About: A follow-up study of children infected with SARS-CoV-2 from Western China

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About: A follow-up study of children infected with SARS-CoV-2 from Western China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A follow-up study of children infected with SARS-CoV-2 from Western China
Creator	Wang, Yi Li, Yi Wu, Jianguo Liu, Enmei Wong, Gary Xie, Jun Yang, Shu Chen, Yanni Zhou, Qi Li, Qiu Li, Weiguo Tang, Yuyi Smyth, Rosalind Yan, Xiaofeng Luo, Xu, Hongmei Zhao, Yao Meng, Wenbo Cui, Yuxia Deng, Hongli Deng, Quanmin Estill, Janne Fang, Xiuling He, Ronghui Li, Feiyu Li, Peibo Long, Xiaoru Mo, Yunbo Qin, Hong Ren, Chongsong Tang, Zhengzhen Tian, Wenguang Tian, Yong Wang, Zijun Wang, Aiguo Xiao, Hongzhou Zang, Na Zhao, Ruiqiu Zhengxiu, Zhou, Xiaqia Zhu, Jing
Source	MedRxiv
abstract	Background: To clarify the characteristic and the duration of positive nucleic acid in children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including asymptomatic children. Methods: A total of 32 children confirmed with SARS-CoV-2 infection between January 24 and February 12, 2020 from four provinces in Western China were enrolled in this study and followed up until discharge and quarantine 14 days later. Results: Eleven children (34%) were asymptomatic, among whom six children had normal computed tomographic (CT) scan images. Age and gender were not associated with clinical symptoms or the results of CT scan in children infected with SARS-CoV-2. The concentrations of white blood cells and neutrophils were higher in children with asymptomatic infection than in children with clinical symptoms or CT abnormalities. Patients who presented with CT abnormalities had lower D-dimer or lower total bilirubin than those who had normal CT scan but clinical symptoms. All children recovered and no one died or was admitted to the pediatric intensive care unit (PICU). The mean duration of positive SARS-CoV-2 nucleic acid was 15.4 (SD=7.2) days and similar for both asymptomatic children and children with symptoms or CT abnormalities. We found a significant negative correlation between the lymphocyte count and the duration of positive nucleic acid test. Conclusions: Children with asymptomatic infection should be quarantined for the same duration as symptomatic patients infected with SARS-CoV-2. The clinical significance and mechanism behind the negative correlation between the number of lymphocytes and the duration of positive SARS-CoV-2 needs further study.
has issue date	2020-04-24(xsd:dateTime)
bibo:doi	10.1101/2020.04.20.20073288
has license	medrxiv
sha1sum (hex)	2ba171d33eb8a3a98be5a36eee030f53cd612d3d
schema:url	https://doi.org/10.1101/2020.04.20.20073288
resource representing a document's title	A follow-up study of children infected with SARS-CoV-2 from Western China
resource representing a document's body	covid:2ba171d33eb8a3a98be5a36eee030f53cd612d3d#body_text
is schema:about of	named entity 'mechanism' named entity 'infected' named entity 'patients' named entity 'infected' named entity 'ASYMPTOMATIC INFECTION' named entity 'The' named entity 'lymphocytes' named entity 'negative correlation' named entity 'asymptomatic infection' named entity 'oxygen saturation' named entity 'follow-up' named entity 'mortality rate' named entity 'asymptomatic infection' named entity 'preprint' named entity 'infection' named entity 'CT scan' named entity 'clinical symptoms' named entity 'coagulation' named entity 'preprint' named entity 'medRxiv' named entity 'preprint' named entity 'leucocyte' named entity 'SARS-CoV-2' named entity 'albumin' named entity 'D-dimer' named entity 'D-dimer' named entity 'lymphocytes' named entity 'correlation' named entity 'ICU' named entity 'co-infection' named entity 'clinical symptoms' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'interferon' named entity 'medRxiv' named entity 'preprint' named entity 'preprint' named entity 'coronavirus' named entity 'Lymphocytes' named entity 'intestinal atresia' named entity 'clinical symptoms' named entity 'SARS-CoV-2' named entity 'Pearson correlation' named entity 'significant difference' named entity 'increased respiratory rate'

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