About: Critical role of phospholipase A(2) group IID in age-related susceptibility to severe acute respiratory syndrome

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About: Critical role of phospholipase A(2) group IID in age-related susceptibility to severe acute respiratory syndrome–CoV infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Critical role of phospholipase A(2) group IID in age-related susceptibility to severe acute respiratory syndrome–CoV infection
Creator	Perlman, Stanley Hua, Xiaoyang Vijay, Rahul Miki, Yoshimi Murakami, Makoto Yamamoto, Kei Gelb, Michael Meyerholz, David
topic	covid:2a584d39eb8b164d066dbc8e7496c9a9ff39bc30#this
Source	Medline; PMC
abstract	Oxidative stress and chronic low-grade inflammation in the lungs are associated with aging and may contribute to age-related immune dysfunction. To maintain lung homeostasis, chronic inflammation is countered by enhanced expression of proresolving/antiinflammatory factors. Here, we show that age-dependent increases of one such factor in the lungs, a phospholipase A(2) (PLA(2)) group IID (PLA(2)G2D) with antiinflammatory properties, contributed to worse outcomes in mice infected with severe acute respiratory syndrome-coronavirus (SARS-CoV). Strikingly, infection of mice lacking PLA(2)G2D expression (Pla2g2d(−/−) mice) converted a uniformly lethal infection to a nonlethal one (>80% survival), subsequent to development of enhanced respiratory DC migration to the draining lymph nodes, augmented antivirus T cell responses, and diminished lung damage. We also observed similar effects in influenza A virus–infected middle-aged Pla2g2d(−/−) mice. Furthermore, oxidative stress, probably via lipid peroxidation, was found to induce PLA(2)G2D expression in mice and in human monocyte–derived macrophages. Thus, our results suggest that directed inhibition of a single inducible phospholipase, PLA(2)G2D, in the lungs of older patients with severe respiratory infections is potentially an attractive therapeutic intervention to restore immune function.
has issue date	2015-10-19(xsd:dateTime)
bibo:doi	10.1084/jem.20150632
bibo:pmid	26392224
has license	cc-by-nc-sa
sha1sum (hex)	2a584d39eb8b164d066dbc8e7496c9a9ff39bc30
schema:url	https://doi.org/10.1084/jem.20150632
resource representing a document's title	Critical role of phospholipase A(2) group IID in age-related susceptibility to severe acute respiratory syndrome–CoV infection
has PubMed Central identifier	PMC4612096
has PubMed identifier	26392224
schema:publication	J Exp Med
resource representing a document's body	covid:2a584d39eb8b164d066dbc8e7496c9a9ff39bc30#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/2a584d39eb8b164d066dbc8e7496c9a9ff39bc30
is schema:about of	named entity 'RELATED' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'PHOSPHOLIPASE A 2' named entity 'MIDDLE' named entity 'PROBABLY' named entity 'CORONAVIRUS' named entity 'DERIVED' named entity 'SUBSEQUENT' named entity 'MACROPHAGES' named entity 'SUGGEST' named entity 'SIMILAR' named entity 'RESULTS' named entity 'INDUCE' named entity 'INCREASES' named entity 'LUNG' named entity 'THE LUNGS' named entity 'LYMPH NODES' named entity 'MIGRATION' named entity 'INFLAMMATION' named entity 'PROPERTIES' named entity 'DIMINISHED' named entity 'LACKING' named entity 'INFECTION' named entity 'GRADE' named entity 'HUMAN MONOCYTE' named entity '80%' named entity 'PLA' named entity 'RESPIRATORY' named entity 'Thus' named entity 'lethal' named entity 'PLA' named entity 'PLA' named entity 'inducible' named entity 'lungs' named entity 'middle-aged' named entity 'development' named entity 'expression' named entity '2 group' named entity 'INFECTION' named entity 'CRITICAL' named entity 'HOMEOSTASIS' named entity 'EXPRESSION' named entity 'LIPID PEROXIDATION' named entity 'RESPONSES' covid:arg/2a584d39eb8b164d066dbc8e7496c9a9ff39bc30 named entity 'OXIDATIVE STRESS' named entity 'CHRONIC INFLAMMATION' named entity 'FOUND' named entity 'MICE' named entity 'IID' named entity 'SUSCEPTIBILITY' named entity 'HERE' named entity 'OUR' named entity 'SURVIVAL' named entity 'AGED' named entity 'WORSE' named entity 'DAMAGE' named entity 'IID' named entity 'DEVELOPMENT' named entity 'AGING' named entity 'IMMUNE FUNCTION' named entity 'DEPENDENT' named entity 'SEVERE' named entity 'INFLUENZA A VIRUS' named entity 'TO MAINTAIN' named entity 'ENHANCED' named entity 'ASSOCIATED WITH' named entity 'LOW' named entity 'GROUP' named entity 'FACTOR' named entity 'ATTRACTIVE' named entity 'OBSERVED'

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