About: A novel Chimpanzee serotype-based adenoviral vector as delivery tool for cancer vaccines

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About: A novel Chimpanzee serotype-based adenoviral vector as delivery tool for cancer vaccines Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A novel Chimpanzee serotype-based adenoviral vector as delivery tool for cancer vaccines
Creator	Aurisicchio, Luigi Ciliberto, Gennaro Cortese, Riccardo Cirillo, Agostino Colloca, Stefano Dharmapuri, Sridhar Nicosia, Alfredo Peruzzi, Daniela Monica, Nicola Bruni, Bruno
Source	Elsevier; Medline; PMC
abstract	Abstract The use of adenovirus (Ad) as vaccine vectors is hindered by pre-existing immunity to human Ads in most of the human population. In order to overcome this limitation, uncommon alternative Ad serotypes need to be utilized. In this study, an E1–E3 deleted recombinant Ad based on the chimpanzee serotype 3 (ChAd3) was engineered to express human carcinoembryonic antigen (CEA) protein or rat neu extracellular/transmembrane domains (ECD.TM). ChAd3 vectors were tested in CEA transgenic (CEA.Tg) and BALB/NeuT mice, which show immunologic tolerance to these antigens. ChAd3 is capable of inducing an immune response comparable to that of hAd5 serotype-based vectors, thus breaking tolerance to tumor associated antigens (TAAs) and achieving anti-tumor effects. Of importance is that ChAd3 can overcome hAd5 pre-existing immunity and work in conjunction with DNA electroporation (DNA-EP) and other Ad vaccines based on common human serotypes.
has issue date	2009-02-25(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2008.12.051
bibo:pmid	19162112
has license	els-covid
sha1sum (hex)	2b3e73ad2f395eba2016663de34d90751be15038
schema:url	https://doi.org/10.1016/j.vaccine.2008.12.051
resource representing a document's title	A novel Chimpanzee serotype-based adenoviral vector as delivery tool for cancer vaccines
has PubMed Central identifier	PMC7115565
has PubMed identifier	19162112
schema:publication	Vaccine
resource representing a document's body	covid:2b3e73ad2f395eba2016663de34d90751be15038#body_text
is schema:about of	named entity 'vectors' named entity 'based' named entity 'tool' named entity 'DELIVERY' named entity 'BASED' named entity 'ADENOVIRAL VECTOR' named entity 'TOLERANCE' named entity 'MOST OF' named entity 'OVERCOME' named entity 'SEROTYPE' named entity 'EFFECTS' named entity 'CONJUNCTION' named entity 'IMMUNOLOGIC TOLERANCE' named entity 'SEROTYPES' named entity 'TUMOR' named entity 'IMMUNITY' named entity 'VACCINES' named entity 'INDUCING' named entity 'HUMAN' named entity 'CARCINOEMBRYONIC ANTIGEN' named entity 'ANTIGENS' named entity 'TOOL' named entity 'THESE' named entity 'RECOMBINANT' named entity 'HUMAN POPULATION' named entity 'NOVEL' named entity 'CHIMPANZEE' named entity 'CANCER VACCINES' named entity 'TO EXPRESS' named entity 'ELECTROPORATION' named entity 'COMMON' named entity 'BALB' named entity 'VACCINE' named entity 'TESTED' named entity 'NEU' named entity 'ENGINEERED' named entity 'ORDER' named entity 'WORK IN' named entity 'ASSOCIATED' named entity 'ALTERNATIVE' named entity 'PRE-EXISTING' named entity 'DELETED' named entity 'STUDY' named entity 'EXTRACELLULAR' named entity 'MICE' named entity 'ADENOVIRUS' named entity 'UNCOMMON' named entity 'ADS' named entity 'NEED' named entity 'LIMITATION' named entity 'IMMUNE RESPONSE' named entity 'DNA' named entity 'CEA' named entity 'CAPABLE' named entity 'PROTEIN ' named entity 'SEROTYPE' named entity 'RAT' named entity 'USE OF' named entity 'BASED' named entity 'BREAKING' named entity 'TRANSGENIC' named entity 'CHIMPANZEE' named entity 'VECTORS' covid:arg/2b3e73ad2f395eba2016663de34d90751be15038 named entity 'vaccines' named entity 'breaking' named entity 'extracellular' named entity 'limitation' named entity 'immune response' named entity 'recombinant' named entity 'adenovirus' named entity 'rat'

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