About: Inflammatory responses relate to distinct bronchoalveolar lavage lipidome in community-acquired pneumonia patients: a pilot study

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About: Inflammatory responses relate to distinct bronchoalveolar lavage lipidome in community-acquired pneumonia patients: a pilot study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Inflammatory responses relate to distinct bronchoalveolar lavage lipidome in community-acquired pneumonia patients: a pilot study
Creator	Gao, Zhancheng Zheng, Yali Kang, Yu Liu, Xiaohui Chen, Yusheng Yu, Xu He, Yukun Wang, Xiaorong Luo, Qiongzhen Ning, Pu
Source	PMC
abstract	BACKGROUND: Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality worldwide. Antibiotics are losing their effectiveness due to the emerging infectious diseases, the scarcity of novel antibiotics, and the contributions of antibiotic misuse and overuse to resistance. Characterization of the lipidomic response to pneumonia and exploring the “lipidomic phenotype” can provide new insight into the underlying mechanisms of pathogenesis and potential avenues for diagnostic and therapeutic treatments. METHODS: Lipid profiles of bronchoalveolar lavage fluid (BALF) samples were generated through untargeted lipidomic profiling analysis using high-performance liquid chromatography with mass spectrometry (HPLC-MS). Principal component analysis (PCA) was applied to identify possible sources of variations among samples. Partitioning clustering analysis (k-means) was employed to evaluate the existence of distinct lipidomic clusters. RESULTS: PCA showed that BALF lipidomes differed significantly between CAP (n = 52) and controls (n = 68, including 35 healthy volunteers and 33 patients with non-infectious lung diseases); while no clear separation was found between severe CAP and non-severe CAP cases. Lactosylceramides were the most prominently elevated lipid constituent in CAP. Clustering analysis revealed three separate lipid profiles; subjects in each cluster exhibited significant differences in disease severity, incidence of hypoxemia, percentages of phagocytes in BALF, and serum concentrations of albumin and total cholesterol (all p < 0.05). In addition, SM (d34:1) was negatively related to macrophage (adjusted r = − 0.462, p < 0.0001) and PE (18:1p/20:4) was positively correlated with polymorphonuclear neutrophil (PMN) percentages of BALF (adjusted r = 0.541, p < 0.0001). The 30-day mortality did not differ amongst three clusters (p < 0.05). CONCLUSIONS: Our data suggest that specific lower airway lipid composition is related to different intensities of host inflammatory responses, and may contribute to functionally relevant shifts in disease pathogenesis in CAP individuals. These findings argue for the need to tailor therapy based on specific lipid profiles and related inflammatory status. TRIAL REGISTRATION: ClinicalTrials.gov (NCT03093220). Registered on 28 March 2017 (retrospectively registered). ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12931-019-1028-8) contains supplementary material, which is available to authorized users.
has issue date	2019-05-02(xsd:dateTime)
bibo:doi	10.1186/s12931-019-1028-8
bibo:pmid	31046764
has license	cc-by
sha1sum (hex)	2b2545063319410829de75a23e0194e50244692c
schema:url	https://doi.org/10.1186/s12931-019-1028-8
resource representing a document's title	Inflammatory responses relate to distinct bronchoalveolar lavage lipidome in community-acquired pneumonia patients: a pilot study
has PubMed Central identifier	PMC6498485
has PubMed identifier	31046764
schema:publication	Respir Res
resource representing a document's body	covid:2b2545063319410829de75a23e0194e50244692c#body_text
is schema:about of	covid:arg/2b2545063319410829de75a23e0194e50244692c named entity 'insight' named entity 'resistance' named entity 'morbidity' named entity 'pathogenesis' named entity 'responses' named entity 'therapeutic treatments' named entity 'phenotype' named entity 'Community-acquired pneumonia' named entity 'emerging infectious diseases' named entity 'pathogenesis' named entity 'morbidity' named entity 'bronchoalveolar lavage' named entity 'Inflammatory responses' named entity 'inflammatory response' named entity 'PMNs' named entity 'cell adhesion' named entity 'APACHE' named entity 'BALF' named entity 'phospholipids' named entity 'non-polar' named entity 'pneumonia' named entity 'pro-inflammatory' named entity 'BALF' named entity 'BALF' named entity 'PSI' named entity 'lipids' named entity 'categorical data' named entity 'BALF' named entity 'assay' named entity 'HPLC-MS' named entity 'negative ion' named entity 'lipids' named entity 'Bronchoscopy' named entity 'lipoprotein' named entity 'lipids' named entity 'etiological' named entity 'SCAP' named entity 'lipid' named entity 'PUFA' named entity 'BALF' named entity '14.1' named entity 'lipid' named entity 'pro-inflammatory' named entity 'neutrophils' named entity 'SPSS' named entity 'inflammation' named entity 'infection' named entity 'lipid' named entity 'BALF' named entity 'BALF' named entity 'fatty acids' named entity 'eicosanoids' named entity 'SFA' named entity 'triglyceride' named entity 'resolvins' named entity 'lipid' named entity 'biomarkers' named entity 'Pneumonia Severity Index' named entity 'albumin' named entity 'geriatric' named entity 'ARDS' named entity 'lipid' named entity 'lower airway' named entity 'triglyceride levels' named entity 'lipidome' named entity 'sphingolipid' named entity 'demographic data' named entity 'PCA' named entity 'autosampler' named entity 'lipopolysaccharide' named entity 'pneumonia'

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