About: Severe novel influenza A (H1N1) infection in cancer patients

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About: Severe novel influenza A (H1N1) infection in cancer patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Severe novel influenza A (H1N1) infection in cancer patients
Creator	Kumar, A Abdalla, E Almeida, J Auler, J Borsato, M Da Silva, L Dolhnikoff, M Filho, R Galas, F Hajjar, L Hoff, P Mauad, T Pierrot, L Saldiva, P Trielli, T
Source	PMC
abstract	Background: The natural history and consequences of severe H1N1 influenza infection among cancer patients are not yet fully characterized. We describe eight cases of H1N1 infection in cancer patients admitted to the intensive care unit of a referral cancer center. Patients and methods: Clinical data from all patients admitted with acute respiratory failure due to novel viral H1N1 infection were reviewed. Lung tissue was submitted for viral and bacteriological analyses by real-time RT-PCR, and autopsy was conducted on all patients who died. Results: Eight patients were admitted, with ages ranging from 55 to 65 years old. There were five patients with solid organ tumors (62.5%) and three with hematological malignancies (37.5%). Five patients required mechanical ventilation and all died. Four patients had bacterial bronchopneumonia. All deaths occurred due to multiple organ failure. A milder form of lung disease was present in the three cases who survived. Lung tissue analysis was performed in all patients and showed diffuse alveolar damage in most patients. Other lung findings were necrotizing bronchiolitis or extensive hemorrhage. Conclusions: H1N1 viral infection in patients with cancer can cause severe illness, resulting in acute respiratory distress syndrome and death. More data are needed to identify predictors of unfavorable evolution in these patients.
has issue date	2010-05-28(xsd:dateTime)
bibo:doi	10.1093/annonc/mdq254
bibo:pmid	20511340
has license	cc-by-nc
sha1sum (hex)	2aa0a28e4246f367ffe104837e755b28d2021f45
schema:url	https://doi.org/10.1093/annonc/mdq254
resource representing a document's title	Severe novel influenza A (H1N1) infection in cancer patients
has PubMed Central identifier	PMC2990816
has PubMed identifier	20511340
schema:publication	Ann Oncol
resource representing a document's body	covid:2aa0a28e4246f367ffe104837e755b28d2021f45#body_text
is schema:about of	named entity 'INFECTION' named entity 'CONSEQUENCES' named entity 'PATIENTS' named entity 'NATURAL HISTORY' named entity 'DESCRIBE' named entity 'FULLY' named entity 'INTENSIVE CARE UNIT' named entity 'CASES' named entity 'BACKGROUND' named entity 'intensive care unit' named entity 'severe' named entity 'SEVERE' covid:arg/2aa0a28e4246f367ffe104837e755b28d2021f45 named entity 'H1N1 INFLUENZA' named entity 'NOVEL' named entity 'INFLUENZA A' named entity 'CANCER CENTER' named entity 'ADMITTED TO' named entity 'PATIENTS' named entity 'INFECTION' named entity 'SEVERE' named entity 'CHARACTERIZED' named entity 'REFERRAL' named entity 'CANCER' named entity 'INFLUENZA INFECTION' named entity 'H1N1' named entity 'CANCER' named entity 'cases' named entity 'cancer' named entity 'referral' named entity 'cancer center' named entity 'H1N1 influenza' named entity 'influenza' named entity 'autopsies' named entity 'comorbidities' named entity 'S. pneumoniae' named entity 'intubation' named entity '2009 pandemic' named entity 'signs and symptoms' named entity 'hypoxemia' named entity 'functional impairment' named entity 'Centers for Disease Control and Prevention' named entity 'United States' named entity 'Sao Paulo' named entity 'nursing care' named entity 'morbidity' named entity 'PEEP' named entity 'diarrhea' named entity 'Physiology' named entity 'multiple organ failure' named entity 'clinical presentation' named entity 'hematological' named entity 'infection' named entity 'urinary tract infection' named entity 'pulmonary thromboembolism' named entity 'esophagus' named entity 'respiratory disease' named entity 'ciprofloxacin' named entity 'ARDS' named entity 'Network protocol' named entity 'ICU' named entity 'hyaline' named entity 'computerized tomography' named entity 'ICU' named entity 'H1N1' named entity 'H1N1 infection' named entity 'respiratory failure'

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