About: Immunogenicity of Pigeon Circovirus Recombinant Capsid Protein in Pigeons

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About: Immunogenicity of Pigeon Circovirus Recombinant Capsid Protein in Pigeons Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immunogenicity of Pigeon Circovirus Recombinant Capsid Protein in Pigeons
Creator	Dziewulska, Daria Koncicki, Andrzej Stenzel, Tomasz Kowalczyk, Joanna Tykałowski, Bartłomiej
Source	PMC
abstract	Pigeon circovirus (PiCV) is the most frequently diagnosed virus in pigeons and is thought to be one of the causative factors of a complex disease called the young pigeon disease syndrome (YPDS). The development of a vaccine against this virus could be a strategy for YPDS control. Since laboratory culture of PiCV is impossible, its recombinant capsid protein (rCP) can be considered as a potential antigen candidate in sub-unit vaccines. The aim of this basic research was to evaluate the immune response of pigeons to PiCV rCP. Sixty six-week-old carrier pigeons were divided into two groups (experimental immunized with PiCV rCP mixed with an adjuvant, and control immunized with an adjuvant only), and immunized twice in a 21-day interval. On the day of immunization and on two, 23, 39, and 46 days post first immunization (dpv), samples of blood, spleen, and bursa of Fabricius were collected from six birds from each group to examine anti-PiCV rCP IgY, anti-PiCV rCP IgY-secreting B cells (SBC), IFN-γ gene expression, and percentage of T CD3(+), CD4(+), CD8(+), and B IgM(+) lymphocytes. The results indicated a correct immune response to PiCV rCP both in humoral and cell-mediated immunity, which was manifested by seroconversion since 23 dpv, by a significantly higher anti-PiCV rCP IgY-SBC number on two and 23 dpv, and significantly higher IFN-γ gene expression since two dpv. There were no significant differences or trends noted between particular T and B lymphocyte subpopulations. To conclude, PiCV rCP may be deemed immunogenic and could be considered as an antigen candidate in sub-unit vaccines against PiCV infections in pigeons.
has issue date	2018-10-31(xsd:dateTime)
bibo:doi	10.3390/v10110596
bibo:pmid	30384424
has license	cc-by
sha1sum (hex)	2a3e6aaf35057f4222ef436b616e9d05106e076e
schema:url	https://doi.org/10.3390/v10110596
resource representing a document's title	Immunogenicity of Pigeon Circovirus Recombinant Capsid Protein in Pigeons
has PubMed Central identifier	PMC6265742
has PubMed identifier	30384424
schema:publication	Viruses
resource representing a document's body	covid:2a3e6aaf35057f4222ef436b616e9d05106e076e#body_text
is schema:about of	named entity 'aim' named entity 'circovirus' named entity 'pigeons' named entity 'expression' named entity 'capsid' named entity 'IFN-γ' named entity 'potential' named entity 'Pigeon' covid:arg/2a3e6aaf35057f4222ef436b616e9d05106e076e named entity 'immunization' named entity 'infections' named entity 'higher' named entity 'control' named entity 'protein' named entity 'gene' named entity 'adjuvant' named entity 'laboratory culture' named entity 'CD8' named entity 'Circovirus' named entity 'immune response' named entity 'IFN-γ' named entity 'humoral' named entity 'CD4 +' named entity 'CD8 +' named entity 'gene expression' named entity 'carrier pigeons' named entity 'seroconversion' named entity 'virus' named entity 'lymphocytes' named entity 'immunogenic' named entity 'Circovirus' named entity 'sodium pyruvate' named entity 'spleen' named entity 'pigeon' named entity 'Antibody' named entity 'FITC' named entity 'PCV2' named entity 'control group' named entity 'centrifuged' named entity 'Poland' named entity 'capsid proteins' named entity 'adjuvant' named entity 'Franklin Lakes' named entity 'chicken anemia virus' named entity 'cell surface receptors' named entity 'Merck' named entity 'memory cells' named entity 'circovirus' named entity 'IBV' named entity 'Type IV' named entity 'University of Warmia and Mazury' named entity '0.01' named entity 'IFN-γ' named entity 'experimental group' named entity 'peripheral blood' named entity 'spleens' named entity 'vaccine' named entity 'antibodies' named entity 'IgM' named entity 'collagenase' named entity 'immunization' named entity 'primary antibody' named entity 'Sigma Aldrich' named entity 'diagnostic tests' named entity 'Capsids' named entity 'bursa of Fabricius' named entity 'IFN-γ' named entity 'pathogens' named entity 'spleen' named entity 'spleen' named entity 'control group' named entity 'pigeon' named entity 'gene expression' named entity 'lymphopenia' named entity 'gene' named entity 'blood samples' named entity 'CD8 +'

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