About: Enteric Lesions and Diarrhea in Gnotobiotic Calves Monoinfected with Cryptosporidium Species

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Enteric Lesions and Diarrhea in Gnotobiotic Calves Monoinfected with Cryptosporidium Species
Creator	Moon, H Woode, G Heine, J Pohlenz, J
Source	PMC
abstract	The pathogenicity of Cryptosporidium species was studied by inoculation of two gnotobiotic calves with cryptosporidial oocysts that had been decontaminated by treatment with peracetic acid. Two control calves were inoculated with similar material from which the oocysts had been removed by filtration. Oocyst-inoculated animals shed Cryptosporidium in their feces and developed depression, weakness, anorexia, and diarrhea. At necropsy five days after inoculation, endogeneous stages of Cryptosporidium were found in association with epithelial cells throughout the small and large intestines of these animals. The parasites were most numerous in the lower small intestine. Atrophic villi, disordered and degenerate villous epithelium, and hyperplastic crypt epithelium were associated with infection in the small intestine. Control animals remained normal. Extraneous agents were not detected in any of the calves. The results indicate that Cryptosporidium can destroy intestinal epithelial cells and cause diarrhea in monoinfected gnotobiotic calves.
has issue date	1984-11-01(xsd:dateTime)
bibo:doi	10.1093/infdis/150.5.768
bibo:pmid	6491380
has license	no-cc
sha1sum (hex)	2cc24fdc1ec3d7bb2f46a2a0008658aff6d6b819
schema:url	https://doi.org/10.1093/infdis/150.5.768
resource representing a document's title	Enteric Lesions and Diarrhea in Gnotobiotic Calves Monoinfected with Cryptosporidium Species
has PubMed Central identifier	PMC7109781
has PubMed identifier	6491380
schema:publication	J Infect Dis
resource representing a document's body	covid:2cc24fdc1ec3d7bb2f46a2a0008658aff6d6b819#body_text
is schema:about of	named entity 'intestinal epithelial cells' named entity 'calves' named entity 'oocysts' named entity 'control' named entity 'Calves' named entity 'Lesions' named entity 'DAYS' named entity 'SMALL INTESTINE' named entity 'DESTROY' named entity 'FOUND' named entity 'INFECTION' named entity 'DEPRESSION' named entity 'DISORDERED' named entity 'FILTRATION' named entity 'FECES' named entity 'ASSOCIATION' named entity 'NUMEROUS' named entity 'PARASITES' covid:arg/2cc24fdc1ec3d7bb2f46a2a0008658aff6d6b819 named entity 'feces' named entity 'animals' named entity 'animals' named entity 'pathogenicity' named entity 'depression' named entity 'developed' named entity 'normal' named entity 'infection' named entity 'pathogenicity' named entity 'inoculation' named entity 'small intestine' named entity 'Cryptosporidium' named entity 'feces' named entity 'Gnotobiotic' named entity 'Diarrhea' named entity 'gnotobiotic' named entity 'proximal' named entity 'electron microscopic' named entity 'ileum' named entity 'centrifugation' named entity 'oocysts' named entity 'villi' named entity 'carbol fuchsin' named entity 'vacuolated' named entity 'mice' named entity 'small intestine' named entity 'inoculation' named entity 'inoculation' named entity 'rotavirus' named entity 'oocysts' named entity 'oocysts' named entity 'inorganic phosphorus' named entity 'mucus' named entity 'parasitized' named entity 'gnotobiotic' named entity 'gram stain' named entity 'pathogenicity' named entity 'ultrastructural' named entity 'epithelial cells' named entity 'peracetic acid' named entity 'depression' named entity 'feces' named entity 'feces' named entity 'enteric disease' named entity 'epithelial cells' named entity 'villous' named entity 'infection' named entity 'descending colon' named entity 'Blood samples' named entity 'lumen' named entity 'pylorus' named entity 'ileum' named entity 'viruses' named entity 'Transmission electron microscopy' named entity 'PBS' named entity 'ileocecal valve' named entity 'diarrhea' named entity 'microvilli' named entity 'mice'

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