About: ACE2 coding variants in different populations and their potential impact on SARS-CoV-2 binding affinity

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About: ACE2 coding variants in different populations and their potential impact on SARS-CoV-2 binding affinity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	ACE2 coding variants in different populations and their potential impact on SARS-CoV-2 binding affinity
Creator	Amin, Muhamed Ali, Fedaa Alkordi, Mohamed Menattallah, † Elserafy, Menattallah
source	Elsevier; Medline; PMC
abstract	The susceptibility of different populations to SARS-CoV-2 infection is not yet understood. Here, we combined ACE2 coding variants analysis in different populations and computational chemistry calculations to probe the effects on SARS-CoV-2/ACE2 interaction. ACE2-K26R; which is most frequent in Ashkenazi Jewish population decreased the SARS-CoV-2/ACE2 electrostatic attraction. On the contrary, ACE2-I468V, R219C, K341R, D206G, G211R increased the electrostatic attraction; ordered by binding strength from weakest to strongest. The aforementioned variants are most frequent in East Asian, South Asian, African and African American, European, European and South Asian populations, respectively.
has issue date	2020-08-20(xsd:dateTime)
bibo:doi	10.1016/j.bbrep.2020.100798
bibo:pmid	32844124
has license	no-cc
sha1sum (hex)	2d14cd1c13358f6a978bc8004414cd91260265f9
schema:url	https://doi.org/10.1016/j.bbrep.2020.100798
resource representing a document's title	ACE2 coding variants in different populations and their potential impact on SARS-CoV-2 binding affinity
has PubMed Central identifier	PMC7439997
has PubMed identifier	32844124
schema:publication	Biochem Biophys Rep
resource representing a document's body	covid:2d14cd1c13358f6a978bc8004414cd91260265f9#body_text
is schema:about of	named entity 'populations' named entity 'residues' named entity 'populations' named entity 'potential' named entity 'EFFECTS' named entity 'TABLE' named entity 'ACE2' named entity 'ACE2' named entity 'populations' named entity 'electrostatic' named entity 'American' named entity 'SARS-CoV-2' named entity 'residues' named entity 'probe' named entity 'electrostatic attraction' named entity 'East Asian' named entity 'SARS-CoV-2' named entity 'South Asian' named entity 'electrostatic attraction' named entity 'RBD' named entity 'ACE2' named entity 'coding Variants' named entity 'binding affinity' named entity 'SARS-CoV-2' named entity 'Ashkenazi' named entity 'SARS-CoV' named entity 'amino acids' named entity 'mutants' named entity 'protein' named entity 'dielectric constant' named entity 'host cells' named entity 'wild type' named entity 'ACE2' named entity 'electrostatic interactions' named entity 'energetically favorable' named entity 'spike protein' named entity 'dielectric constant' named entity 'ACE2' named entity 'electrostatic attraction' named entity 'SARS-CoV-2' named entity 'ACE2' named entity 'SARS-CoV-2' named entity 'binding energy' named entity 'Neutral amino acid transporter' named entity 'electrostatic attraction' named entity 'SARS-CoV-2' named entity 'ACE2' named entity 'SARS-CoV-2' named entity 'ACE2' named entity 'RBD' named entity 'SARS-CoV-2' named entity 'ACE2' named entity 'binding site' named entity 'mutants' named entity 'cerebrovascular disease' named entity 'ACE2' named entity 'PDB' named entity 'SARS-CoV-2' named entity 'electrostatic' named entity 'Kcal' named entity 'missense variants' named entity 'X-ray crystal structure' named entity 'Kcal' named entity 'infection' named entity 'van der Waals' named entity 'Kcal' named entity 'receptor' named entity '2.1' named entity 'protein' named entity 'protein' named entity 'diabetes mellitus' named entity 'SARS-CoV-2' named entity 'ACE2' named entity 'electrostatic interactions' named entity 'van der Waals' named entity 'ACE2' named entity 'ACE2'

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