About: The Therapeutic Potential of Colchicine in the Complications of COVID19. Could the Immunometabolic Properties of an Old and Cheap Drug Help?

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About: The Therapeutic Potential of Colchicine in the Complications of COVID19. Could the Immunometabolic Properties of an Old and Cheap Drug Help? Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Therapeutic Potential of Colchicine in the Complications of COVID19. Could the Immunometabolic Properties of an Old and Cheap Drug Help?
Creator	Amaral, Adilaine Amaral, Ricardo Gonçalves, Sandro Lopes, Cassio Ribeiro, Sandro
Source	Elsevier; Medline; PMC
abstract	The present study analyzes the importance of the inflammasome that involves the NLRP3 complex in the state of hypercytokinemia observed in patients with COVID-19, significantly increasing IL-1β, IL18, IL-6, and TNF. Unfortunately, improving the immune response can sometimes worsen the outcome of the disease. Studies show that colchicine, among other actions, inhibits the assembly of NLRP3 complex that is responsible for generating the active form of Caspase-1 that will convert Pro-IL-1β and Pro-IL-18 into their active forms. We suggest using colchicine, a class of drugs with low-cost, extensively tested, well-tolerated medicine as a complementary treatment for patients with COVID-19, in early stages of the disease based on knowledge of its immunomodulatory properties.
has issue date	2020-07-21(xsd:dateTime)
bibo:doi	10.1016/j.metop.2020.100045
bibo:pmid	32808940
has license	no-cc
sha1sum (hex)	2a426ec09dd362daa328d1f46f2f3321f8f6f1c4
schema:url	https://doi.org/10.1016/j.metop.2020.100045
resource representing a document's title	The Therapeutic Potential of Colchicine in the Complications of COVID19. Could the Immunometabolic Properties of an Old and Cheap Drug Help?
has PubMed Central identifier	PMC7373059
has PubMed identifier	32808940
schema:publication	Metabol Open
resource representing a document's body	covid:2a426ec09dd362daa328d1f46f2f3321f8f6f1c4#body_text
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