About: Drug screening identifies gemcitabine inhibiting rotavirus through alteration of pyrimidine nucleotide synthesis pathway

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About: Drug screening identifies gemcitabine inhibiting rotavirus through alteration of pyrimidine nucleotide synthesis pathway Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Drug screening identifies gemcitabine inhibiting rotavirus through alteration of pyrimidine nucleotide synthesis pathway
Creator	Zhou, M Wang, J Wang, N Dalton, W Hakim, A Kamar, Q Pan, H Pan, M Peppelenbosch, W Research Ikram, Antiviral
Source	Elsevier; Medline; PMC
abstract	Although rotavirus infection is usually acute and self-limiting, it can cause chronic infection with severe diseases in immunocompromised patients, including organ transplantation recipients and cancer patients irrespective of pediatric or adult patients. Since no approved medication against rotavirus infection is available, this study screened a library of safe-in-man broad-spectrum antivirals. We identified gemcitabine, a widely used anti-cancer drug, as a potent inhibitor of rotavirus infection. We confirmed this effect in 2D cell cultures and 3D cultured human intestinal organoids with both laboratory-adapted rotavirus strains and five clinical isolates. Supplementation of UTP or uridine largely abolished the anti-rotavirus activity of gemcitabine, suggesting its function through inhibition of pyrimidine biosynthesis pathway. Our results support repositioning of gemcitabine for treating rotavirus infection, especially for infected cancer patients.
has issue date	2020-05-30(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2020.104823
bibo:pmid	32485209
has license	no-cc
sha1sum (hex)	2c2e8e5d394bec00c7c2393ba0e3740343f3ea08
schema:url	https://doi.org/10.1016/j.antiviral.2020.104823
resource representing a document's title	Drug screening identifies gemcitabine inhibiting rotavirus through alteration of pyrimidine nucleotide synthesis pathway
has PubMed Central identifier	PMC7261112
has PubMed identifier	32485209
schema:publication	Antiviral Res
resource representing a document's body	covid:2c2e8e5d394bec00c7c2393ba0e3740343f3ea08#body_text
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