About: The cell receptor level is reduced during persistent infection with influenza C virus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The cell receptor level is reduced during persistent infection with influenza C virus
Creator	Herrler, G Maassab, H Marschall, M Meier-Ewert, H Zimmer, G
Source	Medline; PMC
abstract	Persistent influenza C virus infection of MDCK cells perpetuates the viral genome in a cell-associated form. Typically, virus production remains at a low level over extended periods, in the absence of lytic effects of replication. In this study, we demonstrate that persistently infected cells are very restricted in permissiveness for superinfection. By reconstitution experiments, using bovine brain gangliosides as artificial receptors, the degree of super-infection was markedly increased. Analysis of cellular receptor expression revealed reduced concentrations of sialoglycoproteins in general and a limited presentation of the major receptor gp40. Cocultures of persistently infected and uninfected cells (the latter carrying normal receptor levels) initiated a transient rise in virus titers. This kind of induction of virus synthesis appeared to be mainly receptor-linked, since a receptor-deprived subline, MDCK II, did not give rise to a similar effect. Susceptibility of MDCK II cocultures could be partly restored by ganglioside treatment. In accordance to related virus systems, these findings on influenza C virus suggest a role of cell receptor concentrations in the regulation of long-term persistence.
has issue date	2014-04-03(xsd:dateTime)
bibo:doi	10.1007/s007050050149
bibo:pmid	9229005
has license	no-cc
sha1sum (hex)	2a176a952f06d4611c89b7c1e21cb1709b5e3bac
schema:url	https://doi.org/10.1007/s007050050149
resource representing a document's title	The cell receptor level is reduced during persistent infection with influenza C virus
has PubMed Central identifier	PMC7087292
has PubMed identifier	9229005
schema:publication	Arch Virol
resource representing a document's body	covid:2a176a952f06d4611c89b7c1e21cb1709b5e3bac#body_text
is schema:about of	named entity 'virus' named entity 'genome' named entity 'production' named entity 'The cell' named entity 'COCULTURES' named entity 'concentrations' named entity 'kind' named entity 'reconstitution' named entity 'restored' named entity 'rise' named entity 'superinfection' named entity 'receptor' named entity 'infected' named entity 'concentrations' named entity 'demonstrate' named entity 'brain' named entity 'expression' named entity 'Analysis' named entity 'MDCK' named entity 'virus' named entity 'superinfection' named entity 'MDCK' named entity 'gp40' named entity 'cell receptor' named entity 'virus' named entity 'Johannesburg' named entity 'paramyxovirus' named entity '7.2' named entity 'MDCK' named entity 'acetylesterase' named entity 'cultured cells' named entity 'hemagglutination' named entity 'allantoic cavity' named entity 'wild-type virus' named entity 'Glycoproteins' named entity 'cell culture' named entity 'MDCK' named entity 'RNA genome' named entity 'cell line' named entity 'PBS' named entity 'long-term' named entity 'CD46' named entity 'PBS' named entity 'virus' named entity 'agglutination' named entity 'host cell' named entity 'antigens' named entity 'horse serum' named entity 'cell types' named entity 'IgG' named entity 'IgG' named entity 'MDCK' named entity 'virus' named entity 'formaldehyde' named entity 'ganglioside' named entity 'measles virus' named entity 'virus' named entity 'staining' named entity 'gp40' named entity 'monoclonal antibody' named entity 'glycoprotein' named entity 'MDCK' named entity 'morphology' named entity 'culture medium' named entity 'virus' named entity 'esterase' named entity 'MDCK' named entity 'erythrocytes' named entity 'wheat germ agglutinin' named entity 'viral proteins' named entity 'lysosomal degradation' named entity 'MDCK' named entity 'virus' named entity 'virus' named entity 'gangliosides' named entity 'superinfection' named entity 'MDCK'

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