About: IL-33 and ST2 as predictors of disease severity in children with viral acute lower respiratory infection

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About: IL-33 and ST2 as predictors of disease severity in children with viral acute lower respiratory infection Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	IL-33 and ST2 as predictors of disease severity in children with viral acute lower respiratory infection
Creator	Aragon, Davi Augusta, Carolina Carlotti, Panzeri Castro, Araújo Cristina, Mirela De Jesus, Santos De Queiroz Cunha, Fernando De Souza Cardoso, Ricardo De, Ítalo Farias, Carlos Filho, Alves Gagliardi, Bianca Laís, Bruna Martins, Ronaldo Neto, Arruda Paula De Carvalho, Ana Portugal, Arantes Prates, Moreira Vinícius Gomes Da Silva, Marcus
Source	Elsevier; Medline; PMC
abstract	Abstract Background Mechanisms influencing severity of acute lower respiratory infection (ALRI) in children are not established. We aimed to assess the role of inflammatory markers and respiratory viruses in ALRI severity. Methods Concentrations of interleukin(IL)-33, soluble suppression of tumorigenicity (sST)2, IL-1ß, tumor necrosis factor α, IL-4, IL-6 and IL- 8 and types of respiratory viruses were evaluated in children at the first and fifth days after hospital admission. Disease severity was defined as need for mechanical ventilation. Results Seventy-nine children <5 years-old were included; 33(41.8%) received mechanical ventilation. No associations between virus type, viral load or co-detections and severity of disease were observed. Detection of IL-33 and sST2 in nasopharyngeal aspirates (NPA) on admission were associated with higher risk for mechanical ventilation (RR = 2.89 and RR = 4.57, respectively). IL-6 and IL-8 concentrations were higher on Day 5 in mechanically ventilated children. IL-6 NPA concentrations decreased from Day 1 to Day 5 in children who did not receive mechanical ventilation. Increase in sST2 NPA concentrations from Day 1 to Day 5 was associated with longer hospital length of stay (p < 0.01). Conclusions An exacerbated local activation of the IL-33/ST2 axis and persistently high sST2 concentrations over time were associated with severity of viral ALRI in children.
has issue date	2020-03-31(xsd:dateTime)
bibo:doi	10.1016/j.cyto.2019.154965
bibo:pmid	31901762
has license	els-covid
sha1sum (hex)	2b4dbef3d273875c9848230f006161208a5cf139
schema:url	https://doi.org/10.1016/j.cyto.2019.154965
resource representing a document's title	IL-33 and ST2 as predictors of disease severity in children with viral acute lower respiratory infection
has PubMed Central identifier	PMC7129023
has PubMed identifier	31901762
schema:publication	Cytokine
resource representing a document's body	covid:2b4dbef3d273875c9848230f006161208a5cf139#body_text
is schema:about of	named entity 'viral load' named entity 'time' named entity 'high' named entity 'mechanical ventilation' named entity 'IL-33' named entity 'IL-33' named entity 'IL-33' named entity 'RESPIRATORY VIRUSES' named entity 'TIME' named entity 'DISEASE' named entity 'DECREASED' named entity 'TUMOR NECROSIS FACTOR ' named entity 'ACTIVATION' named entity 'DAY 1' named entity 'SOLUBLE' named entity 'ASSOCIATED WITH' named entity '0.01' named entity 'NPA' named entity 'OBSERVED' named entity 'DEFINED' named entity 'DAY 5' named entity 'HIGH' named entity 'SEVENTY-NINE' named entity '292' named entity 'MECHANISMS' named entity 'CONCENTRATIONS' named entity 'DID' named entity 'FIFTH' named entity 'SUPPRESSION' named entity 'ACUTE' named entity 'VIRAL' named entity 'ST2' named entity 'PERSISTENTLY' covid:arg/2b4dbef3d273875c9848230f006161208a5cf139 named entity 'CHILDREN' named entity 'INTERLEUKIN' named entity 'EVALUATED' named entity 'ACUTE' named entity 'LOWER RESPIRATORY INFECTION' named entity 'TUMORIGENICITY' named entity 'VIRAL' named entity 'NASOPHARYNGEAL' named entity 'VIRAL LOAD' named entity 'IL-1' named entity 'DISEASE SEVERITY' named entity 'INCREASE' named entity 'DETECTION' named entity 'RESULTS' named entity 'LOCAL' named entity 'ASPIRATES' named entity 'ESTABLISHED' named entity 'SST2' named entity 'AXIS' named entity 'INCLUDED' named entity 'DISEASE SEVERITY' named entity '28P' named entity 'MECHANICAL VENTILATION' named entity 'LOWER RESPIRATORY INFECTION' named entity 'RISK' named entity 'ROLE' named entity 'METHODS' named entity 'IL-6' named entity 'IL-8'

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