About: Lack of Innate Interferon Responses during SARS Coronavirus Infection in a Vaccination and Reinfection Ferret Model

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Lack of Innate Interferon Responses during SARS Coronavirus Infection in a Vaccination and Reinfection Ferret Model
Creator	Thiel, Volker Danesh, Ali Xu, Luoling Anderson, Austin Chu, Yong-Kyu Fang, Yuan Kistner, Otfried Lauchart, Manfred Li, Qianjun Ran, Longsi Rowe, Thomas Fomukong, Ndingsa Leon, Alberto Cameron, Cheryl Kelvin, David Cameron, Mark Jonsson, Colleen Gallen, St Harrod, Kevin Hospital, Kantonal Kelvin, Alyson Couch, Ronald Paquette, Stephane
Source	Medline; PMC
abstract	In terms of its highly pathogenic nature, there remains a significant need to further define the immune pathology of SARS-coronavirus (SARS-CoV) infection, as well as identify correlates of immunity to help develop vaccines for severe coronaviral infections. Here we use a SARS-CoV infection-reinfection ferret model and a functional genomics approach to gain insight into SARS immunopathogenesis and to identify correlates of immune protection during SARS-CoV-challenge in ferrets previously infected with SARS-CoV or immunized with a SARS virus vaccine. We identified gene expression signatures in the lungs of ferrets associated with primary immune responses to SARS-CoV infection and in ferrets that received an identical second inoculum. Acute SARS-CoV infection prompted coordinated innate immune responses that were dominated by antiviral IFN response gene (IRG) expression. Reinfected ferrets, however, lacked the integrated expression of IRGs that was prevalent during acute infection. The expression of specific IRGs was also absent upon challenge in ferrets immunized with an inactivated, Al(OH)(3)-adjuvanted whole virus SARS vaccine candidate that protected them against SARS-CoV infection in the lungs. Lack of IFN-mediated immune enhancement in infected ferrets that were previously inoculated with, or vaccinated against, SARS-CoV revealed 9 IRG correlates of protective immunity. This data provides insight into the molecular pathogenesis of SARS-CoV and SARS-like-CoV infections and is an important resource for the development of CoV antiviral therapeutics and vaccines.
has issue date	2012-09-24(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0045842
bibo:pmid	23029269
has license	cc-by
sha1sum (hex)	2b91f521c12a736203029e85675120740c3c1810
schema:url	https://doi.org/10.1371/journal.pone.0045842
resource representing a document's title	Lack of Innate Interferon Responses during SARS Coronavirus Infection in a Vaccination and Reinfection Ferret Model
has PubMed Central identifier	PMC3454321
has PubMed identifier	23029269
schema:publication	PLoS One
resource representing a document's body	covid:2b91f521c12a736203029e85675120740c3c1810#body_text
is schema:about of	named entity 'infection' named entity 'Here' named entity 'infections' named entity 'insight' named entity 'insight' named entity 'Responses' named entity 'Citation' named entity 'SARS-CoV' named entity 'Kelvin' named entity 'Ferret' named entity 'Lack' named entity 'Responses' named entity 'SIGNATURES' named entity 'TO IDENTIFY' named entity 'MODEL' named entity 'ENHANCEMENT' named entity 'VACCINATION' named entity 'REINFECTED' named entity 'IMMUNIZED' named entity 'IMPORTANT' named entity 'MEDIATED' named entity 'IDENTIFIED' named entity 'IDENTIFY' named entity 'THERAPEUTICS' named entity 'VACCINATED' named entity 'CHALLENGE' named entity 'ANTIVIRAL' named entity 'FERRET' named entity 'SARS CORONAVIRUS' named entity 'SIGNIFICANT' named entity 'MOLECULAR' named entity 'RESPONSES' named entity 'ITS' named entity 'PROTECTIVE IMMUNITY' named entity 'CITATION' named entity 'PROVIDES' named entity 'REINFECTION' named entity 'INSIGHT' named entity 'IMMUNITY' named entity 'RAN' named entity 'LACK' named entity 'FERRET' named entity 'CORONAVIRUS INFECTION' named entity 'VACCINATION' named entity 'INTERFERON ' named entity 'INFECTIONS' named entity 'IDENTICAL' named entity 'IMMUNE RESPONSES' named entity 'PRIMARY' named entity 'NEED' named entity 'VACCINES' named entity 'INTEGRATED' named entity 'COORDINATED' named entity 'LEON' named entity 'IFN' named entity 'GAIN' named entity 'HIGHLY' named entity 'PREVALENT' named entity 'INFECTION'

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