATER' named entity 'REGIONS' named entity 'CYNOMOLGUS' named entity 'CYNOMOLGUS MACAQUE' named entity 'MACAQUE' named entity 'MAJOR HISTOCOMPATIBILITY COMPLEX' named entity 'THESE' named entity 'ALLELES' named entity 'HAVE' named entity 'BIOMEDICAL' named entity 'PREVIOUSLY' named entity 'POLYMORPHISM' named entity 'POTENTIAL' named entity 'INFORMATION' named entity 'VIETNAMESE' named entity 'RESEARCHERS' named entity 'REPORTED' named entity 'POPULATIONS' named entity 'FOUND' named entity 'ANIMALS' named entity 'CARRYING' named entity 'ACCESS' named entity 'OPEN' named entity 'BINDING SITES' named entity 'EVENT' named entity 'PBS' named entity 'HLA-A' named entity 'IDENTICAL' named entity 'REMAINING' named entity 'CHOOSE' named entity 'IMMUNOGENETIC' named entity 'OBSERVED' named entity 'VIETNAMESE' named entity 'DIVERSITY' named entity 'MACAQUES' named entity 'AVAILABLE' named entity 'MACAQUES' named entity 'VARIABILITY' named entity 'MAFA' named entity 'ADDITION' named entity 'DIVERSITY' named entity 'SEQUENCES' named entity 'CYNOMOLGUS' named entity 'PROVIDES' named entity 'IDENTIFIED' named entity 'EXPERIMENTS' named entity 'KNOWN' named entity 'PEPTIDE BINDING' named entity 'ORIGIN' named entity 'NON-' named entity 'MHC CLASS I GENES' named entity 'MUCH' named entity 'UNRELATED' named entity 'THEIR' named entity 'HUMANS' named entity 'SPECIES' named entity 'OVERALL' named entity 'HELP' named entity 'TBS' named entity 'EXPERIMENTAL ANIMAL MODELS' named entity 'EXONS' named entity 'ANIMAL MODELS ' named entity 'RECOMBINATION' named entity 'APPROPRIATE' named entity 'STUDIES' named entity 'GENES' named entity 'TCR BINDING' named entity 'RESULTS'

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