About: Non-degradative Role of Atg5-Atg12/Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon gamma

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Non-degradative Role of Atg5-Atg12/Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon gamma Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Non-degradative Role of Atg5-Atg12/Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon gamma
Creator	Zhang, Lei Hwang, Seungmin Diamond, Michael Shrestha, Bimmi Duan, Erning Goel, Gautam Xavier, Ramnik Dani, Adish Lopez-Otin, Carlos Bruinsma, Monique Green, Kim Maloney, Nicole Sosnovtsev, Stanislav Thackray, Larissa Virgin, Herbert
topic	covid:2bac9f0274777b7647eb51522a6ed32d12647a7a#this
Source	Elsevier; Medline; PMC
abstract	Host resistance to viral infection requires Type-I (α/β) and -II (γ) interferon (IFN) production. Another important defense mechanism is the degradative activity of macroautophagy (herein autophagy), mediated by the coordinated action of evolutionarily conserved autophagy proteins (Atg). We show that the Atg5-Atg12/Atg16L1 protein complex, whose prior known function is in autophagosome formation, is required for IFNγ-mediated host defense against murine norovirus (MNV) infection. Importantly, the direct antiviral activity of IFNγ against MNV in macrophages required Atg5-Atg12, Atg7, and Atg16L1, but not induction of autophagy, the degradative activity of lysosomal proteases, fusion of autophagosomes and lysosomes, or the Atg8 processing protein Atg4B. IFNγ, via Atg5-Atg12/Atg16L1, inhibited formation of the membranous cytoplasmic MNV replication complex, where Atg16L1 localized. Thus, the Atg5-Atg12/Atg16L1 complex performs a pivotal, nondegradative role in IFNγ-mediated antiviral defense, establishing that multicellular organisms have evolved to use portions of the autophagy pathway machinery in a cassette-like fashion for host defense.
has issue date	2012-04-01(xsd:dateTime)
bibo:doi	10.1016/j.chom.2012.03.002
bibo:pmid	22520467
has license	hybrid-oa
sha1sum (hex)	2bac9f0274777b7647eb51522a6ed32d12647a7a
schema:url	https://doi.org/10.1016/j.chom.2012.03.002
resource representing a document's title	Non-degradative Role of Atg5-Atg12/Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon gamma
has PubMed Central identifier	PMC3348177
has PubMed identifier	22520467
schema:publication	Cell Host & Microbe
resource representing a document's body	covid:2bac9f0274777b7647eb51522a6ed32d12647a7a#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/2bac9f0274777b7647eb51522a6ed32d12647a7a
is schema:about of	named entity 'INTERFERON GAMMA' named entity 'Atg5' named entity 'Atg16L1' named entity 'MICROBE' named entity 'ATG16L1' named entity 'THE JACKSON LABORATORY' named entity 'CRE RECOMBINASE' named entity 'ANTIVIRAL ACTIVITY' named entity 'ROLE' named entity 'USED' named entity 'PURCHASED' named entity 'LYSOZYME' named entity 'MIXED' named entity 'LOCUS' named entity '129' named entity 'CELL' named entity 'ATG12' named entity 'CONSISTENT' named entity 'DIFFERENT' named entity 'C57BL' named entity 'INFORMATION' named entity 'HOST' named entity 'PROTEIN COMPLEX' named entity 'OBSERVED' named entity 'PHENOTYPES' named entity 'ATG5' named entity 'SUPPLEMENTAL' named entity 'ATG5' named entity 'AUTOPHAGY' named entity 'FIGURES' named entity 'STUDY' named entity 'MICE' named entity 'mice' named entity 'mice' named entity 'Antiviral' named entity 'Cre recombinase' named entity 'phenotypes' named entity 'mice' named entity 'Atg16L1' named entity 'Autophagy' named entity 'Astigmatism' named entity 'ATP' named entity 'anti-FLAG' named entity 'Atg5' named entity 'glycolysis' named entity 'loading control' named entity 'MEF' named entity 'serum' named entity 'autophagy' named entity 'vector' named entity 'Atg16L1' named entity 'RNase protection assay' named entity 'IgG' named entity 'western blot' named entity 'SEM' named entity 'macrophages' named entity 'western blot' named entity 'Switzerland' named entity 'western blot' named entity 'Cycloheximide' named entity 'loading control' named entity 'transfected' named entity 'ATP' named entity 'epifluorescence' named entity 'cycloheximide'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software