About: COVID-19: Clinical course and outcomes of 36 maintenance hemodialysis patients from a single center in Spain.

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About: COVID-19: Clinical course and outcomes of 36 maintenance hemodialysis patients from a single center in Spain. Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	COVID-19: Clinical course and outcomes of 36 maintenance hemodialysis patients from a single center in Spain.
Creator	María, Ana Alberto, Luis Luisa, Maria Abad, Soraya Anaya, Fernando Ap, José Aragoncillo, Inés Arroyo, David Barbieri, Diego Barraca, Daniel Bascuñana, Arturo Benitez, Rodriguez Carbayo, Javier Cámara, Sánchez De José, Pérez Delgado, Andrés Delgado, Felipe Ferrero, Rodriguez Goicoechea, Marian Luño, José Macías, Nicolás Melero, Rosa Mijaylova, Antonia Muñoz De Morales, Alejandra Prieto, García Pérez De José, Ana Rengel, Manuel Rodriguez Benitez, Patrocinio Rojas, González Rojas, Ángela Tejedor, Alberto Vega, Almudena Verdalles, Ursula Verde, Eduardo
Source	Elsevier; Medline; PMC
abstract	SARS-CoV-2-pneumonia emerged in Wuhan, China in December 2019. Unfortunately, there is lack of evidence about the optimal management of novel coronavirus disease 2019 (COVID-19), even less in patients on maintenance hemodialysis (MHD) therapy than in the general population. In this retrospective observational single-center study we analyzed the clinical course and outcomes of all MHD patients hospitalized with COVID-19 from March 12(th) to April 10(th), 2020 as confirmed by real time polymerase chain reaction. Baseline features, clinical course, laboratory data, and different therapies were compared between survivors and non-survivors to identify risk factors associated with mortality. Among the 36 patients, 11 (30.5%) died and 7 could be discharged within the observation period. Clinical and radiological evolution during the first week of admission were predictive of mortality. Among the 36 patients, 18 had worsening of their clinical status, as defined by severe hypoxia with oxygen therapy requirements greater than 4 Liters/minute and radiological worsening. Significantly 11 out of those 18 patients (61.1%) died. None of the classical cardiovascular risk factors in the general population were associated with higher mortality. However, a longer time on hemodialysis (hazard ratio 1.008(95% confidence interval 1.001-1.015) per year), increased LDH levels (1.006(1.001-1.011), and lower lymphocyte count (0.996 (0.992-1.000) one week after clinical onset were all significantly associated with higher mortality risk. Thus, the mortality among hospitalized hemodialysis patients diagnosed with COVID-19 is high. Lymphopenia and increased LDH levels were associated with poor prognosis.
has issue date	2020-05-11(xsd:dateTime)
bibo:doi	10.1016/j.kint.2020.04.031
bibo:pmid	32437770
has license	no-cc
sha1sum (hex)	2b64cf2cdb8e3552b24b71341507a45af7442629
schema:url	https://doi.org/10.1016/j.kint.2020.04.031
resource representing a document's title	COVID-19: Clinical course and outcomes of 36 maintenance hemodialysis patients from a single center in Spain.
has PubMed Central identifier	PMC7211728
has PubMed identifier	32437770
schema:publication	Kidney Int
resource representing a document's body	covid:2b64cf2cdb8e3552b24b71341507a45af7442629#body_text
is schema:about of	named entity 'Clinical' named entity 'Spain' named entity 'MORTALITY' named entity 'COVID-19' named entity 'hemodialysis' named entity 'Spain' named entity 'hemodialysis' named entity 'single center' named entity 'Italian' named entity 'reverse transcriptase PCR' named entity 'LDH' named entity 'x-ray' named entity 'mortality rates' named entity 'methylprednisolone' named entity 'liver function tests' named entity 'clinical experience' named entity 'creatine kinase' named entity 'nasal cannula' named entity 'rRT-PCR' named entity 'interferon β' named entity 'nosocomial' named entity 'dialysis' named entity 'virus' named entity 'Lymphopenia' named entity 'albumin' named entity 'hemodialysis' named entity 'dialysis' named entity 'biochemistry' named entity 'case series' named entity 'oxygen therapy' named entity 'Bad Homburg' named entity 'clinical features' named entity 'comorbidities' named entity 'Brescia' named entity 'fever' named entity 'COVID-19' named entity 'observational study' named entity 'risk factors' named entity 'SARS-CoV-2' named entity 'coronary heart disease' named entity 'COVID' named entity 'P-value' named entity 'general population' named entity 'dialysis' named entity 'lopinavir/ritonavir' named entity 'SARS-CoV-2' named entity 'Dialysis' named entity 'lopinavir/ritonavir'

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