About: Metal–Peptide Complexes as Promising Antibiotics to Fight Emerging Drug Resistance: New Perspectives in Tuberculosis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Metal–Peptide Complexes as Promising Antibiotics to Fight Emerging Drug Resistance: New Perspectives in Tuberculosis
Creator	De Benedictis, Arianna De Benedictis, Ilaria Marasco, Daniela Natale, Concetta
Source	Medline; PMC
abstract	In metal-peptide interactions, cations form stable complexes through bonds with coordinating groups as side chains of amino acids. These compounds, among other things, exert a wide variety of antimicrobial activities through structural changes of peptides upon metal binding and redox chemistry. They exhibit different mechanisms of action (MOA), including the modification of DNA/RNA, protein and cell wall synthesis, permeabilization and modulation of gradients of cellular membranes. Nowadays, the large increase in antibiotic resistance represents a crucial problem to limit progression at the pandemic level of the diseases that seemed nearly eradicated, such as tuberculosis (Tb). Mycobacterium tuberculosis (Mtb) is intrinsically resistant to many antibiotics due to chromosomal mutations which can lead to the onset of novel strains. Consequently, the maximum pharmaceutical effort should be focused on the development of new therapeutic agents and antimicrobial peptides can represent a valuable option as a copious source of potential bioactive compounds. The introduction of a metal center can improve chemical diversity and hence specificity and bioavailability while, in turn, the coordination to peptides of metal complexes can protect them and enhance their poor water solubility and air stability: the optimization of these parameters is strictly required for drug prioritization and to obtain potent inhibitors of Mtb infections with novel MOAs. Here, we present a panoramic review of the most recent findings in the field of metal complex-peptide conjugates and their delivery systems with the potential pharmaceutical application as novel antibiotics in Mtb infections.
has issue date	2020-06-18(xsd:dateTime)
bibo:doi	10.3390/antibiotics9060337
bibo:pmid	32570779
has license	cc-by
sha1sum (hex)	2b258739934ab326a6e9636e1c7b5cfd8cba178b
schema:url	https://doi.org/10.3390/antibiotics9060337
resource representing a document's title	Metal–Peptide Complexes as Promising Antibiotics to Fight Emerging Drug Resistance: New Perspectives in Tuberculosis
has PubMed Central identifier	PMC7344629
has PubMed identifier	32570779
schema:publication	Antibiotics (Basel)
resource representing a document's body	covid:2b258739934ab326a6e9636e1c7b5cfd8cba178b#body_text
is schema:about of	named entity 'cell wall' named entity 'metal' named entity 'Mycobacterium tuberculosis' named entity 'coordination' named entity 'RNA' named entity 'diseases' named entity 'problem' named entity 'Drug' named entity 'antibiotics' named entity 'REQUIRED' named entity 'NEARLY' named entity 'MTB' named entity 'STABILITY' named entity 'WATER SOLUBILITY' named entity 'LEAD' named entity 'MYCOBACTERIUM TUBERCULOSIS' named entity 'MAXIMUM' named entity 'THERAPEUTIC AGENTS' named entity 'ACTION' named entity 'PARAMETERS' covid:arg/2b258739934ab326a6e9636e1c7b5cfd8cba178b named entity 'groups' named entity 'development' named entity 'tuberculosis' named entity 'interactions' named entity 'therapeutic' named entity 'compounds' named entity 'activities' named entity 'specificity' named entity 'action' named entity 'conjugates' named entity 'coordinating' named entity 'potent' named entity 'Mtb' named entity 'structural' named entity 'large' named entity 'agents' named entity 'Emerging' named entity 'metal complex' named entity 'peptide' named entity 'delivery systems' named entity 'cations' named entity 'water solubility' named entity 'bioavailability' named entity 'antibiotics' named entity 'cell wall' named entity 'tuberculosis' named entity 'Peptide' named entity 'mortality rate' named entity 'kanamycin' named entity 'antimicrobial activity' named entity 'ligands' named entity 'ligand' named entity 'cathelicidin' named entity 'ofloxacin' named entity 'nucleic acids' named entity 'plasmid' named entity 'ruthenium' named entity 'mycobacterial' named entity '1,2,3-triazole' named entity 'macrocycle' named entity 'peptide' named entity 'bacitracin' named entity 'immune response' named entity 'cyclic peptide' named entity 'oxidized metal' named entity 'peptide-based' named entity 'magnetite' named entity 'antibiotic' named entity 'alkyl' named entity 'hyaluronate' named entity 'β-hairpin' named entity 'antimicrobial activities' named entity 'capreomycin' named entity 'benzothiazole' named entity 'catalyzes' named entity 'antimicrobial activities' named entity 'Enterococcus'

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