About: Leveraging mRNAs sequences to express SARS-CoV-2 antigens in vivo

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Leveraging mRNAs sequences to express SARS-CoV-2 antigens in vivo
Creator	Dong, Yizhou Du, Shi Hou, Xucheng Li, Wenqing Yan, Jingyue Zeng, Chunxi Zhang, Chengxiang Zhao, Weiyu
Source	BioRxiv; Medline
abstract	SARS-CoV-2 has rapidly become a pandemic worldwide; therefore, an effective vaccine is urgently needed. Recently, messenger RNAs (mRNAs) have emerged as a promising platform for vaccination. Here, we systematically investigated the untranslated regions (UTRs) of mRNAs in order to enhance protein production. Through a comprehensive analysis of endogenous gene expression and de novo design of UTRs, we identified the optimal combination of 5’ and 3’ UTR, termed as NASAR, which was five to ten-fold more efficient than the tested endogenous UTRs. More importantly, NASAR mRNAs delivered by lipid-derived nanoparticles showed dramatic expression of potential SARS-CoV-2 antigens both in vitro and in vivo. These NASAR mRNAs merit further development as alternative SARS-CoV-2 vaccines.
has issue date	2020-04-05(xsd:dateTime)
bibo:doi	10.1101/2020.04.01.019877
bibo:pmid	32511313
has license	biorxiv
sha1sum (hex)	2c1618a54fa046394ebb51da37a8bd8c28095c7e
schema:url	https://doi.org/10.1101/2020.04.01.019877
resource representing a document's title	Leveraging mRNAs sequences to express SARS-CoV-2 antigens in vivo
has PubMed identifier	32511313
schema:publication	bioRxiv
resource representing a document's body	covid:2c1618a54fa046394ebb51da37a8bd8c28095c7e#body_text
is schema:about of	named entity 'optimal' named entity 'platform' named entity 'vaccination' named entity 'mRNAs' named entity 'nanoparticles' named entity 'UTRs' named entity 'mRNAs' named entity '3' UTR' named entity 'MERIT' named entity 'IDENTIFIED' named entity 'COMBINATION' named entity 'FOLD' named entity 'TESTED' named entity 'ANTIGENS' named entity 'mRNAs' named entity 'production' named entity 'More' named entity 'efficient' named entity 'alternative' named entity 'gene' named entity 'protein' named entity 'UTRs' named entity 'de novo' named entity 'vaccines' named entity 'nanoparticles' named entity 'endogenous' named entity 'lipid' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'protein production' named entity 'SinV' named entity 'mRNA' named entity 'mRNA' named entity 'antigens' named entity 'nucleotide' named entity '40S subunit' named entity 'MicroRNAs' named entity 'mRNAs' named entity 'sequence identity' named entity 'initiation complex' named entity 'abcam' named entity 'antigens' named entity '3' UTR' named entity 'start codon' named entity 'antigen' named entity '5'UTRs' named entity 'mRNA' named entity 'abcam' named entity 'mRNA' named entity '5' UTR' named entity 'antigens' named entity 'SARS-CoV-2' named entity 'positive and negative' named entity 'UTRs' named entity '3' UTR' named entity 'luciferase' named entity 'ribosome' named entity 'housekeeping gene' named entity 'nanoparticles' named entity 'NASAR' named entity 'CYBA' named entity 'mRNAs' named entity '3' UTR' named entity '5'UTRs' named entity 'April 1' named entity 'HuR' named entity 'S27a' named entity 'Fluorescence' named entity 'assay' named entity '3' UTR' named entity 'carbenicillin' named entity '5' UTRs' named entity '3' UTR' named entity 'molecule' named entity 'mRNA'

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