About: New insights into pediatric community‐acquired pneumonia gained from untargeted metabolomics: A preliminary study

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: New insights into pediatric community‐acquired pneumonia gained from untargeted metabolomics: A preliminary study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	New insights into pediatric community‐acquired pneumonia gained from untargeted metabolomics: A preliminary study
Creator	Esposito, Susanna Baraldi, Eugenio Zanconato, Stefania Carraro, Silvia Giordano, Giuseppe Pirillo, Paola Stocchero, Matteo Borrello, Giovanni Dalt, Da Liviana, \|
Source	PMC
abstract	BACKGROUND: Available diagnostics often fail to distinguish viral from bacterial causes of pediatric community‐acquired pneumonia (pCAP). Metabolomics, which aims at characterizing diseases based on their metabolic signatures, has been applied to expand pathophysiological understanding of many diseases. In this exploratory study, we used the untargeted metabolomic analysis to shed new light on the etiology of pCAP. METHODS: Liquid chromatography coupled with mass spectrometry was used to quantify the metabolite content of urine samples collected from children hospitalized for CAP of pneumococcal or viral etiology, ascertained using a conservative algorithm combining microbiological and biochemical data. RESULTS: Fifty‐nine children with CAP were enrolled over 16 months. Pneumococcal and viral cases were distinguished by means of a multivariate model based on 93 metabolites, 20 of which were identified and considered as putative biomarkers. Among these, six metabolites belonged to the adrenal steroid synthesis and degradation pathway. CONCLUSIONS: This preliminary study suggests that viral and pneumococcal pneumonia differently affect the systemic metabolome, with a stronger disruption of the adrenal steroid pathway in pneumococcal pneumonia. This finding may lead to the discovery of novel diagnostic biomarkers and bring us closer to personalized therapy for pCAP.
has issue date	2019-12-10(xsd:dateTime)
bibo:doi	10.1002/ppul.24602
bibo:pmid	31821737
has license	no-cc
sha1sum (hex)	2a4ad1bf5652891d9487cf86429d5254c954e32e
schema:url	https://doi.org/10.1002/ppul.24602
resource representing a document's title	New insights into pediatric community‐acquired pneumonia gained from untargeted metabolomics: A preliminary study
has PubMed Central identifier	PMC7168041
has PubMed identifier	31821737
schema:publication	Pediatr Pulmonol
resource representing a document's body	covid:2a4ad1bf5652891d9487cf86429d5254c954e32e#body_text
is schema:about of	named entity 'study' named entity 'Metabolomics' named entity 'UNDERSTANDING' named entity 'PEDIATRIC' named entity 'PEDIATRIC' named entity 'Background' named entity 'diseases' named entity 'pCAP' named entity 'Metabolomics' named entity 'pediatric' named entity 'pediatric' named entity 'lysosomal' named entity 'metabolomic' named entity 'lower respiratory tract infection' named entity 'induce the expression' named entity 'pleural' named entity 'amino acid' named entity 'CAP' named entity 'bacterial resistance' named entity 'sialyl' named entity 'microbiological' named entity 'antibiotic therapy' named entity 'glycyl' named entity 'gly' named entity 'pneumolysin' named entity 'molecule' named entity 'CAP' named entity 'etiology' named entity 'validation set' named entity 'infection' named entity 'lipid metabolism' named entity 'fever' named entity 'nitric oxide' named entity 'clinical presentation' named entity 'pneumonia' named entity 'endotoxin' named entity 'Community-acquired pneumonia' named entity 'urinary excretion' named entity 'biofluids' named entity 'S. pneumoniae' named entity 'metabolism' named entity 'mitochondrial' named entity 'epidemiology' named entity 'overtreatment' named entity 'plasma levels' named entity 'biomedical research' named entity 'transcriptomic' named entity 'S. pneumoniae' named entity 'pneumonia' named entity 'lung examination' named entity 'pCAP' named entity 'respiratory symptoms' named entity 'CAP' named entity 'Carnitine' named entity 'Metabolomics' named entity 'pneumococcal' named entity 'analytical methods' named entity 'metabolic' named entity 'ng/mL' named entity 'ng/mL' named entity 'CAP' named entity 'acute care' named entity 'etiology' named entity 'viral infection' named entity 'CAP' named entity 'chronic disease' named entity 'S. pneumoniae' named entity 'lung infection' named entity 'metabolomic' named entity 'viruses' named entity 'viruses' named entity 'search for new drugs'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software